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Shingrix Side Effects

Generic name: zoster vaccine, inactivated

Medically reviewed by Last updated on May 21, 2022.

Note: This document contains side effect information about zoster vaccine, inactivated. Some of the dosage forms listed on this page may not apply to the brand name Shingrix.

For the Consumer

Applies to zoster vaccine, inactivated: intramuscular suspension

Side effects requiring immediate medical attention

Along with its needed effects, zoster vaccine, inactivated (the active ingredient contained in Shingrix) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking zoster vaccine, inactivated:


  • Ankle, knee, or great toe joint pain
  • blindness
  • blurred vision
  • decreased vision
  • eye pain
  • fever greater than 39 degree Celsius
  • joint stiffness or swelling
  • lower back or side pain
  • swollen, painful, or tender lymph glands in the neck, armpit, or groin

Incidence not known

  • Hives, welts, or itching
  • inability to move the arms and legs
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • redness of the skin
  • sudden numbness and weakness in the arms and legs

Side effects not requiring immediate medical attention

Some side effects of zoster vaccine, inactivated may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Diarrhea
  • difficulty in moving
  • fever
  • headache
  • muscle aches, cramps, pains, or stiffness
  • nausea
  • pain, redness, and swelling at the injection site
  • shivering
  • stomach pain
  • unusual tiredness or weakness
  • vomiting

Less common

  • Chills
  • dizziness
  • general feeling of discomfort or illness
  • itching at the injection site

For Healthcare Professionals

Applies to zoster vaccine, inactivated: intramuscular powder for injection


Very common (10% or more): Local pain (88.4%), local redness (38.7%)

Common (1% to 10%): Injection site pruritus[Ref]


Very common (10% or more): Fatigue (57%), shivering (35.8%), fever (27.8%)

Common (1% to 10%): Malaise

Uncommon (0.1% to 1%): Death[Ref]

Deaths were reported for 0.8% of patients in the treatment group during the first year after vaccination versus 0.9% of placebo patients. Causes of death were consistent with those generally reported in adult and elderly populations.[Ref]

Nervous system

Very common (10% or more): Headache (50.6%)

Common (1% to 10%): Dizziness[Ref]


Very common (10% or more): Gastrointestinal symptoms (24.3%)

Common (1% to 10%): Nausea[Ref]


Uncommon (0.1% to 1%): Gout (including gouty arthritis)[Ref]


Rare (less than 0.1%): Optic ischemic neuropathy[Ref]


Very rare (less than 0.01%): Lymphadenitis[Ref]


Very common (10% or more): Myalgia (56.9%)

Common (1% to 10%): Chills, arthralgia[Ref]

Frequently asked questions


1. "Product Information. Shingrix (zoster vaccine, inactivated)." GlaxoSmithKline (2017):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.