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Lamprene Side Effects

Generic name: clofazimine

Medically reviewed by Last updated on Apr 10, 2024.

Note: This document contains side effect information about clofazimine. Some dosage forms listed on this page may not apply to the brand name Lamprene.

Applies to clofazimine: oral capsules.

Side effects include:

Discoloration of skin, eyes, urine, feces, sputum, sweat, tears; GI effects (abdominal and epigastric pain, diarrhea, nausea, vomiting, GI intolerance); eye irritation, itching, dryness, burning.

For Healthcare Professionals

Applies to clofazimine: oral capsule.


The most common adverse reactions reported in 40% to 50% of patients included skin and body fluid discoloration, abdominal and epigastric pain, diarrhea, nausea, vomiting, and gastrointestinal intolerance.[Ref]


Frequency not reported: Thromboembolism, vascular pain, QT prolongation


Very common (10% or more): Skin discoloration (up to 100%), ichthyosis (up to 28%), dryness (up to 28%), rash (up to 5%), pruritus (up to 5%)

Frequency not reported: Phototoxicity, erythroderma, acneiform eruptions, monilial cheilosis


Very common (10% or more): Gastrointestinal intolerance (up to 50%), abdominal/epigastric pain (up to 50%), diarrhea (up to 50%), nausea (up to 50%), vomiting (up to 50%)

Frequency not reported: Abdominal/bowel obstruction, abdominal/epigastric pain, diarrhea, nausea, vomiting, bowel obstruction, gastrointestinal bleeding, constipation, eosinophilic enteritis


Frequency not reported: Elevated erythrocyte sedimentation rate, elevated albumin, eosinophilia, anemia


Frequency not reported: Elevated serum bilirubin, elevated AST, hepatitis, jaundice, enlarged liver


Frequency not reported: Elevated blood sugar, hypokalemia, edema


Frequency not reported: Bone pain

Nervous system

Frequency not reported: Dizziness, drowsiness, headache, neuralgia, taste disorder


Frequency not reported: Diminished vision, conjunctival and corneal pigmentation due to clofazimine (the active ingredient contained in Lamprene) crystal deposits, dryness, burning, itching, irritation, maculopathy (bull's eye retinopathy)


Frequency not reported: Discoloration of urine, feces, sputum, and sweat, splenic infarction, fever, lymphadenopathy, anorexia, weight loss, fatigue, giddiness


Frequency not reported: Depression and suicide secondary to skin discoloration


Frequency not reported: Cystitis


1. (2019) "Product Information. Lamprene (clofazimine)." Novartis Pharmaceuticals

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.