Carbaglu Side Effects
Generic name: carglumic acid
Medically reviewed by Drugs.com. Last updated on May 9, 2025.
Note: This document provides detailed information about Carbaglu Side Effects associated with carglumic acid. Some dosage forms listed on this page may not apply specifically to the brand name Carbaglu.
Applies to carglumic acid: oral tablet for suspension.
Precautions
It is very important that your doctor check your or your child's progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects.
Hyperammonemia (too much ammonia in the blood) is a life-threatening condition that requires immediate medical attention. Check with your doctor right away if you or your child have nausea or vomiting that continues, an increase in the frequency of seizures, loss of appetite, swelling of the face, tiredness and weakness, or yellow eyes or skin.
Serious side effects of Carbaglu
Along with its needed effects, carglumic acid (the active ingredient contained in Carbaglu) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking carglumic acid:
More common side effects
- black, tarry stools
- chills
- cough
- decreased weight
- diarrhea
- fever
- general feeling of discomfort or illness
- headache
- hoarseness
- increased sweating
- joint pain
- loss of appetite
- lower back or side pain
- muscle aches and pains
- nausea
- painful or difficult urination
- pale skin
- runny nose
- shivering
- sore throat
- sweating
- trouble sleeping
- trouble breathing
- ulcers, sores, or white spots in the mouth
- unusual bleeding or bruising
- unusual tiredness or weakness
- vomiting
Less common side effects
- agitation
- anxiety
- bloating
- blurred vision
- chest discomfort or pain
- cold sweats
- coma
- confusion
- cool, pale skin
- darkened urine
- decreased appetite
- decreased awareness or responsiveness
- depression
- dizziness
- drowsiness
- faintness
- hallucinations
- indigestion
- irritability
- mood or mental changes
- nervousness
- nightmares
- numbness, tingling, pain, or weakness in the hands or feet
- pains in the stomach, side, or abdomen, possibly radiating to the back
- seizures
- severe sleepiness
- shakiness
- slurred speech
- stiff neck
- swelling of the feet or lower legs
- trembling
- weakness and heaviness of the legs
- yellow eyes or skin
Incidence not known
- actions that are out of control
- itching, rash
- reddened skin
- talking, feeling, and acting with excitement
Get emergency help immediately if any of the following symptoms of overdose occur while taking carglumic acid:
Symptoms of overdose
- fast, pounding, or irregular heartbeat or pulse
- increase in mucous from the lungs
- restlessness
Other side effects of Carbaglu
Some side effects of carglumic acid may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common side effects
- change in hearing
- change in taste
- congestion
- ear drainage
- earache or pain in the ear
- lack or loss of strength
- loss of taste
- sleepiness or unusual drowsiness
- stomach pain
- stuffy or runny nose
- swollen glands
See also:
For healthcare professionals
Applies to carglumic acid: oral tablet dispersible.
General adverse events
The more commonly reported adverse reactions have included vomiting, abdominal pain, pyrexia, and infection.[Ref]
Gastrointestinal
- Very common (10% or more): Vomiting (26%), abdominal pain (17%), tonsillitis (17%), diarrhea (13%)
- Common (1% to 10%): Dysgeusia[Ref]
Metabolic
- Common (1% to 10%): Decreased weight, anorexia, hyperglycemia[Ref]
Immunologic
Hematologic
- Very common (10% or more): Anemia (13%), decreased hemoglobin (13%)
- Common (1% to 10%): Thrombocytopenia[Ref]
Nervous system
- Very common (10% or more): Headache (13%)
- Common (1% to 10%): Somnolence[Ref]
Dermatologic
- Common (1% to 10%): Hyperhidrosis, rash
- Postmarketing reports: Pruritus, rash including rash erythematous, rash maculopapular, rash pustular[Ref]
Hepatic
- Common (1% to 10%): Increased transaminases
Respiratory
- Very common (10% or more): Nasopharyngitis (13%)
- Common (1% to 10%): Pneumonia, oxygen saturation decreased
Other
- Very common (10% or more): Pyrexia (17%), ear infection (13%)
- Common (1% to 10%): Asthenia
Cardiovascular
- Common (1% to 10%): Cardiac murmur
- Uncommon (0.1% to 1%): Bradycardia
Psychiatric
- Postmarketing reports: Mania
References
1. Cerner Multum, Inc. "Australian Product Information."
2. (2010) "Product Information. Carbaglu (carglumic acid)." Accredo Health Group Inc
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Further information
Carbaglu side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.