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Numbrino Side Effects

Generic name: cocaine nasal

Medically reviewed by Last updated on Sep 26, 2022.

Note: This document contains side effect information about cocaine nasal. Some dosage forms listed on this page may not apply to the brand name Numbrino.

Applies to cocaine nasal: nasal solution.


Nasal route (Spray)

Warning: Abuse and DependenceCNS stimulants, including cocaine hydrochloride, have a high potential for abuse and dependence.

Serious side effects of Numbrino

Along with its needed effects, cocaine nasal (the active ingredient contained in Numbrino) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking cocaine nasal:

More common

Less common

  • Chest pain or discomfort
  • fainting
  • fast, pounding, or irregular heartbeat or pulse
  • lightheadedness
  • unusual tiredness

Incidence not known

Other side effects of Numbrino

Some side effects of cocaine nasal may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

For Healthcare Professionals

Applies to cocaine nasal: nasal solution.


The most common adverse reactions were headache and epistaxis.[Ref]

Nervous system

Common (1% to 10%): Headache[Ref]


Common (1% to 10%): Anxiety

Frequency not reported: Rapid eye movement sleep decreased, total sleep decreased[Ref]


Frequency not reported: Cardiac activity increased, vasoconstriction[Ref]


Frequency not reported: Anorexic effect[Ref]


Frequency not reported: Body temperature increased[Ref]


Common (1% to 10%): Epistaxis[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Cocaine Hydrochloride Nasal (cocaine nasal)." Genus Lifesciences Inc. (2018):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.