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Spinosad topical Side Effects

Medically reviewed by Last updated on Jan 29, 2022.

For the Consumer

Applies to spinosad topical: topical application suspension

Side effects requiring immediate medical attention

Along with its needed effects, spinosad topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Side effects not requiring immediate medical attention

Some side effects of spinosad topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Burning, dryness, flaking, itching, pain, redness, rash, swelling, or soreness at the site of application
  • redness of the eye or skin


  • Dryness of the scalp or skin
  • hair loss
  • thinning of the hair

For Healthcare Professionals

Applies to spinosad topical: topical suspension


Common (1% to 10%): Application site erythema, application site irritation

Uncommon (0.1% to 1%): Application site dryness, application site exfoliation[Ref]


Common (1% to 10%): Ocular erythema[Ref]


Uncommon (0.1% to 1%): Alopecia, dry skin[Ref]


1. "Product Information. Natroba (spinosad topical)." ParaPRO LLC, Carmel, IN.

2. Popescu CM, Popescu R "Efficacy and safety of spinosad cream rinse for head lice." Arch Dermatol 148 (2012): 1065-9

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.