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Ciprofloxacin / dexamethasone otic Side Effects

For the Consumer

Applies to ciprofloxacin / dexamethasone otic: otic suspension

In addition to its needed effects, some unwanted effects may be caused by ciprofloxacin / dexamethasone otic. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking ciprofloxacin / dexamethasone otic:

Incidence not known:
  • Cough
  • difficulty with swallowing
  • dizziness
  • fast heartbeat
  • hives, itching, or skin rash
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • tightness in the chest
  • unusual tiredness or weakness

Minor Side Effects

Some of the side effects that can occur with ciprofloxacin / dexamethasone otic may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common:
  • Ear discomfort
  • ear pain
  • itching skin on the ear
  • Bitter, sour, or unusual taste in the mouth
  • ear congestion
  • ear debris
  • ear residue
  • redness of the skin
  • superimposed ear infection (second ear infection)

For Healthcare Professionals

Applies to ciprofloxacin / dexamethasone otic: otic suspension


The most commonly reported side effects in patients with tympanostomy tubes and acute otitis media were ear pain, discomfort, and dysgeusia/tasting medicine.
The most commonly reported side effect in patients with acute otitis externa was ear pruritus.[Ref]


Common (1% to 10%): Ear discomfort, ear pain, ear pruritus
Uncommon (0.1% to 1%): Otorrhea, fatigue, ear congestion, candidiasis/fungal ear infection, crying, superimposed ear infection, device/tympanostomy tube blockage/occlusion, ear precipitate/residue/debris/medication residue present
Rare (0.01% to 0.1%): Hypoacusis, tinnitus
Frequency not reported: decreased hearing, ear disorder
Postmarketing reports: Auricular swelling[Ref]

Nervous system

Uncommon (0.1% to 1%): Taste perversion/dysgeusia, paresthesia/tingling in ears
Rare (0.01% to 0.1%): Dizziness, headache[Ref]


Uncommon (0.1% to 1%): Erythema, flushing
Rare (0.01% to 0.1%): Rash erythematous
Postmarketing reports: Skin exfoliation[Ref]


Uncommon (0.1% to 1%): Vomiting
Frequency not reported: Oral moniliasis[Ref]


Uncommon (0.1% to 1%): Irritability[Ref]


Postmarketing reports: Hypersensitivity[Ref]


1. "Product Information. Ciprodex (ciprofloxacin-dexamethasone otic)." Alcon Laboratories Inc, Fort Worth, TX.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Not all side effects for ciprofloxacin / dexamethasone otic may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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