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Conivaptan Side Effects

For the Consumer

Applies to conivaptan: intravenous solution

In addition to its needed effects, some unwanted effects may be caused by conivaptan. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking conivaptan, check with your doctor or nurse immediately:

More common:
  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the site
  • bloating or swelling of the face, arms, hands, lower legs, ankles, or feet
  • blurred vision
  • decreased urine
  • dizziness
  • dry mouth
  • headache
  • increased thirst
  • irregular heartbeat
  • loss of appetite
  • mood changes
  • muscle pain or cramps
  • nausea or vomiting
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • pounding in the ears
  • rapid weight gain
  • seizures
  • slow or fast heartbeat
  • tingling of hands or feet
  • unusual tiredness or weakness
  • unusual weight gain or loss
Less common:
  • Abdominal or stomach pain
  • bladder pain
  • bloody or cloudy urine
  • bluish color
  • change in consciousness
  • changes in skin color
  • chest pain
  • cold sweats
  • confusion
  • cool pale skin
  • cough
  • decreased urination
  • depression
  • difficult, burning, or painful urination
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • drowsiness
  • fainting
  • fear
  • fever or chills
  • flushed, dry skin
  • frequent urge to urinate
  • fruit-like breath odor
  • increase in amount of urine
  • increase in heart rate
  • increased hunger
  • increased urination
  • loss of consciousness
  • lower back or side pain
  • mental changes
  • muscle spasms [tetany] or twitching
  • nightmares
  • pale skin
  • problems in urination
  • rapid breathing
  • shakiness
  • slurred speech
  • sneezing
  • sore mouth or tongue
  • sore throat
  • sunken eyes
  • sweating
  • swelling of the foot or leg
  • tenderness
  • thirst
  • tightness in the chest
  • trembling
  • trouble sleeping
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • white patches in the mouth or on the tongue
  • wrinkled skin

Minor Side Effects

Some of the side effects that can occur with conivaptan may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Diarrhea
Less common:
  • Difficulty having a bowel movement (stool)
  • redness of the skin
  • unusually warm skin

For Healthcare Professionals

Applies to conivaptan: intravenous solution

General

The most frequently reported side effects were infusion site reactions (including phlebitis), pyrexia, hypokalemia, headache, and orthostatic hypotension.[Ref]

Cardiovascular

Very common (10% or more): Cardiac failure event (32%), orthostatic hypotension (up to 14%)
Common (1% to 10%): Atrial fibrillation, hypertension, hypotension, atrial dysrhythmia[Ref]

During clinical trials, this drug was administered to patients who were hypervolemic and hyponatremic with underlying heart failure. Adverse cardiac failure events (32%), atrial dysrhythmias (5%), and sepsis (8%) occurred more frequently in this patient population treated with this drug compared to those treated with placebo.[Ref]

Local

Very common (10% or more): Infusion site phlebitis (up to 51%), infusion site reaction (up to 22%)
Common (1% to 10%): Infusion site erythema, infusion site pain[Ref]

Metabolic

Very common (10% or more): Hypokalemia (up to 22%)
Common (1% to 10%): Hypomagnesemia, hyponatremia[Ref]

Other

Very common (10% or more): Pyrexia (up to 11%)
Common (1% to 10%): Peripheral edema, thirst, post procedural diarrhea, electrocardiogram ST segment depression, sepsis[Ref]

Nervous system

Very common (10% or more): Headache (up to 10%)
Frequency not reported: Osmotic demyelination syndrome[Ref]

Gastrointestinal

Common (1% to 10%): Constipation, diarrhea, nausea, vomiting[Ref]

Hematologic

Common (1% to 10%): Anemia[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection[Ref]

Psychiatric

Common (1% to 10%): Confusional state, insomnia[Ref]

Dermatologic

Common (1% to 10%): Pruritus[Ref]

Respiratory

Common (1% to 10%): Pneumonia, pharyngolaryngeal pain[Ref]

References

1. "Product Information. Vaprisol (conivaptan)." Cumberland Pharmaceuticals Inc, Nashville, TN.

Not all side effects for conivaptan may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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