Medically reviewed on Nov 15, 2017
Scientific Name(s): Hippophae rhamnoides L. Family: Elaeagnaceae 1
Common Name(s): Sea buckthorn 1
Numerous pharmacological effects are documented in the scientific literature, including antimicrobial, antiulcerogenic, antioxidant, anticancer, radioprotective activity, platelet aggregation, liver injury, cardiovascular risk factors, and effects on skin and mucosa.
Five to 45 g of seed oil and 300 mL/day of juice have been studied in clinical trials.
None well documented.
Avoid use during pregnancy and lactation because clinical trial data are lacking.
Sea buckthorn oil reportedly induces the cytogenetic activity of cyclophosphamide and farmorubicin.
None well documented.
Sea buckthorn has been used as a food in Asia and in Europe. Toxicological studies in animals suggest seed oil and oil from the fruit's soft parts are safe. Acute and chronic toxicity of blood, liver, and heart as well as mutagenicity and teratogenicity of sea buckthorn oils have been studied.
Sea buckthorn is a medium-sized, hardy, deciduous shrub that grows 2 to 6 m in height. It is found along riversides, in mountainous areas, and in sandy and gravel ground at elevations of 3,300 to 4,500 m. The bark is thick and rough. Each leaf is elongate-oblanceolate or elongate-spatulate, green at the top, and silver-ash green on the underside. It flowers in April and the sour, pearl-shaped, yellowish-orange fruits are collected from August to October. There are 9 described subspecies. 1 , 2 , 3 , 4 , 5
The plant is naturally distributed in Central Asia, in Europe from the Black Sea coast to the Alps, and along the shores of northwestern Europe. It also is found in Canada and the United States. 3
Sea buckthorn has a rich history of use in treating numerous medical conditions. It has been called a wonder plant in many Asian countries, including China, India, and Pakistan. The berries have been used for more than 1,000 years in Tibetan and Indian systems of medicine. In traditional Chinese medicine, it has been used to aid digestion and treat cough, circulatory disorders, and pain. 1 , 6 , 7
Because of their hemostatic and anti-inflammatory effects, the fruits are added to prescriptions in Indian and Tibetan medicine to treat pulmonary, GI, cardiac (eg, ischemic heart disease), blood, hepatic, and metabolic disorders. Ancient Tibetan medical literature documents the use of sea buckthorn for fever, inflammation, toxicity, abscesses, cough, colds, clearing sputum, laxative effect, tumors (particularly in the stomach and esophagus), and gynecological diseases. 1 , 2 The flowers are used as a skin softener in Tajikistan. 1 In Mongolia, extracts from the leaves and branches of the plant are used medicinally to treat colitis and enterocolitis in humans and animals. In Middle Asia, the leaves are used to treat GI and skin disorders, and topically applied to treat rheumatoid arthritis. 1 , 2 , 6
In Russia, the oil from the seeds and fruits was used topically to treat chronic dermatoses, eczema, psoriasis, lupus erythematosus, burns, frostbite, and cervical erosion. Oil from the fruit has been used to treat thrombosis. Oil extracts have been used in ophthalmology to treat keratitis, trachoma, conjunctivitis, and injuries or burns of the eyelid. 1
As an economic resource, sea buckthorn is used in a range of products, including oil, juice, cosmetics, shampoos, and as a food additive to candies and jellies. It has been planted extensively to help prevent soil erosion. 8 , 9
Sea buckthorn contains carotenoids, tocopherols, sterols, flavonoids, lipids, ascorbic acid, and tannins.
Flavonols in the leaves, fruit, or juice of sea buckthorn 1 , 10 , 11 , 12 , 13 are noted because of their antioxidant and anticarcinogenic activity. Most occur as C-3 glucosides, rutinosides, and sophorosides.
Flavon-3-ols found in the juice of sea buckthorn include (+) catechin (and +/- gallocatechin) and (-) epicatechin.
