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Lonapegsomatropin Dosage

Medically reviewed by Drugs.com. Last updated on Mar 14, 2022.

Applies to the following strengths: tcgd 3 mg; tcgd 3.6 mg; tcgd 4.3 mg; tcgd 5.2 mg; tcgd 6.3 mg; tcgd 7.6 mg; tcgd 9.1 mg; tcgd 11 mg; tcgd 13.3 mg

Usual Pediatric Dose for Pediatric Growth Hormone Deficiency

1 year and older and weighing at least 11.5 kg:
Recommended dose: 0.24 mg/kg subcutaneously once a week

Comments:

  • Individualize dose based on response.
  • Round dose to closest cartridge dose while considering treatment goals and patient response.
  • If no increase in height velocity, particularly during the first year of treatment, assess compliance and evaluate other causes of poor growth such as hypothyroidism, undernutrition, advanced bone age and antibodies to recombinant human growth hormone.
  • Discontinue once epiphyseal fusion has occurred.

Use: Treatment of pediatric patients 1 year and older who weigh at least 11.5 kg and have growth failure due to inadequate secretion of endogenous growth hormone (GH)

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS:

  • Acute critical illness
  • Hypersensitivity to any of the ingredients
  • Children with closed epiphyses
  • Active malignancy
  • Active proliferative or severe non-proliferative diabetic retinopathy
  • Children with Prader-Willi syndrome who are severely obese or have severe respiratory impairment due to risk of sudden death

Safety and efficacy have not been established in patients younger than 1 year; this drug is not recommended for use in these patients.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

  • Rotate administration site to avoid lipoatrophy.

Monitoring:
  • Therapy should be supervised by a physician experienced in the diagnosis and management of pediatric growth failure due to growth hormone deficiency (GHD).
  • To exclude preexisting papilledema, perform fundoscopic examination before initiating treatment and reassess periodically thereafter.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.