Pergonal Side Effects

Generic name: menotropins

Medically reviewed by Drugs.com. Last updated on Sep 30, 2024.

Note: This document provides detailed information about Pergonal.

Applies to menotropins: powder for solution Side Effects associated with menotropins. Some dosage forms listed on this page may not apply specifically to the brand name Pergonal.

Applies to menotropins: powder for solution.

Precautions

It is very important that your doctor check your progress at regular visits to make sure that the medicine is working properly and to check for unwanted effects. Blood and urine tests, and ultrasound examinations are needed to check for any unwanted effects caused by this medicine.

Call your doctor right away if you think you have become pregnant while you are using this medicine. You may have a higher risk of an ectopic pregnancy or miscarriage if you get pregnant while undergoing IVF procedures. An ectopic pregnancy can be a serious and life-threatening condition. It can also cause problems that may make it harder for you to become pregnant in the future.

If your doctor has asked you to record your basal body temperatures (BBTs) daily, make sure that you know how to do this. Carefully follow your doctor's instructions.

This medicine may increase your risk of having a problem with the ovaries called ovarian hyperstimulation syndrome (OHSS). OHSS is a serious problem that can be life-threatening. Call your doctor right away if you have severe pain in the lower stomach area, nausea, vomiting, weight gain, diarrhea, decreased urine output, or trouble breathing.

This medicine may increase your risk of having a blood clot, heart attack, or stroke. This is more likely in people who already have heart disease. Contact your doctor right away if you have chest pain, tightness in the chest, a fast or irregular heartbeat, unusual flushing or warmth of the skin, increased coughing, trouble with breathing, a sudden difficulty with breathing at night, or abnormal swelling in your ankles or legs. These could be symptoms of serious heart problems or blood clots.

This medicine may cause more than one egg to be released from your ovary at the same time. This means you may become pregnant with more than one baby. Talk with your doctor about this possibility before you start using this medicine.

This medicine may increase your risk of having ovarian cancer if you received it more than one time to get pregnant. Talk to your doctor about this risk.

Serious side effects of Pergonal

Along with its needed effects, menotropins (the active ingredient contained in Pergonal) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking menotropins:

For females only

Other side effects of Pergonal

Some side effects of menotropins may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For females only

After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, Check with your doctor immediately if you notice the following side effects:

For females only

• abdominal or stomach pain (severe)
• bloating (moderate to severe)
• decreased amount of urine
• feeling of indigestion
• nausea, vomiting, or diarrhea (continuing or severe)
• pelvic pain (severe)
• shortness of breath
• weight gain (rapid)

For healthcare professionals

Applies to menotropins: injectable powder for injection, intramuscular powder for injection, subcutaneous powder for injection.

General adverse events

The most frequently reported adverse drug reactions reported are abdominal pain, headache, injection site reactions, and injection site pain^[Ref]

Genitourinary

• Very common (10% or more): Multiple pregnancy (35.3%)
• Common (1% to 10%): Ovarian Hyperstimulation Syndrome (OHSS), abnormal ovarian enlargement, ovarian disease, vaginal hemorrhage, pelvic pain, breast pain, ectopic pregnancy
• Postmarketing reports: Ovarian cyst, breast complaints (including breast tenderness, breast discomfort and breast swelling)
• Frequency not reported: Ovarian torsion^[Ref]

Gastrointestinal

• Common (1% to 10%): Abdominal pain, abdominal cramps, enlarged abdomen, nausea and vomiting, diarrhea, fullness and pain
• Postmarketing reports: Nausea, abdominal pain lower, abdominal distension, abdominal discomfort
• Frequency not reported: Diarrhea^[Ref]

Immunologic

• Common (1% to 10%): Infection
• Frequency not reported: Formation of antibodies^[Ref]

Local

• Common (1% to 10%): Injection site pain/reaction, injection site inflammation, injection site edema^[Ref]

Nervous system

• Common (1% to 10%): Headache
• Postmarketing reports: Dizziness^[Ref]

Respiratory

• Common (1% to 10%): Dyspnea^[Ref]

Cardiovascular

• Uncommon (0.1% to 1%): Thrombophlebitis, deep vein thrombosis
• Postmarketing reports: Hot flush^[Ref]

Hypersensitivity

• Frequency not reported: Hypersensitivity^[Ref]

Dermatologic

• Postmarketing reports: Acne, rash, pruritus^[Ref]

Musculoskeletal

• Postmarketing reports: Arthralgia^[Ref]

Ocular

• Postmarketing reports: Visual disorders (blurred vision, vision impairment including amaurosis, diplopia, mydriasis, photopsia, scotoma and vitreous floaters)^[Ref]

Other

• Postmarketing reports: Fatigue, pyrexia^[Ref]

See also:

Further information

Pergonal side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer