Luspatercept Side Effects
Medically reviewed by Drugs.com. Last updated on Oct 20, 2024.
Applies to luspatercept: parenteral injection for sub-q use.
Side effects include:
Most common (>10%) adverse reactions: fatigue, headache, musculoskeletal pain, arthralgia, dizziness/vertigo, nausea, diarrhea, cough, abdominal pain, dyspnea, COVID-19, peripheral edema, hypertension, hypersensitivity.
For healthcare professionals
Applies to luspatercept: subcutaneous powder for injection.
Hepatic adverse events
- Very common (10% or more): Total bilirubin 2 or more times the upper limit of normal (ULN) (64%), alanine aminotransferase 3 or more times ULN (12%), aspartate aminotransferase 3 or more times ULN (11%)
- Common (1% to 10%): Alkaline phosphatase 2 or more times ULN, direct bilirubin 2 or more times ULN[Ref]
Cardiovascular
- Common (1% to 10%): Hypertension, deep vein thrombosis[Ref]
Nervous system
- Very common (10% or more): Headache (26%), dizziness (11%)
- Common (1% to 10%): Cerebrovascular accident[Ref]
Musculoskeletal
- Very common (10% or more): Bone pain (20%), arthralgia (19%)[Ref]
Gastrointestinal
- Very common (10% or more): Abdominal pain (14%), diarrhea (12%)
- Common (1% to 10%): Nausea[Ref]
Metabolic
- Common (1% to 10%): Hyperuricemia[Ref]
Respiratory
- Very common (10% or more): Cough (14%)[Ref]
Immunologic
Other
- Very common (10% or more): Fatigue (14%)
- Frequency not reported: Death (due to unconfirmed acute myelogenous leukemia)[Ref]
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References
1. (2019) "Product Information. Reblozyl (luspatercept)." Celgene Corporation
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Further information
Luspatercept side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.