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Riboflavin ophthalmic Side Effects

For the Consumer

Applies to riboflavin ophthalmic: ophthalmic solution

Along with its needed effects, riboflavin ophthalmic may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking riboflavin ophthalmic:

More common
  • Blindness
  • blurred vision
  • change in color vision
  • decreased vision
  • difficulty seeing at night
  • eye pain, irritation or redness, or inflammation
  • feeling of having something in the eye
  • increased sensitivity of the eyes to sunlight
  • painful irritation of the clear front part of the eye
Less common
  • Drainage from the eyes
  • eye discomfort
  • seeing flashes or sparks of light
  • seeing floating spots before the eyes, or a veil or curtain appearing across part of vision
  • sensitivity of the eyes to light

Some side effects of riboflavin ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Dry eyes
  • headache
Less common
  • Double vision
  • redness, swelling, or itching of the eyelid
  • seeing double
  • watering of the eyes

For Healthcare Professionals

Applies to riboflavin ophthalmic: ophthalmic solution

General

The most commonly reported side effects include corneal opacity, punctate keratitis, corneal striae and corneal epithelium defect.[Ref]

Ocular

Very common (10% or more): Corneal opacity/haze (up to 71%), corneal epithelium defect (up to 28%), eye pain (up to 26%), punctate keratitis (up to 25%), corneal striae (up to 24%), photophobia (up to 19%), blurred vision (up to 17%), foreign body sensation in eyes (up to 15%), dry eye (up to 14%), ocular hyperemia (up to 14%), reduced visual acuity (up to 11%)
Common (1% to 10%): Anterior chamber cell, anterior chamber flare, corneal disorder, asthenopia, corneal edema, diplopia, eye discharge, eye edema, eye pruritus, eyelid edema, glare, halo vision, keratitis, increased lacrimation, Meibomian gland dysfunction, ocular discomfort, visual impairment, vitreous detachment
Frequency not reported: Blepharitis, corneal thinning[Ref]

Nervous system

Common (1% to 10%): Headache[Ref]

Other

Common (1% to 10%): Eye complication associated with device[Ref]

References

1. "Product Information. Photrexa (riboflavin ophthalmic)." Avedro, Inc. , Waltham, MA.

2. "Product Information. Photrexa Viscous (riboflavin ophthalmic)." Avedro, Inc. , Waltham, MA.

Some side effects of riboflavin ophthalmic may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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