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Dimethicone (Topical)

Medically reviewed by Last updated on Apr 10, 2023.

Index Terms

Pharmacologic Category


Forms a protective layer on the skin that acts as a barrier to moisture loss and a protector against repeated hydration and chemical irritants.


Little to no absorption.

Use: Labeled Indications

Skin protectant: To protect and prevent chafed, chapped, cracked, or windburned skin or lips or other minor skin irritations (eg, diaper rash, perineal dermatitis). Product-specific indications may vary; also refer to manufacturer's labeling.


There are no contraindications listed in the manufacturer's labeling.

Dosing: Adult

Skin protectant: Topical: Apply to affected area as needed.

Dosing: Geriatric

Refer to adult dosing.

Dosing: Pediatric

Skin protectant: Infants, Children, and Adolescents: Topical: Apply to affected area(s) as needed.


Topical: For external use only; avoid contact with eyes. Formulation-specific application instructions may vary; also refer to manufacturer's labeling.


Store at room temperature; do not freeze. Avoid excessive heat.

Drug Interactions

There are no known significant interactions.

Adverse Reactions

No ADRs in manufacturer's labeling.


Other warnings/precautions:

• Self-medication (OTC use): For external use only. Avoid contact with eyes; flush with water with accidental contact. Do not apply to animal bites, deep puncture wounds, infected skin, or serious burns. Notify health care provider if symptoms worsen, do not improve within 7 days, or clear up and reoccur within a few days.

Pregnancy Considerations

Dimethicone is not absorbed systemically following topical administration (Nair 2003). Use during pregnancy would not be expected to result in significant exposure to the fetus.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.