Hetastarch Side Effects
Medically reviewed by Drugs.com. Last updated on April 19, 2021.
For the Consumer
Applies to hetastarch: parenteral injection
Side effects include:
Hypersensitivity reactions, coagulopathy, hemodilution, circulatory overload, metabolic acidosis, CHF, pulmonary edema, bleeding, vomiting, peripheral edema, submaxillary and parotid glandular enlargement, mild influenza-like symptoms, headache, muscle pain.
For Healthcare Professionals
Applies to hetastarch: intravenous solution
Frequency not reported: Vomiting[Ref]
Frequency not reported: Intracranial bleeding, bleeding and/or anemia due to hemodilution and/or Factor VIII deficiency, acquired von Willebrand's-like syndrome, coagulopathy (including rare cases of disseminated intravascular coagulopathy and hemolysis)[Ref]
Frequency not reported: Death, life-threatening anaphylactic/anaphylactoid reactions, cardiac arrest, ventricular fibrillation, severe hypotension, non-cardiac pulmonary edema, laryngeal edema, bronchospasm, angioedema, wheezing, restlessness, tachypnea, stridor, fever, chest pain, bradycardia, tachycardia, shortness of breath, chills, urticaria, pruritus, facial and periorbital edema, coughing, sneezing, flushing erythema multiforme, rash[Ref]
Frequency not reported: Metabolic acidosis[Ref]
Frequency not reported: Muscle pain[Ref]
Frequency not reported: Submaxillary and parotid glandular enlargement, mild influenza-like symptoms, headaches, hydroxyethyl starch-associated pruritus in patients with deposits of hydroxyethyl starch in peripheral nerves[Ref]
Frequency not reported: Pulmonary edema[Ref]
-The most common adverse reactions are hypersensitivity, coagulopathy, hemodilution, circulatory overload and metabolic acidosis.
-Serious adverse events reported in clinical trials are increased mortality and renal replacement therapy in critically ill patients.[Ref]
Frequency not reported: Need for renal replacement therapy[Ref]
1. "Product Information. Hextend (hetastarch)." Abbott Pharmaceutical, Abbott Park, IL.
2. "Product Information. Hespan (hetastarch)." B. Braun Medical, Irvine, CA.
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Some side effects may not be reported. You may report them to the FDA.