Resectisol Side Effects

Generic name: mannitol

Medically reviewed by Drugs.com. Last updated on Jul 30, 2024.

Note: This document provides detailed information about Resectisol Side Effects associated with mannitol. Some dosage forms listed on this page may not apply specifically to the brand name Resectisol.

Applies to mannitol: inhalation capsule.

Other dosage forms:

• intravenous solution

Important warnings This medicine can cause some serious health issues

Inhalation route (powder)

Mannitol (Aridol (TM)) acts as a bronchoconstrictor and may cause severe bronchospasm.

Mannitol bronchial challenge testing is for diagnostic purposes only and should be conducted only by trained professionals under a physician familiar with the test and management of acute bronchospasm (ie, testing area equipped with appropriate medications and equipment).

Immediately administer a short-acting inhaled beta-agonist in the event of severe bronchospasm.

Do not perform bronchial challenge testing with mannitol in a patient with asthma or very low baseline pulmonary function tests (eg, FEV1 less than 1 to 1.5 L or less than 70% of the predicted values).

Serious side effects of Resectisol

Along with its needed effects, mannitol (the active ingredient contained in Resectisol) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking mannitol:

More common side effects

• cough
• coughing or spitting up blood
• sore throat

Less common side effects

• chest discomfort or tightness
• dry heaves
• fever
• runny nose
• trouble breathing
• vomiting

Incidence not known

• gagging

Other side effects of Resectisol

Some side effects of mannitol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• headache

Less common side effects

• difficulty in moving
• dizziness
• muscle pain or stiffness
• nausea
• pain in the joints

For healthcare professionals

Applies to mannitol: compounding powder, inhalation capsule, inhalation kit, intravenous solution, irrigation solution.

Cardiovascular adverse events

Cardiovascular side effects have included hypotension and tachycardia. Venous thrombosis or phlebitis extending from the injection site and hypervolemia have occurred rarely and are generally associated with the solution or technique used in administration.^[Ref]

Respiratory

Respiratory side effects have included pulmonary congestion and rhinitis. Respiratory side effects associated with mannitol (the active ingredient contained in Resectisol) inhalation have included cough, gagging, wheeze, and decreased forced expiratory volume.^[Ref]

Metabolic

Metabolic side effects have included fluid and electrolyte imbalance, acidosis, and electrolyte loss.^[Ref]

Nervous system

Nervous system side effects have included headache, convulsions, and dizziness.^[Ref]

Hematologic

Hematologic side effects have included thrombophlebitis.^[Ref]

Other

Other side effects have included dryness of mouth, thirst, edema, arm pain, chills, dehydration, fever, mannitol (the active ingredient contained in Resectisol) intoxication, and angina-like pain.^[Ref]

Eight cases of mannitol IV overdose in patients with preexisting renal failure were reviewed. Symptoms presented in the reviewed cases were CNS involvement out of proportion to uremia, severe hyponatremia, large osmolality gap, and fluid overload. Six patients were treated with hemodialysis, one patient with peritoneal dialysis, and one patient died before initiation of treatment. All patients received large doses over 1 to 3 days with a mean dose of 310 +/- 182.8 g. CNS involvement consisted of CNS depression, confusion, lethargy, stupor, and coma. Two patients recovered cerebral function and continued on lifetime dialysis, 3 patients recovered renal and cerebral function, and 1 patient recovered renal function but had severe cerebral dysfunction.^[Ref]

Renal

Renal side effects have included acute renal failure.^[Ref]

Local

Local side effects have included extravasation. This effect is generally attributed to the solution or technique used in administration.^[Ref]

Dermatologic

Dermatologic side effects have included urticaria and skin necrosis.^[Ref]

Ocular

Ocular side effects have included blurred vision.^[Ref]

Immunologic

Immunologic side effects have included infection at the injection site and febrile response. These effects are usually attributed to solution or technique used in administration.^[Ref]

Gastrointestinal

Gastrointestinal side effects have included nausea and vomiting.^[Ref]

Genitourinary

Genitourinary side effects have included marked diuresis and urinary retention.^[Ref]

Psychiatric

Psychiatric side effects have rarely included mania (1 case report).^[Ref]

A 75-year-old woman with severe major depression experienced a manic episode 30 minutes after initiation of a 20% mannitol intravenous infusion for the treatment of acute angle closure glaucoma. The patient had been started on nortriptyline 50 mg per day for the treatment of depression ten days earlier. She received oral acetazolamide, topical pilocarpine, topical timolol, and topical dexamethasone concomitantly for the treatment of glaucoma. The mania resolved within approximately 1 hour following discontinuation of the mannitol infusion, and the patient returned to a severe depressive state. An extensive lab evaluation, toxicology screening, and medical examination failed to show additional secondary causes for mania in this patient.^[Ref]

Further information

Resectisol side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer