Codeine / pyrilamine Side Effects
For the Consumer
Applies to codeine / pyrilamine: oral syrup
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Very bad dizziness or passing out.
- Chest pain or pressure or a fast heartbeat.
- Trouble breathing, slow breathing, or shallow breathing.
- Noisy breathing.
- Feeling very sleepy.
- Feeling confused.
- A heartbeat that does not feel normal.
- Hallucinations (seeing or hearing things that are not there).
- Mood changes.
- Seizures.
- Very bad belly pain.
- Very bad headache.
- Trouble passing urine.
- Shakiness.
- Change in eyesight.
- Very upset stomach or throwing up.
- Very hard stools (constipation).
- Feeling very tired or weak.
What are some other side effects of this drug?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Feeling sleepy.
- Feeling nervous and excitable.
- Hard stools (constipation).
- Dizziness.
- Upset stomach or throwing up.
- Sweating a lot.
- Feeling tired or weak.
- Dry mouth.
- Dry nose.
- Thickening of mucus in nose or throat.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
For Healthcare Professionals
Applies to codeine/pyrilamine: oral liquid
General
The most common side effects may include drowsiness, dizziness, and dry mouth.[Ref]
Respiratory
Frequency not reported: Respiratory depression
Nervous system
Frequency not reported: Drowsiness
Gastrointestinal
Frequency not reported: Constipation, dry mouth
Psychiatric
Frequency not reported: Excitability
Cardiovascular
Codeine:
Frequency not reported: blood pressure changes, syncope
Genitourinary
Frequency not reported: Urinary retention
Ocular
Frequency not reported: Blurred vision
References
1. "Product Information. Pro-Clear AC (codeine-pyrilamine)." Pro-Pharma LLC, Kirksville, MO.
2. "American Geriatrics Society 2015 Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults." J Am Geriatr Soc 63 (2015): 2227-46
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.
