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Rectocort HC Side Effects

Generic name: hydrocortisone / pramoxine topical

Medically reviewed by Last updated on May 13, 2024.

Note: This document contains side effect information about hydrocortisone / pramoxine topical. Some dosage forms listed on this page may not apply to the brand name Rectocort HC.

Applies to hydrocortisone/pramoxine topical: external cream, external foam, rectal kit.

Serious side effects of Rectocort HC

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

Other side effects of Rectocort HC

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

For Healthcare Professionals

Applies to hydrocortisone/pramoxine topical: rectal cream, rectal foam, rectal kit, rectal lotion, topical cream, topical foam, topical gel, topical lotion, topical ointment.


Frequency not reported: Burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, miliaria[Ref]


Frequency not reported: Reversible suppression of the hypothalamic-pituitary-adrenal axis, manifestations of Cushing's syndrome[Ref]


Frequency not reported: Blurred vision[Ref]


Frequency not reported: Affective disorders (e.g. irritable, euphoric, depressed, labile mood, suicidal thoughts), psychotic reactions (e.g. mania, delusions, hallucinations, aggravation of schizophrenia), behavioral disturbances, irritability, anxiety, sleep disturbances, cognitive dysfunction (including confusion and amnesia)[Ref]


1. (2005) "Product Information. Proctofoam HC (hydrocortisone-pramoxine topical)." Meda Pharmaceuticals

2. Cerner Multum, Inc. "UK Summary of Product Characteristics."

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.