Luspatercept Side Effects

Medically reviewed by Drugs.com. Last updated on May 12, 2024.

Applies to luspatercept: parenteral injection for sub-q use.

Side effects include:

Most common (>10%) adverse reactions: fatigue, headache, musculoskeletal pain, arthralgia, dizziness/vertigo, nausea, diarrhea, cough, abdominal pain, dyspnea, COVID-19, peripheral edema, hypertension, hypersensitivity.

For healthcare professionals

Applies to luspatercept: subcutaneous powder for injection.

Hepatic

• Very common (10% or more): Total bilirubin 2 or more times the upper limit of normal (ULN) (64%), alanine aminotransferase 3 or more times ULN (12%), aspartate aminotransferase 3 or more times ULN (11%)
• Common (1% to 10%): Alkaline phosphatase 2 or more times ULN, direct bilirubin 2 or more times ULN^[Ref]

Cardiovascular

• Common (1% to 10%): Hypertension, deep vein thrombosis^[Ref]

Nervous system

• Very common (10% or more): Headache (26%), dizziness (11%)
• Common (1% to 10%): Cerebrovascular accident^[Ref]

Musculoskeletal

• Very common (10% or more): Bone pain (20%), arthralgia (19%)^[Ref]

Gastrointestinal

• Very common (10% or more): Abdominal pain (14%), diarrhea (12%)
• Common (1% to 10%): Nausea^[Ref]

Metabolic

• Common (1% to 10%): Hyperuricemia^[Ref]

Respiratory

• Very common (10% or more): Cough (14%)^[Ref]

Immunologic

• Common (1% to 10%): Influenza, viral upper respiratory infection^[Ref]

Other

• Very common (10% or more): Fatigue (14%)
• Frequency not reported: Death (due to unconfirmed acute myelogenous leukemia)^[Ref]

Further information

Luspatercept side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer