Medically reviewed by Drugs.com. Last updated on Jun 4, 2020.
(na ta MYE sin)
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Natacyn: 5% (15 mL)
Brand Names: U.S.
- Antifungal Agent, Ophthalmic
Binds to sterol in fungal cell membrane and changes the cell wall permeability allowing for a reduction of cellular contents
Ophthalmic: Systemic, not expected; Gastrointestinal: Poor
Adheres to cornea, retained in conjunctival fornices; does not produce effective intraocular fluid concentrations
Use: Labeled Indications
Ocular fungal infections: Treatment of fungal blepharitis, conjunctivitis, and keratitis caused by susceptible organisms, including Fusarium solani keratitis.
Hypersensitivity to natamycin or any component of the formulation
Fungal keratitis: Ophthalmic: Instill 1 drop in conjunctival sac every 1 to 2 hours, after 3 to 4 days reduce to one drop 6 to 8 times daily; usual course of therapy is 2 to 3 weeks or until resolution of active fungal keratitis (may be useful to gradually reduce dosage at 4- to 7-day intervals to assure elimination of organism)
Fungal blepharitis or conjunctivitis: Ophthalmic: Instill 1 drop in conjunctival sac 4 to 6 times daily
Refer to adult dosing.
Ophthalmic: For topical ophthalmic use only. Shake well before using. Wash hands before and after use. Do not touch tip of applicator to eye or other surfaces.
Store at 2°C to 24°C (36°F to 75°F); do not freeze. Protect from excessive heat and light.
There are no known significant interactions.
Postmarketing and/or case reports: Allergic reaction, chest pain, corneal opacity, dyspnea, eye discomfort, edema, hyperemia, irritation and/or pain, foreign body sensation, parasthesia, tearing, vision changes
• Epithelial ulceration: Suspension may adhere to epithelial ulcers; retention of the suspension in the fornices occurs regularly.
• Contact lens wearers: Contains benzalkonium chloride, which may be absorbed by soft contact lenses; remove lenses prior to administration. Contact lenses should not be worn during treatment of ophthalmologic infections (including fungal blepharitis, conjunctivitis, and keratitis).
• Appropriate use: For topical ophthalmic use only. Failure to improve (keratitis) after 7 to 10 days of administration suggests infection caused by a microorganism not susceptible to natamycin; efficacy as a single agent in fungal endophthalmitis has not been established.
Animal reproduction studies have not been conducted.
What is this drug used for?
• It is used to treat eye infections.
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
• Vision changes
• Eye pain
• Severe eye irritation
• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
Note: This is not a comprehensive list of all side effects. Talk to your doctor if you have questions.
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More about natamycin ophthalmic
Other brands: Natacyn