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Retapamulin topical Side Effects

For the Consumer

Applies to retapamulin topical: topical application ointment

As well as its needed effects, retapamulin topical may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking retapamulin topical, check with your doctor immediately:

Less common:
  • Burning, itching, redness, skin rash, swelling, or soreness at site
  • skin rash, encrusted, scaly, and oozing
  • Blistering, burning, crusting, dryness, flaking of skin
  • flushing, redness of skin
  • itching, scaling, severe redness, soreness, swelling of skin
  • pain at site of application
  • unusually warm skin

Minor Side Effects

Some retapamulin topical side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common:
  • Diarrhea
  • fever
  • headache
  • muscle aches
  • nausea
  • sore throat
  • stuffy or runny nose
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to retapamulin topical: topical ointment


Common (1% to 10%): Pruritus, eczema
Uncommon (0.1% to 1%): Erythema, contact dermatitis, impetigo, excoriation[Ref]


Common (1% to 10%): Application site irritation, application site pruritus, application site pain
Uncommon (0.1% to 1%): Application site erythema
Postmarketing reports: Application site burning sensation[Ref]


Postmarketing reports: Hypersensitivity events including angioedema[Ref]


Common (1% to 10%): Pyrexia
Uncommon (0.1% to 1%): Increased creatinine phosphokinase[Ref]


Common (1% to 10%): Diarrhea, nausea
Uncommon (0.1% to 1%): Abdominal discomfort[Ref]


Common (1% to 10%): Nasopharyngitis[Ref]

Nervous system

Common (1% to 10%): Headache[Ref]


1. "Product Information. Altabax (retapamulin topical)." GlaxoSmithKline, Research Triangle Park, NC.

It is possible that some side effects of retapamulin topical may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.