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Ozenoxacin topical

Generic name: ozenoxacin topical [ oz-en-OX-a-sin-TOP-i-kal ]
Brand name: Xepi
Dosage form: topical cream (1%)
Drug class: Topical antibiotics

Medically reviewed by on Oct 12, 2022. Written by Cerner Multum.

What is ozenoxacin topical?

Ozenoxacin topical is an antibiotic medicine used to treat a skin infection called impetigo.

ozenoxacin topical is for use in adults and children who are at least 2 months old.

Ozenoxacin topical may also be used for purposes not listed in this medication guide.

Ozenoxacin topical side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Ozenoxacin topical may cause serious side effects. Call your doctor at once if you have:

  • any signs of a new skin infection (redness, warmth, swelling, oozing).

Common side effects of ozenoxacin topical may include:

  • skin redness;

  • itching; or

  • skin dryness, peeling, or flaking.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

Tell your doctor if you are pregnant or breast-feeding.

How should I use ozenoxacin topical?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Do not take by mouth. Topical medicine is for use only on the skin.

Apply a thin layer of ozenoxacin topical to the affected skin.

Wash your hands after applying ozenoxacin topical, unless you are treating the skin on your hands.

You may cover the treated skin with a clean bandage or gauze dressing.

Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication.

Call your doctor if your symptoms do not improve after 3 days.

Store at room temperature away from moisture and heat.

Ozenoxacin topical dosing information

Usual Adult Dose for Impetigo:

Apply a thin layer topically to the affected area twice a day for 5 days

Comments: The affected area may be up to 100 cm2.

Use: For the topical treatment of impetigo due to Staphylococcus aureus or Streptococcus pyogenes

Usual Pediatric Dose for Impetigo:

2 months or older: Apply a thin layer topically to the affected area twice a day for 5 days

-The affected area may be 2% of the total body surface area and not exceeding 100 cm2 in patients less than 12 years of age.
-The affected area may be up to 100 cm2 in patients 12 years or older.

Use: For the topical treatment of impetigo due to Staphylococcus aureus or Streptococcus pyogenes

What happens if I miss a dose?

Apply the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not apply two doses at one time.

What happens if I overdose?

An overdose of ozenoxacin topical is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.

What should I avoid while using ozenoxacin topical?

Avoid getting ozenoxacin topical in your eyes, nose, mouth, or vagina.

What other drugs will affect ozenoxacin topical?

Medicine used on the skin is not likely to be affected by other drugs you use. But many drugs can interact with each other. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

Frequently asked questions

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.