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Riboflavin ophthalmic Side Effects

Applies to riboflavin ophthalmic: ophthalmic solution

General

The most commonly reported side effects include corneal opacity, punctate keratitis, corneal striae and corneal epithelium defect.[Ref]

Ocular

Very common (10% or more): Corneal opacity/haze (up to 71%), corneal epithelium defect (up to 28%), eye pain (up to 26%), punctate keratitis (up to 25%), corneal striae (up to 24%), photophobia (up to 19%), blurred vision (up to 17%), foreign body sensation in eyes (up to 15%), dry eye (up to 14%), ocular hyperemia (up to 14%), reduced visual acuity (up to 11%)
Common (1% to 10%): Anterior chamber cell, anterior chamber flare, corneal disorder, asthenopia, corneal edema, diplopia, eye discharge, eye edema, eye pruritus, eyelid edema, glare, halo vision, keratitis, increased lacrimation, Meibomian gland dysfunction, ocular discomfort, visual impairment, vitreous detachment
Frequency not reported: Blepharitis, corneal thinning[Ref]

Nervous system

Common (1% to 10%): Headache[Ref]

Other

Common (1% to 10%): Eye complication associated with device[Ref]

References

1. "Product Information. Photrexa (riboflavin ophthalmic)." Avedro, Inc. , Waltham, MA.

2. "Product Information. Photrexa Viscous (riboflavin ophthalmic)." Avedro, Inc. , Waltham, MA.

It is possible that some side effects of riboflavin ophthalmic may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

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