Riboflavin Ophthalmic Dosage

Medically reviewed by Drugs.com. Last updated on Mar 13, 2025.

Applies to the following strengths: 0.146%

Usual Adult Dose for Corneal Refractive Surgery

After epithelial debridement: Apply 1 drop of the viscous solution to the affected eye every 2 minutes for 30 minutes, then, using a slit lamp, examine the eye for a yellow flare in the anterior chamber
If the yellow flare is not present: Apply 1 drop of viscous solution to the affected eye every 2 minutes for an additional 2 to 3 drops and check for a yellow flare; repeat as necessary
If the yellow flare is present AND the corneal thickness is less than 400 microns on ultrasound pachymetry: Apply 2 drops of the solution into the affected eye every 5 to 10 seconds until corneal thickness is at least 400 microns
During irradiation: Apply 1 drop of viscous solution into the affected eye every 2 minutes for the duration of irradiation (e.g., 30 minutes)

Comments:

This drug should be used at an irradiation level of 3 mW/cm2 at a wavelength of 365 nm.
The KXL System manufacturer product information should be referred to for patient positioning.

Uses:

14 years and older:

After epithelial debridement: Apply 1 drop of the viscous solution to the affected eye every 2 minutes for 30 minutes, then, using a slit lamp, examine the eye for a yellow flare in the anterior chamber
If the yellow flare is not present: Apply 1 drop of viscous solution to the affected eye every 2 minutes for an additional 2 to 3 drops and check for a yellow flare; repeat as necessary
If the yellow flare is present AND the corneal thickness is less than 400 microns on ultrasound pachymetry: Apply 2 drops of the solution into the affected eye every 5 to 10 seconds until corneal thickness is at least 400 microns
During irradiation: Apply 1 drop of viscous solution into the affected eye every 2 minutes for the duration of irradiation (e.g., 30 minutes)

Comments:

This drug should be used at an irradiation level of 3 mW/cm2 at a wavelength of 365 nm.
The KXL System manufacturer product information should be referred to for patient positioning.

Uses:

Data not available

Data not available

Safety and efficacy have not been established in patients younger than 14 years.

Consult WARNINGS section for additional precautions.

Data not available

Administration advice:

Storage requirements:

General:

Monitoring:

Patient advice:

Patients should be instructed to avoid rubbing the affected eye for up to 5 days.
Patients should contact their healthcare provider immediately if severe pain and/or sudden visual changes occur; patients should also contact their healthcare provider if the bandage contact lens falls out/becomes dislodged.
Patients should be cautioned that light sensitivity, discomfort, and/or the sensation of a foreign body may occur after the procedure. The use of sunglasses may decrease light sensitivity.