Riboflavin Ophthalmic Dosage

Medically reviewed by Drugs.com. Last updated on Mar 13, 2025.

Usual Adult Dose for Corneal Refractive Surgery

• After epithelial debridement: Apply 1 drop of the viscous solution to the affected eye every 2 minutes for 30 minutes, then, using a slit lamp, examine the eye for a yellow flare in the anterior chamber
• If the yellow flare is not present: Apply 1 drop of viscous solution to the affected eye every 2 minutes for an additional 2 to 3 drops and check for a yellow flare; repeat as necessary
• If the yellow flare is present AND the corneal thickness is less than 400 microns on ultrasound pachymetry: Apply 2 drops of the solution into the affected eye every 5 to 10 seconds until corneal thickness is at least 400 microns
• During irradiation: Apply 1 drop of viscous solution into the affected eye every 2 minutes for the duration of irradiation (e.g., 30 minutes)

Comments:

• This drug should be used at an irradiation level of 3 mW/cm2 at a wavelength of 365 nm.
• The KXL System manufacturer product information should be referred to for patient positioning.

Uses:

• Treatment of progressive keratoconus
• Treatment of corneal ectasia after refractive surgery

Usual Pediatric Dose for Corneal Refractive Surgery

14 years and older:

• After epithelial debridement: Apply 1 drop of the viscous solution to the affected eye every 2 minutes for 30 minutes, then, using a slit lamp, examine the eye for a yellow flare in the anterior chamber
• If the yellow flare is not present: Apply 1 drop of viscous solution to the affected eye every 2 minutes for an additional 2 to 3 drops and check for a yellow flare; repeat as necessary
• If the yellow flare is present AND the corneal thickness is less than 400 microns on ultrasound pachymetry: Apply 2 drops of the solution into the affected eye every 5 to 10 seconds until corneal thickness is at least 400 microns
• During irradiation: Apply 1 drop of viscous solution into the affected eye every 2 minutes for the duration of irradiation (e.g., 30 minutes)

Comments:

• This drug should be used at an irradiation level of 3 mW/cm2 at a wavelength of 365 nm.
• The KXL System manufacturer product information should be referred to for patient positioning.

Uses:

• Treatment of progressive keratoconus
• Treatment of corneal ectasia after refractive surgery

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Safety and efficacy have not been established in patients younger than 14 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

• See manufacturer product information.

Storage requirements:

• See manufacturer product information.

General:

• This drug should only be used with the KXL System.
• Studies have not been performed in patients 65 years and older.

Monitoring:

• Resolution of epithelial defects

Patient advice:

• Patients should be instructed to avoid rubbing the affected eye for up to 5 days.
• Patients should contact their healthcare provider immediately if severe pain and/or sudden visual changes occur; patients should also contact their healthcare provider if the bandage contact lens falls out/becomes dislodged.
• Patients should be cautioned that light sensitivity, discomfort, and/or the sensation of a foreign body may occur after the procedure. The use of sunglasses may decrease light sensitivity.

See also:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer