MenQuadfi Side Effects

Generic name: meningococcal conjugate vaccine

Medically reviewed by Drugs.com. Last updated on Jun 7, 2025.

Note: This document provides detailed information about MenQuadfi Side Effects associated with meningococcal conjugate vaccine. Some dosage forms listed on this page may not apply specifically to the brand name MenQuadfi.

Applies to meningococcal conjugate vaccine: intramuscular suspension.

Other dosage forms:

• intramuscular solution

Precautions

It is very important that your doctor check you or your child at regular visits to make sure this vaccine is working properly and to check for unwanted effects.

Contact your doctor immediately if you or your child have sudden weakness or are not able to move your arms or legs. This could be a sign of a serious condition called Guillain-Barré syndrome (GBS).

Check with your doctor right away if you have a cough, difficulty with swallowing, dizziness, fast heartbeat, hives, itching, puffiness or swelling of the eyelids or around the eyes, face, lips or tongue, shortness of breath, skin rash, tightness in the chest, unusual tiredness or weakness, or wheezing. These could be symptoms of an allergic reaction to the vaccine.

Syncope (fainting) may occur after receiving this vaccine. Your doctor may want you or your child to be observed for 15 minutes after you get the injection to prevent and manage fainting.

This vaccine may cause apnea (breathing stops for short periods) in some premature infants. Discuss this with your child's doctor if you are concerned.

It is important that your doctor should know about all other vaccines you or your child have recently received, including a flu shot.

Make sure your doctor knows if you are using medicines that weaken your immune system such as cancer medicines, radiation treatment, or steroids.

It is important to tell your doctor if you become pregnant. Your doctor may want you to join a pregnancy registry for patients receiving this vaccine.

This vaccine will not prevent diphtheria, and will not treat symptoms of meningococcal infection if you already have the disease.

Serious side effects of MenQuadfi

Along with its needed effects, meningococcal conjugate vaccine (the active ingredient contained in MenQuadfi) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking meningococcal conjugate vaccine:

More common side effects

• chills
• fever
• general feeling of discomfort or illness
• unusual tiredness or weakness

Incidence not known

• back pain, sudden and severe
• blurred vision
• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• confusion
• cough
• difficulty with swallowing
• dizziness
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• fainting
• fast heartbeat
• flushing or redness of the skin
• hives or welts
• inability to move the arms and legs
• itching
• muscle weakness, sudden and progressing
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• seizures
• shortness of breath
• skin rash
• sudden numbness and weakness in the arms and legs
• sweating
• tightness in the chest
• unusually warm skin
• wheezing

Other side effects of MenQuadfi

Some side effects of meningococcal conjugate vaccine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• crying
• diarrhea
• difficulty with moving
• drowsiness
• irritability
• loss of appetite
• muscle pain or stiffness
• pain in the joints
• pain, redness, swelling, or tenderness at the injection site
• vomiting

For healthcare professionals

Applies to meningococcal conjugate vaccine: intramuscular powder for injection, intramuscular solution.

General adverse events

The most common adverse events were injection site pain, irritability, diarrhea, headache, and fatigue.^[Ref]

Local

• Very common (10% or more): Injection site pain (48.1%), injection site redness (16%), injection site induration (11%)
• Common (1% to 10%): Injection site swelling, injection site hematoma
• Uncommon (0.1% to 1%): Injection site pruritus
• Postmarketing reports: Injection site reaction, injection site cellulitis, extensive swelling of the injected limb (frequently associated with erythema, sometimes involving the adjacent joint or swelling of the entire injected limb)^[Ref]

Nervous system

• Very common (10% or more): Headache (41.8%), drowsiness (11.2%)
• Uncommon (0.1% to 1%): Dizziness, hypoesthesia
• Postmarketing reports: Vasovagal syncope, paresthesia, Guillain-Barre syndrome, vertigo, tonic convulsion, febrile convulsion, vertigo, vestibular disorder, syncope, facial paresis, balance disorder^[Ref]

Gastrointestinal

• Very common (10% or more): Diarrhea (14%), nausea
• Common (1% to 10%): Vomiting, gastrointestinal symptoms^[Ref]

Other

• Very common (10% or more): Fatigue (32.3%), malaise (22.3%), fever
• Common (1% to 10%): Chills, crying
• Postmarketing reports: Asthenia, impaired hearing, ear pain, fall, head injury, body temperature increased^[Ref]

Dermatologic

• Common (1% to 10%): Rash
• Uncommon (0.1% to 1%): Pruritus
• Postmarketing reports: Bullous conditions^[Ref]

Musculoskeletal

• Very common (10% or more): Arthralgia (16%), myalgia
• Uncommon (0.1% to 1%): Pain in extremity
• Postmarketing reports: Bone pain^[Ref]

Psychiatric

• Very common (10% or more): Irritability (12.2%)
• Common (1% to 10%): Insomnia^[Ref]

Metabolic

• Very common (10% or more): Appetite lost
• Common (1% to 10%): Anorexia, eating disorder^[Ref]

Respiratory

• Uncommon (0.1% to 1%): Nasopharyngitis
• Postmarketing reports: Oropharyngeal pain^[Ref]

Hypersensitivity

• Postmarketing reports: Hypersensitivity (such as rash, urticaria, pruritus, dyspnea, angioedema) including anaphylaxis^[Ref]

Hepatic

• Postmarketing reports: Alanine aminotransferase increased^[Ref]

Ocular

• Postmarketing reports: Eyelid ptosis^[Ref]

Further information

MenQuadfi side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer