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HyperRAB S / D Side Effects

Generic Name: rabies immune globulin, human

Note: This page contains information about the side effects of rabies immune globulin, human. Some of the dosage forms included on this document may not apply to the brand name HyperRAB S / D.

For the Consumer

Applies to rabies immune globulin, human: intramuscular solution

In addition to its needed effects, some unwanted effects may be caused by rabies immune globulin, human (the active ingredient contained in HyperRAB S / D). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking rabies immune globulin, human:

  • Cloudy or bloody urine
  • high blood pressure
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • swelling of the face, feet, or lower legs

Minor Side Effects

Some of the side effects that can occur with rabies immune globulin, human may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common:
  • Fever
  • pain, soreness, tenderness, or stiffness at the injection site
  • Skin rash

For Healthcare Professionals

Applies to rabies immune globulin, human: intramuscular solution


The most common adverse events were injection site and skin reactions.[Ref]


Rare (less than 0.1%): Injection site: swelling, pain, erythema, induration, warmth, pruritus, rash
Frequency not reported: Discomfort at injection site, soreness at injection site[Ref]


Rare (less than 0.1%): Skin reaction, erythema, pruritus, skin rash
Frequency not reported: Angioneurotic edema, bruising[Ref]


Rare (less than 0.1%): Hypersensitivity, anaphylactic shock, allergic type reactions[Ref]


Rare (less than 0.1%): Fever, malaise, chill, fatigue, influenza like illness
Frequency not reported: Mild temperature elevations, disabling pain that limited motion[Ref]


Rare (less than 0.1%): Nephrotic syndrome[Ref]


Rare (less than 0.1%): Tachycardia, hypotension[Ref]


Rare (less than 0.1%): Arthralgia
Frequency not reported: Compartment syndrome, infiltration of wounds[Ref]


Rare (less than 0.1%): Nausea, vomiting[Ref]

Nervous system

Rare (less than 0.1%): Headache[Ref]


Frequency not reported: Sensitization to repeated injections[Ref]


1. "Product Information. Imogam Rabies-HT (rabies immune globulin, human)." sanofi pasteur, Swiftwater, PA.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. "Product Information. Hyperrab S/D (rabies immune globulin, human)." Grifols Therapeutics, Clayton, NC.

4. Cerner Multum, Inc. "Australian Product Information." O 0

Not all side effects for HyperRAB S / D may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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