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Lamprene Side Effects

Generic name: clofazimine

Medically reviewed by Drugs.com. Last updated on Apr 10, 2024.

Note: This document contains side effect information about clofazimine. Some dosage forms listed on this page may not apply to the brand name Lamprene.

Applies to clofazimine: oral capsules.

Side effects include:

Discoloration of skin, eyes, urine, feces, sputum, sweat, tears; GI effects (abdominal and epigastric pain, diarrhea, nausea, vomiting, GI intolerance); eye irritation, itching, dryness, burning.

For Healthcare Professionals

Applies to clofazimine: oral capsule.

General

The most common adverse reactions reported in 40% to 50% of patients included skin and body fluid discoloration, abdominal and epigastric pain, diarrhea, nausea, vomiting, and gastrointestinal intolerance.[Ref]

Cardiovascular

Frequency not reported: Thromboembolism, vascular pain, QT prolongation

Dermatologic

Very common (10% or more): Skin discoloration (up to 100%), ichthyosis (up to 28%), dryness (up to 28%), rash (up to 5%), pruritus (up to 5%)

Frequency not reported: Phototoxicity, erythroderma, acneiform eruptions, monilial cheilosis

Gastrointestinal

Very common (10% or more): Gastrointestinal intolerance (up to 50%), abdominal/epigastric pain (up to 50%), diarrhea (up to 50%), nausea (up to 50%), vomiting (up to 50%)

Frequency not reported: Abdominal/bowel obstruction, abdominal/epigastric pain, diarrhea, nausea, vomiting, bowel obstruction, gastrointestinal bleeding, constipation, eosinophilic enteritis

Hematologic

Frequency not reported: Elevated erythrocyte sedimentation rate, elevated albumin, eosinophilia, anemia

Hepatic

Frequency not reported: Elevated serum bilirubin, elevated AST, hepatitis, jaundice, enlarged liver

Metabolic

Frequency not reported: Elevated blood sugar, hypokalemia, edema

Musculoskeletal

Frequency not reported: Bone pain

Nervous system

Frequency not reported: Dizziness, drowsiness, headache, neuralgia, taste disorder

Ocular

Frequency not reported: Diminished vision, conjunctival and corneal pigmentation due to clofazimine (the active ingredient contained in Lamprene) crystal deposits, dryness, burning, itching, irritation, maculopathy (bull's eye retinopathy)

Other

Frequency not reported: Discoloration of urine, feces, sputum, and sweat, splenic infarction, fever, lymphadenopathy, anorexia, weight loss, fatigue, giddiness

Psychiatric

Frequency not reported: Depression and suicide secondary to skin discoloration

Renal

Frequency not reported: Cystitis

References

1. (2019) "Product Information. Lamprene (clofazimine)." Novartis Pharmaceuticals

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.