Lonapegsomatropin Side Effects

Medically reviewed by Drugs.com. Last updated on Aug 12, 2024.

Applies to lonapegsomatropin: subcutaneous powder for solution.

Precautions

If you will be taking this medicine for a long time, it is very important that your doctor check you and your child's progress at regular visits. Blood and urine tests may be needed to check for any problems or unwanted effects that may be caused by this medicine.

This medicine may cause serious allergic reactions, including anaphylaxis and angioedema, which are life-threatening and require immediate medical attention. Tell your doctor right away if you or your child have a rash, itching, swelling of the face, tongue, or throat, trouble breathing, or chest pain after receiving this medicine.

Using this medicine may increase your or your child's risk of getting cancer. Talk to your doctor if you have concerns about this risk.

This medicine may affect blood sugar levels. Check with your doctor if you notice a change in the results of your or your child's blood or urine sugar tests or if you have any questions.

Check with your doctor right away if you or your child have decrease in amount of urine, noisy, rattling breathing, swelling of the fingers, hands, feet, or lower legs, or weight gain. These may be symptoms of fluid retention (extra water in the body).

This medicine may cause an increased pressure in the head. Check with your doctor immediately if headache, nausea, vomiting, blurred vision, or any other change in vision occurs during treatment. Your doctor may want you to have your or your child's eyes checked by an ophthalmologist (eye doctor).

Check with your doctor right away if you have darkening of skin, diarrhea, dizziness, fainting, loss of appetite, mental depression, nausea, skin rash, unusual tiredness or weakness, or vomiting. These may be symptoms of an adrenal gland problem (hypoadrenalism).

Pancreatitis (inflammation of the pancreas) has occurred rarely in some patients receiving lonapegsomatropin-tcgd. Tell your doctor right away if you or your child have sudden and severe stomach pain, chills, constipation, nausea, vomiting, fever, or lightheadedness.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of lonapegsomatropin

Along with its needed effects, lonapegsomatropin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking lonapegsomatropin:

Other side effects of lonapegsomatropin

Some side effects of lonapegsomatropin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to lonapegsomatropin: subcutaneous injection.

General adverse events

The most common adverse events were viral infection, pyrexia, cough, and nausea and vomiting.^[Ref]

Immunologic

• Very common (10% or more): Viral infection (15%)^[Ref]

Other

• Very common (10% or more): Pyrexia (15%)
• Frequency not reported: Increased mortality in patients with acute critical illness, sudden death in pediatric patients with Prader-Willi syndrome^[Ref]

Gastrointestinal

• Very common (10% or more): Nausea and vomiting (11%)
• Common (1% to 10%): Diarrhea, abdominal pain
• Frequency not reported: Pancreatitis^[Ref]

Hematologic

• Common (1% to 10%): Hemorrhage^[Ref]

Musculoskeletal

• Common (1% to 10%): Arthralgia and arthritis
• Frequency not reported: Slipped capital femoral epiphysis in pediatric patients, progression of preexisting scoliosis in pediatric patients^[Ref]

Hypersensitivity

• Frequency not reported: Severe hypersensitivity^[Ref]

Respiratory

• Very common (10% or more): Cough (11%)^[Ref]

Nervous system

• Frequency not reported: Intracranial hypertension^[Ref]

Oncologic

• Frequency not reported: Increased risk of neoplasms^[Ref]

Metabolic

• Frequency not reported: Glucose intolerance and diabetes mellitus, fluid retention, elevated phosphate and alkaline phosphatase levels^[Ref]

Endocrine

• Frequency not reported: Hypoadrenalism, hypothyroidism^[Ref]

See also:

Further information

Lonapegsomatropin side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer