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Heparin flush Pregnancy and Breastfeeding Warnings

Heparin flush is also known as: Hep-Lock, Heparin Lock Flush, Monoject Prefill Advanced, PosiFlush

Heparin flush Pregnancy Warnings

Heparin has been assigned to pregnancy category C by the FDA. Animal studies have not been conducted and there are no controlled data in human pregnancy. It does not cross the placenta due to its large molecular weight (3,000 to 30,000 daltons). Heparin is considered the anticoagulant of choice during pregnancy, although anticoagulation and maternal disease state may pose a risk to both the mother and fetus. Heparin is only recommended for use during pregnancy when benefit outweighs risk.

See references

Heparin flush Breastfeeding Warnings

Heparin is not excreted into human milk due to its large molecular weight (3,000 to 30,000 daltons). Heparin is considered compatible with breast-feeding.

See references

References for pregnancy information

  1. Chan WS, Anand S, Ginsberg JS "Anticoagulation of pregnant women with mechanical heart valves - A systematic review of the literature." Arch Intern Med 160 (2000): 191-6
  2. Nageotte MP, Freeman RK, Garite TJ, Block RA "Anticoagulation in pregnancy." Am J Obstet Gynecol 141 (1981): 472-3
  3. Masamoto H, Toma T, Sakumoto K, Kanazawa K "Clearance of antiphospholipid antibodies in pregnancies treated with heparin - Reply." Obstet Gynecol 98 (2001): 162
  4. Bergqvist A, Bergqvist D, Hallbook T "Deep vein thrombosis during pregnancy." Acta Obstet Gynecol Scand 62 (1983): 443-8
  5. Fausett MB, Vogtlander M, Lee RM, Esplin MS, Branch DW, Rodgers GM, Silver RM "Heparin-induced thrombocytopenia is rare in pregnancy." Am J Obstet Gynecol 185 (2001): 148-52
  6. Flessa HC, Kapstrom AB, Glueck HI, Will JJ "Placental transport of heparin." Am J Obstet Gynecol 93 (1965): 570-3
  7. Aarskog D, Aksnes L, Markestad T, Ulstein M, Sagen N "Heparin-induced inhibition of 1,25-dihydroxyvitamin D formation." Am J Obstet Gynecol 148 (1984): 1141-2
  8. McIntyre JA, Wagenknecht DR, Faulk WP "Clearance of antiphospholipid antibodies in pregnancies treated with heparin." Obstet Gynecol 98 (2001): 162
  9. Toglia MR, Weg JG "Venous thromboembolism during pregnancy." N Engl J Med 335 (1996): 108-14
  10. Ginsburg JS, Kowalchuk G, Hirsh J, Brill-Edwards P, Burrows R "Heparin therapy during pregnancy." Arch Intern Med 149 (1989): 2233-6
  11. "Product Information. Heparin Lock Flush (heparin flush)." Hospira Inc, Lake Forest, IL.
  12. Hall JG, Pauli RM, Wilson KM "Maternal and fetal sequelae of anticoagulation during pregnancy." Am J Med 68 (1980): 122-40
  13. Howell R, Fidler J, Letsky E, De Swiet M "The risks of antenatal subcutaneous heparin prophylaxis: a controlled trial." Br J Obstet Gynaecol 90 (1983): 1124-8

References for breastfeeding information

  1. "Product Information. Heparin Lock Flush (heparin flush)." Hospira Inc, Lake Forest, IL.
  2. Ginsberg JS, Hirsh J "Use of antithrombotic agents during pregnancy." Chest 108 Suppl (1995): s305-11

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