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Fluoxymesterone Side Effects

For the Consumer

Applies to fluoxymesterone: oral tablet

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using fluoxymesterone and call your doctor at once if you have:

  • shortness of breath (even with mild exertion), swelling, rapid weight gain;

  • increased or ongoing erection of the penis;

  • nausea, vomiting, loss of appetite, increased thirst, muscle weakness, confusion, and feeling tired or restless; or

  • upper stomach pain, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Women receiving fluoxymesterone may develop male characteristics, which could be irreversible if testosterone treatment is continued. Stop taking this medication and call your doctor at once if you notice any of these signs of excess testosterone:

  • changes in menstrual periods;

  • male-pattern hair growth (such as on the chin or chest);

  • hoarse voice; or

  • enlarged clitoris.

Common side effects (in men or women) may include:

  • acne, changes in skin color;

  • increased hair growth;

  • male pattern baldness;

  • increased or decreased interest in sex;

  • breast swelling;

  • headache, anxiety, depression; or

  • numbness, burning, pain, or tingly feeling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to fluoxymesterone: compounding powder, oral tablet


Rare (less than 0.1%): Hepatocellular neoplasms, peliosis hepatis, hepatic coma
Frequency not reported: Cholestatic jaundice, alterations in liver function tests[Ref]


Frequency not reported: Females: Virilization, gonadotropin secretion inhibition, amenorrhea and other menstrual irregularities; Males: Gynecomastia, oligospermia, penile erections of excessive frequency and duration[Ref]


Frequency not reported: Increased serum cholesterol; retention of sodium, chloride, water, potassium, calcium, and inorganic phosphates[Ref]


Frequency not reported: Polycythemia; suppression of clotting factors II, V, VII, and X; bleeding in patients on concomitant anticoagulant therapy[Ref]


Frequency not reported: Hirsutism, male pattern baldness, acne[Ref]


Frequency not reported: Nausea[Ref]

Nervous system

Frequency not reported: Headache, generalized paresthesia[Ref]


Rare (less than 0.1%): Anaphylactoid reactions
Frequency not reported: Hypersensitivity reactions[Ref]


Frequency not reported: Increased or decreased libido, anxiety, depression[Ref]


1. "Product Information. Androxy (fluoxymesterone)." Upsher-Smith Laboratories Inc, Minneapolis, MN.

Not all side effects for fluoxymesterone may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.