Ergotamine Side Effects

Medically reviewed by Drugs.com. Last updated on Nov 21, 2024.

Applies to ergotamine: oral tablets, rectal suppositories, sublingual tablets.

Important warnings This medicine can cause some serious health issues

• Possible serious and/or life-threatening cerebral and/or peripheral ischemia when used concomitantly with potent CYP3A4 inhibitors (see Interactions); concomitant use contraindicated.^{138 139 140}

Side effects include:

Nausea, vomiting, abdominal pain, numbness and tingling of the fingers and toes, muscle pain in the extremities, weakness in the legs.

For healthcare professionals

Applies to ergotamine: compounding powder, sublingual tablet.

General adverse events

The most commonly reported adverse effects have included nausea and vomiting.^[Ref]

Nervous system

• Rare (less than 0.1%): Cerebral ischemia
• Frequency not reported: Paresthesias, numbness, weakness

Reports of cerebral ischemia, including 1 death, have been reported for patients receiving ergotamine and protease inhibitors concomitantly. A black box warning is now required labeling for these drugs.

Cardiovascular

• Frequency not reported: Ischemia, cyanosis, absence of pulse, cold extremities, precordial distress, EKG changes, gangrene, transient tachycardia, bradycardia, hypertension

Serious vasoconstrictive have occurred, more commonly with long-term therapy at relatively high doses, however, they have been reported with short-term or normal doses.

Gastrointestinal

• Frequency not reported: Nausea, vomiting

Musculoskeletal

• Frequency not reported: Musculoskeletal aches, pains, and cramps

Other

• Frequency not reported: Vertigo

Hypersensitivity

• Frequency not reported: Localized edema, itching

Further information

Ergotamine side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer