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Ayvakit Side Effects

Generic name: avapritinib

Medically reviewed by Drugs.com. Last updated on Jul 6, 2021.

Note: This document contains side effect information about avapritinib. Some of the dosage forms listed on this page may not apply to the brand name Ayvakit.

For the Consumer

Applies to avapritinib: oral tablet

Side effects requiring immediate medical attention

Along with its needed effects, avapritinib (the active ingredient contained in Ayvakit) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking avapritinib:

More common

  • Bladder pain
  • bloody or cloudy urine
  • blurred vision
  • body aches or pain
  • chest tightness
  • defects in intelligence, short-term memory, learning ability, and attention
  • dizziness
  • ear congestion
  • headache
  • loss of voice
  • lower back or side pain
  • mood or mental changes
  • nervousness
  • pale skin
  • pounding in the ears
  • runny or stuffy nose
  • slow or fast heartbeat
  • sneezing
  • sore throat
  • trouble sleeping
  • trouble with breathing
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Less common

  • Agitation
  • black, tarry stools
  • bloody stools
  • chest pain
  • chills
  • confusion
  • constipation
  • cough
  • decreased awareness or responsiveness
  • decreased urine output
  • depressed mood
  • difficult, burning, or painful urination
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • dry skin and hair
  • dilated neck veins
  • fainting
  • feeling cold
  • fever
  • frequent urge to urinate
  • gaseous stomach pain
  • hair loss
  • hoarseness or husky voice
  • hostility
  • irritability
  • lightheadedness
  • loss of consciousness
  • muscle cramps, stiffness, and twitching
  • nausea
  • pounding in the ears
  • rapid weight gain
  • rapid, shallow breathing
  • seizures
  • sensitivity to heat
  • severe sleepiness
  • sneezing
  • sore throat
  • stomach pain and bloating
  • sweating
  • swelling of the face, ankles, or hands
  • swelling of the finger, feet, or lower legs
  • unusual drowsiness, dullness, or feeling of sluggishness
  • vomiting of blood or material that looks like coffee grounds
  • weight gain or loss
  • yellow eyes or skin

Side effects not requiring immediate medical attention

Some side effects of avapritinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Bad unusual or unpleasant (after)taste
  • belching
  • change in taste
  • decreased appetite
  • diarrhea
  • difficulty in moving
  • hair color changes
  • heartburn
  • increased tearing
  • indigestion
  • muscle pain or stiffness
  • pain in the joints
  • skin rash
  • stomach discomfort, upset, or pain
  • vomiting

Less common

  • Redness or pain of the skin
  • scaling of the skin on the hands and feet
  • tingling of the hands and feet
  • ulceration of the skin

For Healthcare Professionals

Applies to avapritinib: oral tablet

Hematologic

Very common (10% or more): Hemoglobin decreased (81%), leukocytes decreased (62%), neutrophils decreased (43%), platelets decreased (27%), international normalized ratio (INR) increased (24%), activated partial thromboplastin time increased (13%)[Ref]

Ocular

Very common (10% or more): Increased lacrimation (33%)[Ref]

Metabolic

Very common (10% or more): Anorexia (38%), phosphate decreased (49%), potassium decreased (34%), albumin decreased (31%), magnesium decreased (29%), sodium decreased (28%), weight loss (13%)[Ref]

Psychiatric

Very common (10% or more): Cognitive impairment (48%), sleep disorders (e.g., insomnia, somnolence, sleep disorder) (15%), mood disorders (e.g., agitation, anxiety, depression, depressed mood, dysphoria, irritability, mood altered,

nervousness, personality change, suicidal ideation) (13%)

Common (1% to 10%): Speech disorders, hallucinations[Ref]

Hepatic

Very common (10% or more): Bilirubin increased (69%), aspartate aminotransferase increased (51%), alkaline phosphatase increased (14%)[Ref]

Respiratory

Very common (10% or more): Dyspnea (17%), pleural effusion (12%)[Ref]

Other

Very common (10% or more): Edema (e.g., face swelling, conjunctival edema, eye edema, eyelid edema, orbital edema, periorbital edema, face edema, mouth edema, pharyngeal edema, peripheral edema, edema, generalized edema, localized edema, peripheral swelling, testicular edema) (72%), fatigue/asthenia (61%), pyrexia (14%)[Ref]

General

The most common adverse reactions (20% or greater) were edema, nausea, fatigue/asthenia, cognitive impairment, vomiting, decreased appetite, diarrhea, hair color changes, increased lacrimation, abdominal pain, constipation, rash, and dizziness.[Ref]

Nervous system

Very common (10% or more): Dizziness (22%), headache (17%), taste effects (e.g., dysgeusia, ageusia) (15%)[Ref]

Renal

Very common (10% or more): Creatinine increased (29%)[Ref]

Cardiovascular

Common (1% to 10%): Intracranial hemorrhage (e.g., subdural hematoma, intracranial hemorrhage, cerebral hemorrhage)[Ref]

Dermatologic

Very common (10% or more): Rash (e.g., rash, rash maculopapular, rash erythematous, rash macular, rash generalized, rash papular) (23%), hair color changes (21%), alopecia (13%)

Common (1% to 10%): Palmar-plantar erythrodysesthesia[Ref]

Endocrine

Common (1% to 10%): Thyroid disorders (e.g., hyperthyroid, hypothyroid)[Ref]

Gastrointestinal

Very common (10% or more): Nausea (64%), vomiting (38%), diarrhea (37%), abdominal pain (e.g., abdominal pain, upper abdominal pain, abdominal discomfort, lower abdominal pain, abdominal tenderness, epigastric discomfort) (31%), constipation (23%), dyspepsia (16%)[Ref]

References

1. "Product Information. Ayvakit (avapritinib)." Blueprint Medicines Corporation, Cambridge, MA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.