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Hetastarch Side Effects

For the Consumer

Applies to hetastarch: parenteral injection

Side effects include:

Hypersensitivity reactions, coagulopathy, hemodilution, circulatory overload, metabolic acidosis, CHF, pulmonary edema, bleeding, vomiting, peripheral edema, submaxillary and parotid glandular enlargement, mild influenza-like symptoms, headache, muscle pain.

For Healthcare Professionals

Applies to hetastarch: intravenous solution

Cardiovascular

Frequency not reported: Circulatory overload, congestive heart failure, pulmonary edema, peripheral edema of the lower extremities[Ref]

Gastrointestinal

Frequency not reported: Vomiting[Ref]

Hematologic

Frequency not reported: Intracranial bleeding, bleeding and/or anemia due to hemodilution and/or Factor VIII deficiency, acquired von Willebrand's-like syndrome, coagulopathy (including rare cases of disseminated intravascular coagulopathy and hemolysis)[Ref]

Hypersensitivity

Frequency not reported: Death, life-threatening anaphylactic/anaphylactoid reactions, cardiac arrest, ventricular fibrillation, severe hypotension, non-cardiac pulmonary edema, laryngeal edema, bronchospasm, angioedema, wheezing, restlessness, tachypnea, stridor, fever, chest pain, bradycardia, tachycardia, shortness of breath, chills, urticaria, pruritus, facial and periorbital edema, coughing, sneezing, flushing erythema multiforme, rash[Ref]

Metabolic

Frequency not reported: Metabolic acidosis[Ref]

Musculoskeletal

Frequency not reported: Muscle pains[Ref]

Other

Frequency not reported: Submaxillary and parotid glandular enlargement, mild influenza-like symptoms, headaches, hydroxyethyl starch-associated pruritus in patients with deposits of hydroxyethyl starch in peripheral nerves[Ref]

References

1. "Product Information. Hespan (hetastarch)." B. Braun Medical, Irvine, CA.

2. "Product Information. Hextend (hetastarch)." Abbott Pharmaceutical, Abbott Park, IL.

Not all side effects for hetastarch may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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