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Ginkgo biloba

Scientific Name(s): Ginkgo biloba L.
Common Name(s): Ginkgo, Ginkyo, Kew tree, Maidenhair tree, Yinhsing (Japanese silver apricot)

Clinical Overview


Ginkgo has been studied extensively in diverse medical conditions. Findings from large trials have been pivotal in evaluating the efficacy of G. biloba extracts; however, there is not enough quality evidence to support the use of ginkgo for any indication. Evidence is lacking to support a protective role in cardiovascular conditions and stroke. Ginkgo's place in therapy for dementia seems limited, and a role in schizophrenia has not been established. Additionally, data do not support enhanced cognitive function resulting from G. biloba use in healthy individuals. Although interest exists in chemotherapeutic applications, safety concerns persist.


Standardized ginkgo leaf extracts have been used in clinical trials for cognitive and cardiovascular disorders at daily doses of 120 to 240 mg.


Contraindications have not been established.


Information regarding safety and efficacy in pregnancy and lactation is lacking. Ginkgo should be used with caution during pregnancy, particularly around labor due to risk of prolonged bleeding time, and should be avoided during lactation.


At recommended doses, standardized preparations of ginkgo leaf extract are unlikely to exhibit any clinically important interactions.

Adverse Reactions

Severe adverse reactions are rare; possible reactions include headache, dizziness, heart palpitations, and GI and dermatologic reactions. Ginkgo pollen can be strongly allergenic. Contact with the fleshy fruit pulp may cause allergic dermatitis similar to that caused by poison ivy.


Concerns persist regarding the safety of ginkgo leaf extract, based on studies in rodents that suggested increased mitosis and proliferation of tumor cells, as well as the large Ginkgo Evaluation of Memory (GEM) study in which the potential for an increased risk of certain cancers was noted. Consumption of the seeds may induce a toxic syndrome.


The dioecious ginkgo is the world's oldest living tree species. It has been traced back more than 200 million years to fossils of the Permian geologic period and is the sole survivor of the family Ginkgoaceae. Individual trees may live as long as 1,000 years and grow to a height of approximately 38 m. Ginkgo has characteristic fan-shaped leaves. Male trees older than 20 years blossom in the spring, and adult female trees produce plum-like, yellow-brown drupe that fall in late autumn. The fleshy layer and pulp have a foul, offensive odor and can cause contact dermatitis. The edible inner seed resembles an almond and is sold in Asian markets.USDA 2018, WHO 1999


The ginkgo species almost became extinct during the last ice age that began approximately 2 million years ago. The species survived in China, where it was cultivated as a sacred tree, and it still decorates Buddhist temples throughout Asia. Ginkgo preparations have been used for medicinal purposes for more than 1,000 years. Traditional Chinese physicians used ginkgo leaves to treat asthma and chilblains. Roasted ginkgo seeds were consumed in ancient China and Japan and were considered a digestive aid and preventive agent for drunkenness. In the Western world, ginkgo has been used since the 1960s, when technology made it possible to isolate its active compounds. The flavonoids act as free radical scavengers, and the terpenes (ginkgolides) inhibit platelet-activating factor. Ginkgo is one of the most commonly prescribed medications in Europe, but it is not approved for medical use in the United States, where it is sold only as a nutritional supplement.Mohanta 2014, WHO 1999


Reviews of the chemical constituents of ginkgo have been published. Analytical methods, biological standardization, and fingerprinting of ginkgo extracts have been reported.Liu 2015, Ude 2013, van Beek 2009

The main medicinal constituents of ginkgo are found in the leaf. These include flavonoids and several terpene trilactones unique to ginkgo (ginkgolides and bilobalide). The 3 major flavonoids of ginkgo are quercetin, kaempferol, and isorhamnetin. Approximately 40 minor flavonoids have also been identified, including catechins, dehydrocatechins (proanthocyanidins), and flavones (eg, ginkgetin, amentoflavone, bilobetin, sciadopitysin). The major terpene molecules unique to ginkgo are ginkgolides A, B, C, J, and M and bilobalide. Other medicinal constituents of ginkgo include shikimic, vanillic, ascorbic, and p-coumaric acids. Other leaf components include the steroids sitosterol and stigmasterol, polyprenols, benzoic acid derivatives, carbohydrates, straight chain hydrocarbons, alcohol, ketones, and 2-hexenol. There is seasonal variation in active compound content of the leaves, with the highest amounts present in autumn.Liu 2015, Ude 2013, van Beek 2009

