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Ayvakit Side Effects

Generic name: avapritinib

Medically reviewed by Drugs.com. Last updated on Feb 20, 2023.

Note: This document contains side effect information about avapritinib. Some dosage forms listed on this page may not apply to the brand name Ayvakit.

Applies to avapritinib: oral tablet.

Serious side effects of Ayvakit

Along with its needed effects, avapritinib (the active ingredient contained in Ayvakit) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking avapritinib:

More common

Less common

Other side effects of Ayvakit

Some side effects of avapritinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to avapritinib: oral tablet.

Hematologic

Very common (10% or more): Hemoglobin decreased (81%), leukocytes decreased (62%), neutrophils decreased (43%), platelets decreased (27%), international normalized ratio (INR) increased (24%), activated partial thromboplastin time increased (13%)[Ref]

Ocular

Very common (10% or more): Increased lacrimation (33%)[Ref]

Metabolic

Very common (10% or more): Anorexia (38%), phosphate decreased (49%), potassium decreased (34%), albumin decreased (31%), magnesium decreased (29%), sodium decreased (28%), weight loss (13%)[Ref]

Psychiatric

Very common (10% or more): Cognitive impairment (48%), sleep disorders (e.g., insomnia, somnolence, sleep disorder) (15%), mood disorders (e.g., agitation, anxiety, depression, depressed mood, dysphoria, irritability, mood altered,

nervousness, personality change, suicidal ideation) (13%)

Common (1% to 10%): Speech disorders, hallucinations[Ref]

Hepatic

Very common (10% or more): Bilirubin increased (69%), aspartate aminotransferase increased (51%), alkaline phosphatase increased (14%)[Ref]

Respiratory

Very common (10% or more): Dyspnea (17%), pleural effusion (12%)[Ref]

Other

Very common (10% or more): Edema (e.g., face swelling, conjunctival edema, eye edema, eyelid edema, orbital edema, periorbital edema, face edema, mouth edema, pharyngeal edema, peripheral edema, edema, generalized edema, localized edema, peripheral swelling, testicular edema) (72%), fatigue/asthenia (61%), pyrexia (14%)[Ref]

General

The most common adverse reactions (20% or greater) were edema, nausea, fatigue/asthenia, cognitive impairment, vomiting, decreased appetite, diarrhea, hair color changes, increased lacrimation, abdominal pain, constipation, rash, and dizziness.[Ref]

Nervous system

Very common (10% or more): Dizziness (22%), headache (17%), taste effects (e.g., dysgeusia, ageusia) (15%)[Ref]

Renal

Very common (10% or more): Creatinine increased (29%)[Ref]

Cardiovascular

Common (1% to 10%): Intracranial hemorrhage (e.g., subdural hematoma, intracranial hemorrhage, cerebral hemorrhage)[Ref]

Dermatologic

Very common (10% or more): Rash (e.g., rash, rash maculopapular, rash erythematous, rash macular, rash generalized, rash papular) (23%), hair color changes (21%), alopecia (13%)

Common (1% to 10%): Palmar-plantar erythrodysesthesia[Ref]

Endocrine

Common (1% to 10%): Thyroid disorders (e.g., hyperthyroid, hypothyroid)[Ref]

Gastrointestinal

Very common (10% or more): Nausea (64%), vomiting (38%), diarrhea (37%), abdominal pain (e.g., abdominal pain, upper abdominal pain, abdominal discomfort, lower abdominal pain, abdominal tenderness, epigastric discomfort) (31%), constipation (23%), dyspepsia (16%)[Ref]

References

1. Product Information. Ayvakit (avapritinib). Blueprint Medicines Corporation. 2020.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.