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Calcium phosphate, tribasic Side Effects

For the Consumer

Applies to calcium phosphate, tribasic: oral tablet


Do not take calcium phosphate or antacids that contain calcium without first asking your doctor if you also take other medicines. Calcium can make it harder for your body to absorb certain medicines.

Calcium phosphate works best if you take it with food.

Get emergency medical help if you have any of these signs of an allergic reaction while taking calcium phosphate, tribasic: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects of calcium phosphate, tribasic may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to calcium phosphate, tribasic: oral tablet


Gastrointestinal side effects have included nausea in up to 9% of patients receiving calcium phosphate with vitamin D and fluoride.[Ref]


Metabolic side effects have included hyperphosphatemia and hypercalciuria. Hypercalcemia has been reported with some calcium salts; however, it has not yet been associated with the use of calcium phosphate.[Ref]

Metabolic changes associated with some calcium salts include hypercalcemia, although this has not yet been associated with the use of calcium phosphate.

Hyperphosphatemia can result from overuse.

Prolonged calcium administration of some calcium salts has rarely resulted in hypercalciuria. This may be more likely in patients with hypoparathyroidism who are receiving vitamin D.[Ref]


Cardiovascular side effects have included a single case report of systemic tricalcium phosphate crystallosis involving the heart (myocarditis and pericarditis).[Ref]


1. Hasling C, Nielsen HE, Melsen F, Mosekilde L "Safety of osteoporosis treatment with sodium fluoride, calcium phosphate and vitamin D." Miner Electrolyte Metab 13 (1987): 96-103

2. Edelson GW, Kleerekoper M "Hypercalcemic crisis." Med Clin North Am 79 (1995): 79-92

3. Cleghorn GJ, Tudehope DI "Neonatal intestinal obstruction associated with oral calcium supplementation." Aust Paediatr J 17 (1981): 298-9

4. Knowles JB, Cusson G, Smith M, Sitrin MD "Pulmonary deposition of calcium phosphate crystals as a complication of home total parenteral nutrition." JPEN J Parenter Enteral Nutr 13 (1989): 209-13

5. Chaudhuri TK, Chaudhuri TuH "Calcium phosphate colloid: possible nidus for metastatic calcification in hypercalcemia." JAMA 222 (1972): 1061

6. Breuer RI, LeBauer J "Caution in the use of phosphates in the treatment of severe hypercalcemia." J Clin Endocrinol Metab 27 (1967): 695-8

7. Reimann HA, Imbriglia JE, Ducanes T "Crystal-induced myocarditis and pericarditis." Am J Cardiol 17 (1966): 269-72

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.