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Telotristat Dosage

Medically reviewed by Drugs.com. Last updated on March 22, 2021.

Applies to the following strengths: 250 mg

Usual Adult Dose for Carcinoid Tumor

250 mg orally 3 times a day

Comments:
-Patients should take this drug with food.
-If needed, short-acting octreotide should be given at least 30 minutes after administration of this drug.

Use: Treatment of carcinoid syndrome diarrhea in combination with somatostatin analog (SSA) therapy in patients whose diarrhea is inadequately controlled by SSA therapy

Usual Adult Dose for Carcinoid Syndrome

250 mg orally 3 times a day

Comments:
-Patients should take this drug with food.
-If needed, short-acting octreotide should be given at least 30 minutes after administration of this drug.

Use: Treatment of carcinoid syndrome diarrhea in combination with somatostatin analog (SSA) therapy in patients whose diarrhea is inadequately controlled by SSA therapy

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

Persistent/severe/worsening abdominal pain occurring during use: Discontinue treatment.

Severe constipation occurring during use: Discontinue treatment.

Precautions

CONTRAINDICATIONS: None.

Safety and efficacy have not been established in pediatric patients.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-Treatment should be taken with food.
-Patients who miss a dose should take the next dose at the regular time; taking 2 doses at the same time should be avoided.

Monitoring:
-GASTROINTESTINAL: Signs/symptoms of severe constipation
-HEPATIC: Liver function tests, especially in patients with liver dysfunction
-PSYCHIATRIC: Signs/symptoms of depression

Patient advice:
-Patients should be told to immediately report signs/symptoms of new/worsening depression, severe constipation, or worsening abdominal pain.
-Inform patients that this drug may cause fatigue, and they should avoid driving or operating machinery if these side effects occur.
-Advise patients to speak to their healthcare provider if they become pregnant, intend to become pregnant, or are breastfeeding.

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.