Ayvakit Side Effects

Generic name: avapritinib

Medically reviewed by Drugs.com. Last updated on Oct 23, 2023.

Note: This document contains side effect information about avapritinib. Some dosage forms listed on this page may not apply to the brand name Ayvakit.

Applies to avapritinib: oral tablet.

Serious side effects of Ayvakit

Along with its needed effects, avapritinib (the active ingredient contained in Ayvakit) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking avapritinib:

More common

Bladder pain
bloody or cloudy urine
blurred vision
body aches or pain
chest tightness
defects in intelligence, short-term memory, learning ability, and attention
dizziness
ear congestion
headache
loss of voice
lower back or side pain
mood or mental changes
nervousness
pale skin
pounding in the ears
runny or stuffy nose
slow or fast heartbeat
sneezing
sore throat
trouble sleeping
trouble with breathing
unusual bleeding or bruising
unusual tiredness or weakness

Less common

Agitation
black, tarry stools
bloody stools
chest pain
chills
confusion
constipation
cough
decreased awareness or responsiveness
decreased urine output
depressed mood
difficult, burning, or painful urination
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
dry skin and hair
dilated neck veins
fainting
feeling cold
fever
frequent urge to urinate
gaseous stomach pain
hair loss
hoarseness or husky voice
hostility
increased sensitivity of the skin to sunlight
irritability
lightheadedness
loss of consciousness
muscle cramps, stiffness, and twitching
nausea
pounding in the ears
rapid weight gain
rapid, shallow breathing
redness or other discoloration of the skin
seizures
sensitivity to heat
severe sleepiness
severe sunburn
skin rash
sneezing
sore throat
stomach pain and bloating
sweating
swelling of the face, ankles, or hands
swelling of the finger, feet, or lower legs
unusual drowsiness, dullness, or feeling of sluggishness
vomiting of blood or material that looks like coffee grounds
weight gain or loss
yellow eyes or skin

Other side effects of Ayvakit

Some side effects of avapritinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Bad unusual or unpleasant (after)taste
belching
change in taste
decreased appetite
diarrhea
difficulty in moving
feeling of warmth
redness of the face, neck, arms and occasionally, upper chest
hair color changes
heartburn
increased tearing
indigestion
muscle pain or stiffness
pain in the joints
skin rash
stomach discomfort, upset, or pain
swelling of the eye, eyelid, or inner lining of the eyelid
vomiting

Less common

Redness or pain of the skin
scaling of the skin on the hands and feet
tingling of the hands and feet
ulceration of the skin

For Healthcare Professionals

Applies to avapritinib: oral tablet.

Hematologic

Very common (10% or more): Hemoglobin decreased (81%), leukocytes decreased (62%), neutrophils decreased (43%), platelets decreased (27%), international normalized ratio (INR) increased (24%), activated partial thromboplastin time increased (13%)^[Ref]

Ocular

Very common (10% or more): Increased lacrimation (33%)^[Ref]

Metabolic

Very common (10% or more): Anorexia (38%), phosphate decreased (49%), potassium decreased (34%), albumin decreased (31%), magnesium decreased (29%), sodium decreased (28%), weight loss (13%)^[Ref]

Psychiatric

Very common (10% or more): Cognitive impairment (48%), sleep disorders (e.g., insomnia, somnolence, sleep disorder) (15%), mood disorders (e.g., agitation, anxiety, depression, depressed mood, dysphoria, irritability, mood altered,

nervousness, personality change, suicidal ideation) (13%)

Common (1% to 10%): Speech disorders, hallucinations^[Ref]

Hepatic

Very common (10% or more): Bilirubin increased (69%), aspartate aminotransferase increased (51%), alkaline phosphatase increased (14%)^[Ref]

Respiratory

Very common (10% or more): Dyspnea (17%), pleural effusion (12%)^[Ref]

Other

Very common (10% or more): Edema (e.g., face swelling, conjunctival edema, eye edema, eyelid edema, orbital edema, periorbital edema, face edema, mouth edema, pharyngeal edema, peripheral edema, edema, generalized edema, localized edema, peripheral swelling, testicular edema) (72%), fatigue/asthenia (61%), pyrexia (14%)^[Ref]

General

The most common adverse reactions (20% or greater) were edema, nausea, fatigue/asthenia, cognitive impairment, vomiting, decreased appetite, diarrhea, hair color changes, increased lacrimation, abdominal pain, constipation, rash, and dizziness.^[Ref]

Nervous system

Very common (10% or more): Dizziness (22%), headache (17%), taste effects (e.g., dysgeusia, ageusia) (15%)^[Ref]

Renal

Very common (10% or more): Creatinine increased (29%)^[Ref]

Cardiovascular

Common (1% to 10%): Intracranial hemorrhage (e.g., subdural hematoma, intracranial hemorrhage, cerebral hemorrhage)^[Ref]

Dermatologic

Very common (10% or more): Rash (e.g., rash, rash maculopapular, rash erythematous, rash macular, rash generalized, rash papular) (23%), hair color changes (21%), alopecia (13%)

Common (1% to 10%): Palmar-plantar erythrodysesthesia^[Ref]

Endocrine

Common (1% to 10%): Thyroid disorders (e.g., hyperthyroid, hypothyroid)^[Ref]

Gastrointestinal

Very common (10% or more): Nausea (64%), vomiting (38%), diarrhea (37%), abdominal pain (e.g., abdominal pain, upper abdominal pain, abdominal discomfort, lower abdominal pain, abdominal tenderness, epigastric discomfort) (31%), constipation (23%), dyspepsia (16%)^[Ref]