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Pneumococcal 15-valent conjugate vaccine Side Effects

Medically reviewed by Drugs.com. Last updated on Dec 29, 2023.

Applies to pneumococcal 15-valent conjugate vaccine: intramuscular suspension.

Serious side effects

Along with its needed effects, pneumococcal 15-valent conjugate vaccine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking pneumococcal 15-valent conjugate vaccine:

Less common

Other side effects

Some side effects of pneumococcal 15-valent conjugate vaccine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

For Healthcare Professionals

Applies to pneumococcal 15-valent conjugate vaccine: intramuscular suspension.

General

The most commonly reported side effects included localized pain, irritability, elevated body temperature (from at least 38C to less than 39C), and somnolence.[Ref]

Dermatologic

Common (1% to 10%): Urticaria[Ref]

Local

Very common (10% or more): Localized pain (up to 75.8%), localized erythema (up to 21.6%), localized swelling (up to 21.7%), localized induration (up to 14.1%)

Uncommon (0.1% to 1%): Injection site urticaria[Ref]

Metabolic

Very common (10% or more): Decreased appetite (up to 19.4%)[Ref]

Musculoskeletal

Very common (10% or more): Myalgia (up to 28.8%), arthralgia (up to 12.7%)[Ref]

Nervous system

Very common (10% or more): Somnolence (up to 40.7%), headache (up to 26.5%)[Ref]

Other

Very common (10% or more): Elevated body temperature (at least 38C to less than 39C [up to 50.8%]), fatigue (up to 34.3%)

Common (1% to 10%): Elevated body temperature (at least 39C to less than 40C), elevated body temperature (at least 40C)[Ref]

Psychiatric

Very common (10% or more): Irritability (up to 55.1%)

Common (1% to 10%): Extreme distress, unable to do unusual activities[Ref]

References

1. (2021) "Product Information. Vaxneuvance (pneumococcal 15-valent conjugate vaccine)." Merck & Co., Inc

2. (2023) "Product Information. Vaxneuvance (pneumococcal 15-valent conjugate vaccine)." Merck Sharp & Dohme (Australia) Pty Ltd

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.