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Hydrocortisone / neomycin / polymyxin b topical Side Effects

Medically reviewed by Last updated on Jul 7, 2022.

Applies to hydrocortisone/neomycin/polymyxin b topical: external cream.

Serious side effects

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of a weak adrenal gland like a very bad upset stomach or throwing up, very bad dizziness or passing out, muscle weakness, feeling very tired, mood changes, not hungry, or weight loss.
  • Signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or breath that smells like fruit.
  • Very bad skin irritation.
  • Skin changes (pimples, stretch marks, slow healing, hair growth).
  • Skin breakdown where this drug is used.
  • Not able to pass urine or change in how much urine is passed.
  • Change in hearing.

Other side effects

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Skin irritation.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

For Healthcare Professionals

Applies to hydrocortisone/neomycin/polymyxin b topical: topical cream.


The possibility of systemic side effects should be considered when steroid preparations are used for a long period of time.[Ref]



-Frequency not reported: Skin sensitization

Topical Corticosteroids:

-Frequency not reported: Striae[Ref]


Topical corticosteroids:

-Frequency not reported: Burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, miliaria[Ref]


Frequency not reported: Allergic sensitization[Ref]



-Frequency not reported: Nephrotoxicity[Ref]



-Frequency not reported: Ototoxicity[Ref]

More about hydrocortisone / neomycin / polymyxin b topical

Patient resources

Related treatment guides


1. "Product Information. Cortisporin Cream (hydrocortisone/neomycin/polymyxin B topical)." Monarch Pharmaceuticals Inc (2022):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.