Fat Emulsion Dosage
Applies to the following strengths: 30%; 10%; 20%; with fish oil 10%; with fish, medium chain, olive, and soy oil 20%
Usual Adult Dose for:
Usual Pediatric Dose for:
Additional dosage information:
Usual Adult Dose for Dietary Supplement
Usual dosage: 1 to 2 g/kg/day, IV
- Initial infusion rate should be 0.1 g/min for the first 15 to 30 minutes.
- May gradually increase rate after 30 minutes if tolerated.
- Maximum rate should not exceed 0.1 g/kg/hour.
- Duration of infusion is from 12 to 24 hours, depending on clinical situation.
- Maximum dose: 2.5 grams/kg/day, also, the daily dose should not exceed a maximum of 60% of total energy requirements.
Comments:
- Recommended dosage depends on age, energy expenditure, clinical status, body weight, tolerance, ability to metabolize, and consideration of additional energy given to the patient.
- Take energy supplied by dextrose and amino acids, as well as enteral nutrition into account when determining dose.
- Correct severe fluid and electrolyte disorders prior to administration.
- The daily dose should not exceed 60% of total energy requirements.
- Obtain a baseline serum triglyceride level; if triglycerides are elevated, initiate at a lower dosage and advance in smaller increments, monitoring triglyceride levels with each adjustment.
Use: Parenteral nutrition when oral or enteral nutrition is not possible, insufficient or contraindicated
Usual Pediatric Dose for Dietary Supplement
Birth to 2 years old (including preterm and term infants):
Initial dose: 0.5 to 1 g/kg/day
- Increase the dose by 0.5 to 1 g/kg/day
- Duration of infusion: 20 to 24 hours for preterm and term neonates, and 12 to 24 hours for patients 1 month to 2 years
2 years to less than 12 years old:
Initial dose: 1 to 2 g/kg/day
- Increase the dose by 0.5 to 1 g/kg/day
- Duration of infusion: 12 to 24 hours
12 to 17 years old:
Initial dose: 1 to 2 g/kg/day
Maximum dose: 2.5 g/kg/day
- Duration of infusion: 12 to 24 hours
Comments:
- Recommended dosage depends on age, energy expenditure, clinical status, body weight, tolerance, ability to metabolize, and consideration of additional energy given to the patient.
- The duration of infusion will vary depending on the clinical situation but infuse over a longer duration in neonates.
- Do not exceed an infusion rate of 0.15 g/kg/h.
- The administration flow rate is determined by dividing the volume of lipid by the duration of the infusion.
Use: Parenteral nutrition when oral or enteral nutrition is not possible, insufficient or contraindicated
Renal Dose Adjustments
Data not available
- Aluminum toxicity may develop in patients with impaired kidney function.
Liver Dose Adjustments
Use with caution.
- Monitor liver function closely, as hepatobiliary disorders are known to develop in some patients.
Precautions
CONTRAINDICATIONS:
- Known hypersensitivity to fish, egg, soybean, peanut protein, or to any of the active or inactive ingredients- Severe disorders of lipid metabolism characterized by hypertriglyceridemia (serum triglyceride >1,000 mg/dL)
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Administration advice:
- This product is for intravenous infusion only into a peripheral or central vein.
- When given with dextrose and amino acids, the choice of central or peripheral administration should depend on the osmolarity of the final infusion:
- If osmolarity is 900 mOsm/L or higher it must be infused through a central vein.
- Less than 900 mOsm/L may be administered either through central or peripheral vein.
- Use a dedicated line for parenteral nutrition.
- Use a 1.2 micron in-line filter.
Storage requirements:
- Once removed from the overpouch, store at 2C to 8C (36F to 46F) for no longer than 24 hours.
Reconstitution/preparation techniques:
- Read the US FDA-approved patient labeling for further preparation and administration instructions.
Monitoring:
- The lipids in this product may interfere with some blood tests (e.g. hemoglobin, lactate dehydrogenase, bilirubin, and oxygen saturation) if blood is sampled before lipids have cleared from the bloodstream.
- Lipids are normally cleared 5 to 6 hours after the lipid infusion is stopped.
- Monitor fluid status closely in patients with pulmonary edema or heart failure.
- Routinely monitor serum triglycerides, fluid and electrolyte status, blood glucose, liver and kidney function, blood count including platelets, and coagulation parameters throughout treatment.
- Monitoring for signs and symptoms of essential fatty acid deficiency (EFAD) is recommended.
- Consult reference values of serum fatty acid level tests to determine adequacy of essential fatty acid status.
- Increasing essential fatty acid intake (enterally or parenterally) is effective in treating EFAD.
Patient advice:
- Read the Patient Information and Instructions for Use.
More about fat emulsion
- Check interactions
- Compare alternatives
- Side effects
- During pregnancy
- Drug class: intravenous nutritional products
Patient resources
- Fat emulsion advanced reading
- Fat emulsion and soybean oil (Advanced Reading)
- Fat emulsion, fish oil, and soybean oil (Advanced Reading)
- Fat Emulsion (Plant Based)
Other brands
SMOFlipid, Intralipid, Omegaven, Clinolipid, Nutrilipid
Professional resources
Other brands
SMOFlipid, Intralipid, Liposyn II
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.