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Sotradecol Side Effects

Generic Name: sodium tetradecyl sulfate

Note: This document contains side effect information about sodium tetradecyl sulfate. Some of the dosage forms listed on this page may not apply to the brand name Sotradecol.

For the Consumer

Applies to sodium tetradecyl sulfate: intravenous solution

Along with its needed effects, sodium tetradecyl sulfate (the active ingredient contained in Sotradecol) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking sodium tetradecyl sulfate:

Frequency not known
  • Anxiety
  • burning
  • chest pain
  • cough
  • difficulty breathing
  • difficulty swallowing
  • dizziness or light-headedness
  • fainting
  • fast heartbeat
  • hayfever
  • hives
  • itching
  • nausea
  • noisy breathing
  • pain, redness, or swelling in arm or leg
  • puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
  • raised red swellings on the skin, lips, tongue, or in the throat
  • redness of skin
  • skin rash
  • sudden shortness of breath or troubled breathing
  • tightness in chest
  • unusual tiredness or weakness
  • vomiting
  • wheezing

Some side effects of sodium tetradecyl sulfate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Frequency not known
  • Headache
  • pain, local
  • pain or redness at site of injection
  • pale skin at site of injection
  • peeling or sloughing of skin
  • ulceration at site of injection

For Healthcare Professionals

Applies to sodium tetradecyl sulfate: injectable solution


Local side effects have included pain and urticaria or ulceration at the injection site. A permanent discoloration along the path of the sclerosed vein segment has also been reported.[Ref]


Four cases of anaphylactic shock leading to death have been reported in patients receiving sodium tetradecyl sulfate (the active ingredient contained in Sotradecol) Of these four patients, one had a history of asthma.[Ref]

Hypersensitivity side effects have included hives, asthma, hayfever, and anaphylactic shock.[Ref]


Gastrointestinal side effects have included nausea and vomiting.[Ref]


General side effects have included headache.[Ref]


1. "Product Information. Sotradecol (sodium tetradecyl sulfate)." Bioniche Pharma USA Inc, London, AL.

Some side effects of Sotradecol may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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