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Heparin flush Side Effects

For the Consumer

Applies to heparin flush: injection solution, intravenous solution

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of bleeding like throwing up blood or throw up that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; vaginal bleeding that is not normal; bruises without a reason or that get bigger; or any bleeding that is very bad or that you cannot stop.
  • Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
  • Very bad dizziness or passing out.
  • Swelling, warmth, numbness, change of color, or pain in a leg or arm.
  • Change in skin color where the shot was given.
  • Feeling confused.
  • Very bad headache.
  • Chills.
  • Fever.
  • Chest pain.
  • Back pain.
  • Shortness of breath.
  • Redness or swelling where the shot is given.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Irritation where the shot is given.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

For Healthcare Professionals

Applies to heparin flush: intravenous kit, intravenous solution

Hematologic

Hematologic side effects have included new thrombus formation in association with thrombocytopenia resulting from irreversible aggregation of platelets induced by heparin, the so-called "white clot syndrome". The process may lead to severe thromboembolic complications like skin necrosis, gangrene of the extremities that may lead to amputation, myocardial infarction, pulmonary embolism, stroke, and possibly death. Thrombocytopenia has been reported to occur in patients receiving heparin with a reported incidence of 0 to 30%.[Ref]

Hypersensitivity

Hypersensitivity side effects include the remote possibility of hypersensitivity reaction from the entry of extremely small subtherapeutic amounts of the heparin flush solution into the circulation. Such an occurrence has not been reported.[Ref]

References

1. "Product Information. Heparin Lock Flush (heparin flush)." Hospira Inc, Lake Forest, IL.

Some side effects of heparin flush may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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