Clomid Side Effects
Generic name: clomiphene
Medically reviewed by Drugs.com. Last updated on Oct 24, 2022.
Note: This document contains side effect information about clomiphene. Some dosage forms listed on this page may not apply to the brand name Clomid.
Applies to clomiphene: oral tablets.
Side effects include:
Ovarian enlargement; abdominal or pelvic discomfort including distention, bloating, or pain; hot flushes (flashes).
For Healthcare Professionals
Applies to clomiphene: compounding powder, oral tablet.
At recommended doses, this drug is well tolerated. Most side effects have been mild and transient and disappear promptly after treatment has stopped.[Ref]
Very common (10% or more): Ovarian enlargement (up to 13.6%), vasomotor flushes (10.4%)
Common (1% to 10%): Abdominal/pelvic discomfort/distention/bloating, breast discomfort, uterine bleeding abnormal, intermenstrual spotting, menorrhagia
Frequency not reported: Urinary frequency increased, urinary volume increased, vaginal dryness
Postmarketing reports: Endometriosis, ovarian hemorrhage, tubal pregnancy, uterine hemorrhage, reduced endometrial thickness, ovarian hemorrhage, tubal pregnancy, uterine hemorrhage, endometrial thickness reduced
-Postmarketing reports: Hypospadias, cloacal exstrophy[Ref]
Common (1% to 10%): Blurred vision, lights, floaters, waves, unspecified visual complaints, photophobia, diplopia, scotomata, phosphenes
Postmarketing reports: Abnormal accommodation, cataract, eye pain, macular edema, optic neuritis, photopsia, posterior vitreous detachment, retinal hemorrhage, retinal thrombosis, retinal vascular spasm, temporary or prolonged loss of vision
-Postmarketing reports: Eye malformed, lens malformed/cataract[Ref]
-Postmarketing reports: Septal heart defect, muscular ventricular septal defect, patent ductus arteriosus, tetralogy of Fallot, coarctation of aorta[Ref]
Postmarketing reports: Thyroid disorder
-Postmarketing reports: Dwarfism[Ref]
Frequency not reported: Ovarian cancer, ovarian tumor
Postmarketing reports: Ovarian cyst, hepatic hemangiosarcoma, liver cell adenoma, hepatocellular carcinoma, fibrocystic disease, breast carcinoma, endometrial carcinoma, astrocytoma, pituitary tumor, prolactinoma, neurofibromatosis, glioblastoma multiforme, brain abscess, ovary (luteoma of pregnancy, dermoid cyst of the ovary, ovarian carcinoma, hydatiform mole, choriocarcinoma, melanoma, myeloma, perianal cysts, renal cell carcinoma, Hodgkin's lymphoma, tongue carcinoma, bladder carcinoma
Common (1% to 10%): Headache
Frequency not reported: Dizziness, lightheadedness
Postmarketing reports: Pancreatitis
Postmarketing reports: Increased transaminases, hepatitis[Ref]
Frequency not reported: Appetite increased, serum desmosterol levels increase
Postmarketing reports: Hypertriglyceridemia[Ref]
-Postmarketing reports: Abnormal bone development, skeletal malformations of skull/face/nasal passages/jaw/hand limb/foot/spine/joints[Ref]
Postmarketing reports: Anxiety, irritability, mood changed, psychosis
Postmarketing reports: Intellectual disability[Ref]
-Postmarketing reports: Lung tissue malformation[Ref]
-Postmarketing reports: Renal agenesis, renal dysgenesis[Ref]
Frequently asked questions
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- Drug class: synthetic ovulation stimulants
Related treatment guides
1. Product Information. ClomiPHENE Citrate (clomiPHENE). Teva Pharmaceuticals USA. 2022.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.