Telotristat Dosage
Medically reviewed by Drugs.com. Last updated on May 31, 2024.
Applies to the following strengths: 250 mg
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Carcinoid Tumor
250 mg orally 3 times a day
Comments:
- Patients should take this drug with food.
- If needed, short-acting octreotide should be given at least 30 minutes after administration of this drug.
Use: Treatment of carcinoid syndrome diarrhea in combination with somatostatin analog (SSA) therapy in patients whose diarrhea is inadequately controlled by SSA therapy
Usual Adult Dose for Carcinoid Syndrome
250 mg orally 3 times a day
Comments:
- Patients should take this drug with food.
- If needed, short-acting octreotide should be given at least 30 minutes after administration of this drug.
Use: Treatment of carcinoid syndrome diarrhea in combination with somatostatin analog (SSA) therapy in patients whose diarrhea is inadequately controlled by SSA therapy
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Dose Adjustments
Persistent/severe/worsening abdominal pain occurring during use: Discontinue treatment.
Severe constipation occurring during use: Discontinue treatment.
Precautions
CONTRAINDICATIONS: None.
Safety and efficacy have not been established in pediatric patients.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Administration advice:
- Treatment should be taken with food.
- Patients who miss a dose should take the next dose at the regular time; taking 2 doses at the same time should be avoided.
Monitoring:
- GASTROINTESTINAL: Signs/symptoms of severe constipation
- HEPATIC: Liver function tests, especially in patients with liver dysfunction
- PSYCHIATRIC: Signs/symptoms of depression
Patient advice:
- Patients should be told to immediately report signs/symptoms of new/worsening depression, severe constipation, or worsening abdominal pain.
- Inform patients that this drug may cause fatigue, and they should avoid driving or operating machinery if these side effects occur.
- Advise patients to speak to their healthcare provider if they become pregnant, intend to become pregnant, or are breastfeeding.
Frequently asked questions
More about telotristat
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- Drug class: miscellaneous GI agents
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.