Skip to main content

Fat emulsion Side Effects

Medically reviewed by Last updated on Jul 18, 2023.

Applies to fat emulsion: intravenous emulsion.

Serious side effects of Fat emulsion

Along with its needed effects, fat emulsion may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking fat emulsion:

More common

  • Blurred vision
  • dry mouth
  • flushed, dry skin
  • fruit-like breath odor
  • increased hunger
  • increased thirst
  • increased urination
  • nausea
  • sweating
  • trouble breathing
  • unexplained weight loss
  • unusual tiredness or weakness
  • vomiting

Less common

  • Bladder pain
  • bloody or cloudy urine
  • chills
  • confusion
  • difficult, burning, or painful urination
  • dizziness
  • fainting
  • fever
  • frequent urge to urinate
  • headache
  • lower back or side pain
  • nervousness
  • pale skin
  • pounding in the ears
  • rapid, shallow breathing
  • slow or fast heartbeat
  • unusual bleeding or bruising


  • Chest pain or tightness
  • changes in skin color
  • clay-colored stools
  • cough
  • dark urine
  • eye pain
  • general feeling of illness
  • itching, skin rash
  • loss of appetite
  • pain, tenderness, or swelling of the foot or leg
  • sneezing
  • sore throat
  • unpleasant breath odor
  • vomiting of blood
  • yellow eyes or skin

Incidence not known

  • Black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • blue lips, fingernails, or skin
  • bluish color
  • chest tightness
  • confusion
  • difficulty in swallowing
  • irregular heartbeat
  • muscle cramps, pain, or tremors
  • numbness, tingling, pain, or weakness in the hands or feet
  • pinpoint red spots on the skin
  • problems with bleeding or clotting
  • restlessness
  • sores, ulcers, or white spots on the lips or in the mouth
  • stomach cramps
  • swelling of the face, throat, or tongue
  • swollen glands
  • trouble breathing
  • upper right abdominal or stomach pain and fullness

Other side effects of Fat emulsion

Some side effects of fat emulsion may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Acid or sour stomach
  • belching
  • bloated
  • excess air or gas in the stomach or intestines
  • full feeling
  • heartburn
  • indigestion
  • passing gas
  • stomach discomfort or upset


  • Change in taste
  • loss of taste

Incidence not known

  • Increased sweating

For Healthcare Professionals

Applies to fat emulsion: intravenous emulsion.


Adult patients:

Common (1% to 10%): Hypertension

Uncommon (0.1% to 1%): Tachycardia

Pediatric patients:

Common (1% to 10%): Tachycardia

Uncommon (0.1% to 1%): Hypertension


Frequency not reported: Palpitations, phlebitis[Ref]


Adult patients:

Common (1% to 10%): Nausea, vomiting, flatulence, abdominal pain, dyspepsia

Uncommon (0.1% to 1%): Diarrhea

Pediatric patients:

Common (1% to 10%): Vomiting, diarrhea, abdominal pain[Ref]


Adult patients:

Uncommon (0.1% to 1%): Rash, pruritus

Pediatric patients:

Uncommon (0.1% to 1%): Rash


Frequency not reported: Hyperhidrosis[Ref]


The most common adverse events in pediatric patients were anemia, vomiting, increased gamma-glutamyl transferase, and nosocomial infection.


Adult patients:

Common (1% to 10%): Urinary tract infection[Ref]


Adult patients:

Common (1% to 10%): Increased blood bilirubin

Uncommon (0.1% to 1%): Cholestasis, liver function test abnormalities, increased gamma-glutamyl transferase

Frequency not reported: Cholecystitis, cholelithiasis

Pediatric patients:

Common (1% to 10%): Increased gamma-glutamyl transferase, cholestasis, hyperbilirubinemia, increased conjugated bilirubin, increased alanine aminotransferase

Uncommon (0.1% to 1%): liver function test abnormalities


Frequency not reported: Cholestasis[Ref]


Adult patients

Common (1% to 10%): Anemia

Uncommon (0.1% to 1%): Leukocytosis, increased C-reactive protein

Pediatric patients:

Very common (10% or more): Anemia

Common (1% to 10%): Thrombocytopenia, increased C-reactive protein[Ref]

Nervous system

Adult patients:

Frequency not reported: Dysgeusia, headache, dizziness[Ref]


Adult patients:

Common (1% to 10%): Hyperglycemia, increased blood triglycerides

Uncommon (0.1% to 1%): Increased alkaline phosphatase

Pediatric patients:

Common (1% to 10%): Hyperglycemia

Uncommon (0.1% to 1%): Increased alkaline phosphatase, metabolic acidosis, increased blood triglycerides


Frequency not reported: Fatty acid deficiency[Ref]


Adult patients:

Common (1% to 10%): Pyrexia, fever, device related infections, sepsis

Pediatric patients:

Common (1% to 10%): Nosocomial infection, pyrexia, sepsis

Uncommon (0.1% to 1%): Infection, fluid overload


Frequency not reported: Chills, malaise[Ref]


Adult patients:

Uncommon (0.1% to 1%): Dyspnea, pneumonia


Frequency not reported: Dyspnea, chest pain[Ref]


1. Product Information. Intralipid (fat emulsion, intravenous). Baxter I.V. Systems Division. 2018.

2. Product Information. Smoflipid (fat emulsion, intravenous). Fresenius Kabi USA, LLC. 2018.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.