Skip to Content
Vaccines aren’t just for kids. Is your teen protected?

Clofazimine Pregnancy and Breastfeeding Warnings

Clofazimine is also known as: Lamprene

Clofazimine Pregnancy Warnings

In one reported case of clofazimine administration throughout gestation, hyperpigmentation was reported in the infant. In addition, the placenta showed signs of amnionitis. At two weeks, the infant was diagnosed with bilateral hydrocele and iron deficiency anemia. Another case of clofazimine use throughout pregnancy reported no complications.

Clofazimine has been assigned to pregnancy category C by the FDA. While some animal studies have failed to reveal evidence of teratogenicity, studies done at high doses have demonstrated fetotoxicity. There are no controlled data in human pregnancy. Skin pigmentation has been noted in infants born to women treated with clofazimine during pregnancy. Clofazimine is only recommended during pregnancy when benefit outweighs risk.

See references

Clofazimine Breastfeeding Warnings

Clofazimine is excreted into human milk. Skin pigmentation is reported in at least one nursing infant. Clofazimine should not be used during breast-feeding unless necessary.

See references

References for pregnancy information

  1. Farb H, West DP, Pedvis-Leftick A "Clofazimine in pregnancy complicated by leprosy." Obstet Gynecol 59 (1982): 122-3
  2. "Product Information. Lamprene (clofazimine)." Novartis Pharmaceuticals, East Hanover, NJ.

References for breastfeeding information

  1. "Product Information. Lamprene (clofazimine)." Novartis Pharmaceuticals, East Hanover, NJ.

See Also...

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and Drugs.com is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2008 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.

Hide