Tocopherols and tocotrienols in the fruit or seeds of sea buckthorn, 1 , 8 , 15 collectively known as vitamin E, have antioxidant activity. α-Tocopherol has the highest antioxidant activity and is the most abundant tocopherol, comprising approximately 76% to 89% of the berry.
Carotenoids found in the fruit of sea buckthorn 1 , 16 , 17 , 18 may decrease the risk for age-related macular degeneration and include α-, β-, and γ-carotene; lycopene; zeaxanthin; zeaxanthin dipalmitat; and β-cryptoxanthin palmitate. The antioxidant activity is more potent with extracted sea buckthorn oil because of higher carotenoid levels. Organic acids in the juice of sea buckthorn 1 have been identified as oxalic, citric, tartaric, malic, quinic, and ascorbic acid.
Fatty acid composition differs between the seed oil and soft parts of the fruit. The seed oil contains linoleic, α-linoleic, oleic, palmitic, stearic, and vaccenic acids. The fruit contains palmitoleic, palmitic, and oleic acids. Sterols are found in 1% to 2% of the seed oil and 1% to 3% in the soft parts of the fruit as sitosterol, isofucosterol, campsterol, stigmastanol, citrostadienol, avenasterol, cycloartenol, 24-methylenecycloartanol, and obtusifoliol. 1 , 4 , 19
More than 40 volatile compounds are in the fruit and leaves of sea buckthorn. 1 , 19 , 20 Steam distillation of the fruit yielded 8 aliphatic esters, 9 aliphatic alcohols, and 10 aliphatic hydrocarbons. The primary constituents of the volatile fruit aromas are ethyl dodecenoate, ethyl octanoate, decanol, ethyl decanoate, and ethyl dodecanoate.
The tannins hippophaenins A and B have been isolated from the leaves of sea buckthorn. 21
Uses and PharmacologyAntimicrobial activity
In vitro data
Phenolic compounds from the berries of sea buckthorn inhibited the growth of gram-negative but not gram-positive bacteria. Myricetin inhibited the growth of lactic acid bacteria from human GI tract flora. Extracts from sea buckthorn seeds inhibited the growth of Bacillus cereus (minimum inhibitory concentration or MIC 200 ppm), Bacillus coagulans (MIC 300 ppm), Bacillus subtilis (MIC 300 ppm), Listeria monocytogenes (MIC 300 ppm), and Yersinia enterocolitica (MIC 350 ppm). 22 , 23 Ethanol extracts of sea buckthorn inhibited the growth of Helicobacter pylori at a MIC around 60 mcg/mL. 24Antiulcerogenic activity
Compounds active in the protective and curative effects on gastric ulcers may involve the fatty acids, β-carotene, α-tocopherol, and β-sitosterol found in sea buckthorn. Oral administration of CO 2 extracted seed and pulp oils from sea buckthorn may have protective and curative effects in water-immersion ( P < 0.05), reserpine-induced ( P < 0.01), pylorus ligation-induced ( P < 0.05), and acetic acid-induced gastric ulcers ( P < 0.01) in rats. 6 Effects on skin and mucosa have been associated with the sterols and long-chain alcohols in sea buckthorn.Animal data
The efficacy of a carbopol gel containing an extract of sea buckthorn was examined in experimental skin wounds in rats. Biopsy revealed that epithelization was more intensive, and occurred earlier, and granulation tissue differentiation (mature collagen fibers, profuse vascularity) was quicker in rats treated with the gel extract. 25Clinical data
One review article documents that topically applied sea buckthorn oil promotes healing of various wounds, burns, and irradiation dermatitis in skin. 4
Dietary supplementation with extracted seed and soft part (berry flesh and peel) sea buckthorn oil was tested on 49 atopic dermatitis patients in a double-blind, parallel, randomized, placebo-controlled trial. Patients took 5 g (10 capsules) of seed oil, pulp oil, or paraffin oil (control group) by mouth daily for 4 months. 26
Patients treated with the seed oil had increased levels of linoleic, α-linolenic, and eicosapentaenoic acids in plasma lipids. After 1 month of treatment, these patients reported improvement of atopic dermatitis symptoms, which correlated with an increase in α-linolenic acid in plasma lipids. The proposed mechanism of action for these positive effects was inhibition of the synthesis of the 4-series leukotrienes from arachidonic acid and an increased synthesis of the 5-series leukotrienes. Patients treated with the pulp oil had increased levels of palmitoleic acid ( P < 0.05) in plasma phospholipids and neutral lipids. However, the changes in palmitoleic acid did not correlate with symptom improvements. The pharmacological effects of the oils may be related to different mechanisms involving components other than fatty acids. No changes were detected in the levels of triacylgylcerols, serum total, and specific IgE. 26
Seed and pulp oil supplementation over 4 months did not lead to changes in the skin glycerophospholipids of 16 atopic dermatitis patients in a placebo-controlled, parallel, randomized, double-blind trial. 27Effects on liver injury
The seed oil inhibited malondialdehyde formation of liver induced by CCl 4 , ethyl alcohol, and acetaminophen in mice. It decreased serum glutamic pyruvic transaminase levels induced by CCl 4 and acetaminophen. Furthermore, the seed oil from sea buckthorn blocked the depletion of glutathione in acetaminophen-induced liver damage. Hepatoprotective properties of the oil have been demonstrated in rats. 28 , 29Clinical data
Clinical effects of the oil have been tested in 48 cirrhotic patients of Child-Pugh grade A and B treated with a sea buckthorn extract of 15 g by mouth 3 times daily for 6 months. Primary outcomes included measurements of cytokines and various blood parameters of liver fibrosis and liver function tests (eg, IL-6, TNFα, ALB, AST, ALT). Patients treated with sea buckthorn extract had reduced serum levels of laminin, hyaluronic acid, total bile acid, and collagen types III and IV. These results suggest that the seed oil of sea buckthorn may be useful for prevention and treatment of liver disease. 30Effects on platelet aggregation
In vitro and animal data
Total flavones from sea buckthorn fruit prolonged thrombotic occlusion time in a mouse femoral artery thrombosis model. In the same study, total flavones inhibited platelet aggregation induced by collagen in a concentration-dependent manner but did not affect aggregation induced by arachidonic acid and adenosine diphosphate. Mechanism of action remains unclear but may be caused by suppression of arachidonic acid synthesis by collagen receptor stimulation. 31Clinical data
The effects of sea buckthorn berry oil on cardiovascular (CV) disease risk was studied over a 4-week period in 12 healthy normolipidemic men in a double-blind, randomized, crossover study. Patients were treated with ten 500 mg capsules of sea buckthorn berry oil by mouth daily. Patients taking sea buckthorn berry oil indicated a clear decrease in the rate of adenosine-5-diphosphate-induced platelet aggregation ( P < 0.05) and maximum aggregation (aggregation percentage at 4 minutes, P < 0.01). The mechanisms behind these effects remain unclear. 32Effects on CV disease risk factors
One review article documents results from animal experiments as to how sea buckthorn oil decreases plasma total and low-density lipoprotein (LDL)-cholesterol levels, increases the level of high-density lipoprotein (HDL)-cholesterol, inhibits thrombus formation and atherosclerosis, and inhibits oxidation of LDL. 4 , 33Clinical data
The effects on sea buckthorn juice on risk factors for CV disease were studied for 8 weeks in 20 men in a double-blind, placebo-controlled trial. Patients consumed 300 mL sea buckthorn juice or placebo by mouth daily for 8 weeks. Although not statistically significant, sea buckthorn juice supplementation appeared to increase plasma HDL cholesterol and decrease the susceptibility of LDL to oxidation. 33
In a study of 88 patients, total flavones in sea buckthorn did not alter the sympathetic activity in treatment of hypertension when compared with patients being treated with nifedipine and extended-release verapamil. 34Antioxidant effects
In vitro and animal data
Numerous studies clearly demonstrate the antioxidant activity of sea buckthorn. The alcoholic leaf and fruit extracts of sea buckthorn inhibited chromium (VI)-induced free radicals, apoptosis, and deoxyribonucleic acid fragmentation. A hexane extract inhibited depletion of glutathione in gastric tissue and inhibited nicotine-induced oxidative damage in erythrocytes. Oil supplementation increased the activation of glutathione peroxidase, superoxide dismutase, glucose-6-phosphate dehydrase, and membrane levels of sialic acid and the sulfydryl group in erythrocytes. The oil also protects against oxidative damage from sulfur dioxide. 1 , 4 , 11 , 14 , 22 , 35 , 36Anticancer and radioprotective effects
In vitro and animal data
Protection against whole-body irradiation has been reported in mice; an alcoholic extract of the berries rendered nearly 82% survival as compared with no survival in untreated irradiated control. In liver, the oil from the berries inhibited the Fenton reaction and radiation-mediated generation of hydroxyl radicals, and superoxide anion mediated nitroblue tetrazolium reduction and FeSO 4 -mediated lipid peroxidation. The radioprotective effects may be associated with any of the following actions: free-radical scavenging, acceleration of stem cell proliferation, immunostimulation, and direct modulation of chromatin organization. 2 , 37 , 38
Flavonoids from oil extracted from the seeds of sea buckthorn induced apoptosis in the liver cancer cell line BEL-7402. In the human breast carcinoma cell line Bcap-37, 32 genes related to apoptosis were induced by flavonoids from seed extracts of sea buckthorn. Flavonols from sea buckthorn inhibited promyelotic leukemia HL-60 cells. Fruit and berry extracts from sea buckthorn inhibited the growth of colon cancer cells HT29 and breast cancer cells MCF-7 in a dose-dependent manner. These extracts inhibited carcinogen-induced forestomach and skin tumorigenesis in mice; mechanisms of action may involve up-regulation of phase II (eg, glutathione S-dimutase, catalase, glutathione peroxidase, glutathione reductase) and antioxidant enzymes. 13 , 39 , 40 , 41 , 42
Sea buckthorn oil may stimulate the recovery of hematopoiesis after chemotherapy. Blood cell counts in mice with myelosuppression fed with oil from sea buckthorn exceeded those in the control group and mortality decreased. 43Other pharmacological effects
Flavonoids from seed and fruit extracts of sea buckthorn inhibited glycometabolism and reduced serum glucose, serum cholesterol, and serum triglycerides in mice. The seed oil from sea buckthorn may reduce infarction volume after occlusion of middle cerebral artery in rats and protect against ischemic cerebral infarction. Sea buckthorn juice may protect against learning and memory changes caused by lead-induced neurotoxicity in mice. Flavones from sea buckthorn promoted healing of the patellar tendon in a rat model by enhancing collagen deposition and muscle fiber recovery. Administration of a sea buckthorn leaf extract on the same day or 5 days prior to inducing inflammation in the right hind paw of rats reduced the inflammation in a dose-dependent manner when compared with controls. 44 , 45 , 46 , 47 , 48
There is no clinical data on safety in pregnancy and lactation.
InteractionsCyclophosphamide and farmorubicin
Sea buckthorn oil decreased the cytogenetic action of cyclophosphamide and farmorubicin. 49Cisplatin
Sea buckthorn juice decreased the genotoxic effects of cisplatin on bone marrow and sperm cells in mice at a dose of 1.2 mg/kg. 50
None well documented.
One review article documents sea buckthorn's history of use as a food in Asia and in Europe. Research from toxicological studies using animal models suggests seed oil and oil from the fruit's soft parts are safe. These studies also examined acute and chronic toxicity of blood, liver, and heart as well as mutagenicity and teratogenicity of ingested oils. 4
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