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Cortisporin Otic Side Effects

Generic Name: hydrocortisone / neomycin / polymyxin b otic

Note: This document contains side effect information about hydrocortisone / neomycin / polymyxin b otic. Some of the dosage forms listed on this page may not apply to the brand name Cortisporin Otic.

In Summary

More frequent side effects include: idiopathic edema, pruritus, skin rash, erythema, and local irritation. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to hydrocortisone/neomycin/polymyxin b otic: otic solution, otic suspension

Along with its needed effects, hydrocortisone/neomycin/polymyxin b otic may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking hydrocortisone/neomycin/polymyxin b otic:

More common
  • Itching, skin rash, redness, swelling, or other signs of irritation in or around the ear not present before the use of this medicine
  • Stinging and burning feeling in the middle ear
Incidence not known
  • Blood in the urine
  • change in the frequency of urination or amount of urine
  • difficulty in breathing
  • dizziness
  • drowsiness
  • feeling of fullness in the ears
  • increased thirst
  • loss of appetite
  • loss of balance
  • loss of hearing
  • nausea
  • ringing or buzzing in the ears
  • swelling of the feet or lower legs
  • trouble in hearing
  • vomiting
  • weakness

Some side effects of hydrocortisone/neomycin/polymyxin b otic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Cough
  • difficulty swallowing
  • fast heartbeat
  • hives, itching, skin rash
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • tightness in the chest
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to hydrocortisone/neomycin/polymyxin b otic: otic solution, otic suspension


Rare (less than 0.1%): Application site hypersensitivity[Ref]


Rare (less than 0.1%): Local exfoliative dermatitis, skin atrophy, telangiectasia , stria, exacerbation of underlying skin conditions (including eczema)
Frequency not reported: Folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, miliaria[Ref]


The most commonly reported side effect was hypersensitivity.[Ref]

Nervous system

Frequency not reported: Ototoxicity[Ref]


Frequency not reported: Secondary infection[Ref]


Rare (less than 0.1%): Application site reaction including pain, irritation, edema, burning sensation, rash
Frequency not reported: Itching, dryness, stinging[Ref]


Frequency not reported: Nephrotoxicity[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Cortisporin Otic (hydrocortisone/neomycin/polymyxin B otic)" Monarch Pharmaceuticals Inc, Bristol, TN.

Some side effects of Cortisporin Otic may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.