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Imetelstat Side Effects

Medically reviewed by Drugs.com. Last updated on Aug 10, 2024.

Applies to imetelstat: intravenous powder for injection.

Important warnings This medicine can cause some serious health issues

Imetelstat can make it easier for you to bleed, even from a minor injury.

Call your doctor if you have bleeding that will not stop.

Bleeding may also happen inside your body, such as in your stomach or intestines, or in your brain.

You may get infections more easily, even serious or fatal infections.

Call your doctor if you have flu symptoms, cough, night sweats, neck stiffness, confusion, or vision problems.

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Some side effects may occur during the injection. Tell your medical caregiver if you feel dizzy, nauseated, light-headed, itchy, sweaty, or have a headache, chest tightness, back pain, trouble breathing, or swelling in your face.

Tell your medical caregivers right away if you have:

Your imetelstat treatments may be changed, delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For healthcare professionals

Applies to imetelstat: intravenous powder for injection.

General adverse events

Most common adverse reactions occurring in at least 10% of patients included laboratory abnormalities are decreased platelets, decreased white blood cells, decreased neutrophils, increased AST, increased alkaline phosphatase, increased ALT, fatigue, prolonged partial thromboplastin time, arthralgia/myalgia, coronavirus disease 2019 (COVID-19) infections, and headache.[Ref]

Cardiovascular

Dermatologic

Gastrointestinal

Hematologic

Hepatic

Immunologic

Infusion-related reactions included abdominal pain, arthralgia, asthenia, back pain, bone pain, diarrhea, erythema, headache, hypertensive crisis, malaise, non-cardiac chest pain, pruritus, and urticaria.

Metabolic

Musculoskeletal

Nervous system

Other

Renal

References

1. (2024) "Product Information. Rytelo (imetelstat)." Geron Corporation

Further information

Imetelstat side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.