Skip to Content

Humegon Side Effects

Generic Name: menotropins

Note: This page contains information about the side effects of menotropins. Some of the dosage forms included on this document may not apply to the brand name Humegon.

For the Consumer

Applies to menotropins: subcutaneous injection

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Headache; nausea; pain, swelling, heat, or redness at the injection site; stomach cramps, fullness, or pain; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur while taking menotropins (the active ingredient contained in Humegon)

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); breast pain or enlarged breasts; calf, leg, or arm pain, swelling, redness, or tenderness; change in balance; change in color of skin to a bluish color (eg, on the lips, nail beds, fingers, toes); changes in speech or vision; chest, jaw, or arm pain; confusion; coughing up blood; fainting; fast breathing; fast heartbeat; flu-like symptoms; one-sided weakness; pale skin; shortness of breath; sudden, severe nausea or vomiting; unusual sweating; weakness; yellowing of the skin or eyes.

For Healthcare Professionals

Applies to menotropins: injectable powder for injection, intramuscular powder for injection, subcutaneous powder for injection


The most frequently reported adverse drug reactions reported are abdominal pain, headache, injection site reactions, and injection site pain[Ref]


Very common (10% or more): Multiple pregnancy (35.3%)
Common (1% to 10%): Ovarian Hyperstimulation Syndrome (OHSS), abnormal ovarian enlargement, ovarian disease, vaginal hemorrhage, pelvic pain, breast pain, ectopic pregnancy
Postmarketing reports: Ovarian cyst, breast complaints (including breast tenderness, breast discomfort and breast swelling)
Frequency not reported: Ovarian torsion[Ref]


Common (1% to 10%): Abdominal pain, abdominal cramps, enlarged abdomen, nausea and vomiting, diarrhea, fullness and pain
Postmarketing reports: Nausea, abdominal pain lower, abdominal distension, abdominal discomfort
Frequency not reported: Diarrhea[Ref]


Common (1% to 10%): Infection
Frequency not reported: Formation of antibodies[Ref]


Common (1% to 10%): Injection site pain/reaction, injection site inflammation, injection site edema[Ref]

Nervous system

Common (1% to 10%): Headache
Postmarketing reports: Dizziness[Ref]


Common (1% to 10%): Dyspnea[Ref]


Uncommon (0.1% to 1%): Thrombophlebitis, deep vein thrombosis
Postmarketing reports: Hot flush[Ref]


Frequency not reported: Hypersensitivity[Ref]


Postmarketing reports: Acne, rash, pruritus[Ref]


Postmarketing reports: Arthralgia[Ref]


Postmarketing reports: Visual disorders (blurred vision, vision impairment including amaurosis, diplopia, mydriasis, photopsia, scotoma and vitreous floaters)[Ref]


Postmarketing reports: Fatigue, pyrexia[Ref]


1. "Product Information. Repronex (menotropins)." Ferring Pharmaceuticals Inc, Tarrytown, NY.

2. "Product Information. Menopur (menotropins)." Ferring Pharmaceuticals Inc, Tarrytown, NY.

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

4. Cerner Multum, Inc. "Australian Product Information." O 0

Not all side effects for Humegon may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.