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Liposyn III Side Effects

Generic Name: fat emulsion

Note: This document contains side effect information about fat emulsion. Some of the dosage forms listed on this page may not apply to the brand name Liposyn III.

For the Consumer

Applies to fat emulsion: intravenous emulsion

Along with its needed effects, fat emulsion (the active ingredient contained in Liposyn III) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking fat emulsion:

More common
  • Bladder pain
  • bloody or cloudy urine
  • chills
  • difficult, burning, or painful urination
  • fever
  • frequent urge to urinate
  • lower back or side pain
  • sore throat
  • vomiting
Rare Incidence not known
  • Abdominal or stomach pain
  • changes in skin color
  • changes in urination
  • fruit-like breath odor
  • increased thirst
  • rash
  • swelling and redness in the lower leg
  • unusual bleeding or bruising

Some side effects of fat emulsion may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Nausea
  • Redness, swelling, or pain at the injection site
Less common

For Healthcare Professionals

Applies to fat emulsion: intravenous emulsion


Common (1% to 10%): Cholestasis, blood bilirubin increased
Uncommon (0.1% to 1%): Cytolytic hepatitis, cholecystitis, cholelithiasis, liver function test abnormalities, pancreatic enzyme increased
Frequency not reported: Increased gamma-glutamyltransferase, hepatomegaly, jaundice due to central lobular cholestasis, transient increases in liver function tests[Ref]


Common (1% to 10%): Anemia
Uncommon (0.1% to 1%): Leukopenia
Rare (less than 0.1%): Thrombocytopenia in neonates
Frequency not reported: Leukocytosis, hypercoagulability, splenomegaly, thrombocytopenia[Ref]


Common (1% to 10%): Hypertension, mean arterial pressure decreased
Uncommon (0.1% to 1%): Circulatory collapse, hypotension, hot flush
Frequency not reported: Tachycardia, thrombophlebitis, cyanosis, flushing, arrhythmia[Ref]


Frequency not reported: Allergic reaction, hypersensitivity[Ref]


Common (1% to 10%): Sepsis, device related infection
Frequency not reported: Pneumonia, infection, septicemia[Ref]


Common (1% to 10%): Pyrexia
Frequency not reported: Increased blood alkaline phosphatase, increased C-reactive protein, increase in temperature, pain in chest and back, slight pressure over the eyes, overloading syndrome (focal seizures, fever, leukocytosis, hepatomegaly, splenomegaly, and shock), intravenous fat pigment (deposition of brown pigmentation in the reticuloendothelial system), increased blood level of immunosuppressant drug, asthenia, malaise
Postmarketing reports: International normalized ration decreased[Ref]

Nervous system

Frequency not reported: Dysgeusia, headache, dizziness, sleepiness, cerebral edema, convulsion[Ref]


Common (1% to 10%): Muscle spasms
Uncommon (0.1% to 1%): Back pain, chills
Frequency not reported: Bone necrosis


Frequency not reported: Respiratory insufficiency[Ref]


Common (1% to 10%): Nausea, vomiting, flatulence, abdominal pain, dyspepsia, abdominal distension, epigastric discomfort
Frequency not reported: Diarrhea[Ref]


Frequency not reported: Pruritus, rash, sweating[Ref]


Common (1% to 10%): Urinary tract infection[Ref]


Frequency not reported: Irritation at sight of infusion[Ref]


Common (1% to 10%): Hyperglycemia, blood triglycerides increased, hyperproteinemia, hyperlipidemia
Frequency not reported: Hyperlipemia, diabetes mellitus inadequate control, hypoproteinemia[Ref]


1. "Product Information. Intralipid (fat emulsion, intravenous)." Baxter I.V. Systems Division, Round Lake, IL.

2. "Product Information. Smoflipid (fat emulsion, intravenous)." Fresenius Kabi USA, Lake Zurich, IL.

Some side effects of Liposyn III may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

More about Liposyn III (fat emulsion)

Consumer resources

Other brands: SMOFlipid, Clinolipid

Professional resources

Related treatment guides

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.