Adenovirus Vaccine Side Effects

Medically reviewed by Drugs.com. Last updated on Feb 20, 2025.

Applies to adenovirus vaccine: oral tablets.

Side effects include:

Upper respiratory tract infection, headache, nasal congestion, pharyngolaryngeal pain (sore throat), cough, arthralgia, GI effects (abdominal pain, nausea, diarrhea, vomiting).

For healthcare professionals

Applies to adenovirus vaccine: oral tablet.

General adverse events

The most common adverse events were upper respiratory tract infections, headache, nasal congestion, pharyngolaryngeal pain, cough, arthralgia, nausea, abdominal pain, diarrhea, and vomiting.^[Ref]

Respiratory

• Very common (10% or more): Nasal congestion (15.3%), pharyngolaryngeal pain (12.9%), cough (12.4%)
• Common (1% to 10%): Rhinorrhea^[Ref]

Gastrointestinal

• Very common (10% or more): Abdominal pain upper (14.6%), nausea (13.6%), diarrhea (10.2%)
• Rare (less than 0.1%): Gastroenteritis, febrile gastroenteritis, gastritis, hematochezia^[Ref]

Other

• Very common (10% or more): Upper respiratory tract infection (37.5%)
• Common (1% to 10%): Pyrexia (temperature of 100.5F or higher), pain in extremity^[Ref]

Nervous system

• Very common (10% or more): Headache (29.5%)^[Ref]

Musculoskeletal

• Very common (10% or more): Arthralgia (17.3%)
• Common (1% to 10%): Chills^[Ref]

Immunologic

• Rare (less than 0.1%): Pneumonia, appendicitis^[Ref]

Genitourinary

• Rare (less than 0.1%): Hematuria^[Ref]

See also:

Further information

Adenovirus vaccine side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer