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Shingrix Side Effects

Generic Name: zoster vaccine, inactivated

Note: This document contains side effect information about zoster vaccine, inactivated. Some of the dosage forms listed on this page may not apply to the brand name Shingrix.

For the Consumer

Applies to zoster vaccine, inactivated: intramuscular suspension

Along with its needed effects, zoster vaccine, inactivated (the active ingredient contained in Shingrix) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking zoster vaccine, inactivated:

  • Ankle, knee, or great toe joint pain
  • blindness
  • blurred vision
  • decreased vision
  • eye pain
  • fever greater than 39 degree Celsius
  • joint stiffness or swelling
  • lower back or side pain
  • swollen, painful, or tender lymph glands in the neck, armpit, or groin

Some side effects of zoster vaccine, inactivated may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Diarrhea
  • difficulty in moving
  • fever
  • headache
  • muscle aches, cramps, pains, or stiffness
  • nausea
  • pain, redness, and swelling at the injection site
  • shivering
  • stomach pain
  • unusual tiredness or weakness
  • vomiting
Less common
  • Chills
  • dizziness
  • general feeling of discomfort or illness
  • itching at the injection site

For Healthcare Professionals

Applies to zoster vaccine, inactivated: intramuscular powder for injection


Very common (10% or more): Local pain (88.4%), local redness (38.7%)
Common (1% to 10%): Injection site pruritus[Ref]


Very common (10% or more): Fatigue (57%), shivering (35.8%), fever (27.8%)
Common (1% to 10%): Malaise
Uncommon (0.1% to 1%): Death[Ref]

Deaths were reported for 0.8% of patients in the treatment group during the first year after vaccination versus 0.9% of placebo patients. Causes of death were consistent with those generally reported in adult and elderly populations.[Ref]

Nervous system

Very common (10% or more): Headache (50.6%)
Common (1% to 10%): Dizziness[Ref]


Very common (10% or more): Gastrointestinal symptoms (24.3%)
Common (1% to 10%): Nausea[Ref]


Uncommon (0.1% to 1%): Gout (including gouty arthritis)[Ref]


Rare (less than 0.1%): Optic ischemic neuropathy[Ref]


Very rare (less than 0.01%): Lymphadenitis[Ref]


Very common (10% or more): Myalgia (56.9%)
Common (1% to 10%): Chills, arthralgia[Ref]


1. "Product Information. Shingrix (zoster vaccine, inactivated)." GlaxoSmithKline, Research Triangle Park, NC.

Some side effects of Shingrix may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.