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Cortisporin Cream Side Effects

Generic Name: hydrocortisone / neomycin / polymyxin b topical

Note: This page contains information about the side effects of hydrocortisone / neomycin / polymyxin b topical. Some of the dosage forms included on this document may not apply to the brand name Cortisporin Cream.

For the Consumer

Applies to hydrocortisone / neomycin / polymyxin b topical: cream

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dryness; itching.

Seek medical attention right away if any of these SEVERE side effects occur while taking hydrocortisone / neomycin / polymyxin b topical:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); acne-like rash; burning or peeling of the skin not present when you began using hydrocortisone/neomycin/polymyxin b cream; changes in hearing; decreased urination; excessive hair growth; inflamed hair follicles; inflammation around the mouth; loss of hearing; muscle weakness; increased or persistent pain, redness, irritation, or swelling; thinning, softening, or discoloration of the skin; unusual weight gain, especially in the face.

For Healthcare Professionals

Applies to hydrocortisone / neomycin / polymyxin b topical: topical cream


Dermatologic side effects associated with the use of topical corticosteroids have included burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, and miliaria. These reactions are more likely with the use of occlusive dressings or with long-term use.[Ref]


Hypersensitivity reactions have been associated with the anti-infective component of this drug and are manifested by itching and swelling. Neomycin is known to cause contact sensitivity with an estimated incidence of 0.09% to 1%.[Ref]

Nervous system

Nervous system side effects have included ototoxicity associated with the use of neomycin.[Ref]


Renal side effects have included nephrotoxicity associated with the use of neomycin.[Ref]


1. "Product Information. Cortisporin Topical (hydrocortisone/neomycin/polymyxin B topical)." Monarch Pharmaceuticals Inc, Bristol, TN.

Not all side effects for Cortisporin Cream may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

More about Cortisporin Cream (hydrocortisone / neomycin / polymyxin b topical)

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