The seed portion of ginkgo contains carbohydrate (38%), protein (4%), and less than 2% fat. Ginkgotoxin, amino acids, cyanogenetic glycosides, and long-chain phenols, including anacaric acid, bilobol, and cardanol, are also present. Ginkgolic acid and related alkylphenols from the lipid fraction of the fruit pods have been reviewed. The foul-smelling odor of the fleshy portion of the seedcoat is caused by high concentrations of butanoic and hexanoic acids. 4-O-methylpyridoxine has been isolated from the seeds.Liu 2015, Ude 2013, USDA 2018, van Beek 2009

Uses and Pharmacology


Animal and in vitro data

A standardized extract of G. biloba leaves has been examined in several forms of cancer, and numerous mechanisms of action have been proposed based on in vitro studies.Cao 2017, Eli 2006, Li 2002, Liu 2017, Lou 2017, Park 2017, Pretner 2006 Some animal experiments suggest that ginkgo leaf extract reduces the risk of oral cavity, stomach, and colorectal cancer.Ahmed 2017, Chen 2005, Kim 2005, Wang 2000 The deleterious effects of electromagnetic radiation on hippocampal cells were reduced by ginkgo extract given to rats for 1 month,Gevrek 2018 and a protective effect was reported in bleomycin-induced lung fibrosis in rats.Iraz 2006

Conversely, in a mouse colon cancer model, ginkgo exacerbated metastasis to the liver and decreased necrosis and apoptosis of tumor cells.Wang 2017 This is potentially explained by observed carcinogenicity of quercetin in rodents.Wang 2017

Clinical data

Limited clinical studies evaluating use of ginkgo in cancer have produced equivocal findings. Smaller clinical studies have generally reported positive findings,Bonassi 2018, Hauns 2001, Xu 2003 and one epidemiologic study claimed that ginkgolide A and B may be associated with chemoprevention of certain forms of ovarian cancer.Ye 2007 However, in an analysis of cancer as a secondary end point in the 3,069 participants of the GEM study, no protective effect of ginkgo was observed. For site-specific cancers, there were nonsignificant trends towards an increased risk of breast (hazard ratio [HR], 2.15; 95% CI, 0.97 to 4.8; P=0.06) and colorectal (HR, 1.62; 95% CI, 0.92 to 2.87; P=0.1) cancers, and a reduced risk of prostate cancer (HR, 0.71; 95% CI, 0.43 to 1.17; P=0.18).Biggs 2010

Antioxidant effects of G. biloba extract were studied in Chernobyl nuclear accident recovery workers with clastogenic factors evidenced as DNA fragmentation and damage. G. biloba extract was tested on the plasma of salvage personnel; after 2 months of treatment at 120 mg per day, plasma clastogenic factors regressed or completely disappeared.Eli 2006, Emerit 1995 An anticlastogenic effect was demonstrated for ginkgo versus placebo in patients with Graves disease who were receiving radioiodine therapy.Dardano 2007

Cardiovascular disease and stroke

Animal data

Animal studies report efficacy in preventing cardiovascular conditions, and researchers have attempted to explain the mechanisms by which the extract may act.Abdel-Zaher 2017, Jiang 2017, Li 2009, Tang 2017, Wu 2008 Antiplatelet activity has been described, although evidence from controlled studies consistently indicates that ginkgo does not significantly impact hemostasis.Bone 2008

Clinical data

Evidence is lacking to support a protective role in cardiovascular conditions and stroke.

The GEM study (N=3,069 elderly men and women) preplanned an evaluation of cardiovascular outcomes and found no evidence that ginkgo 240 mg/day reduced total or cardiovascular mortality or cardiovascular events.Kuller 2010 A statistically significant positive finding was obtained for ginkgo in peripheral vascular disease; however, the number of events was too small to make any generalizations.Kuller 2010 Similarly, ginkgo did not reduce blood pressure in hypertensive or normotensive participants in the GEM study.Brinkley 2010 A 2009 Cochrane meta-analysis of 14 clinical trials evaluating the role of ginkgo in intermittent claudication found no evidence of a clinically important benefit in patients with peripheral arterial disease; the 2013 update reinforced this conclusion.Nicolaï 2009, Nicolai 2013 The American College of Cardiology Foundation/American Heart Association guidelines for the management of peripheral artery disease (2005/2011) state that the effectiveness of ginkgo in improving walking distance for patients with intermittent claudication is marginal and not well established (level B evidence).Anderson 2013

A Cochrane systematic review of studies to 2005, including 10 trials (N=792) assessing the efficacy of ginkgo, found no convincing evidence to support the use of ginkgo for recovery after stroke or for improvement in neurological deficit at the end of treatment.Zeng 2005

In a double-blind, randomized, placebo-controlled trial (N=102), significantly more patients in the ginkgo group achieved a 50% reduction in 4-month poststroke follow-up National Institutes of Health Stroke Scale (NIHSS) score compared with baseline than those in the placebo group (58.6% vs 18.5%, respectively; P<0.05).Oskouei 2013 In contrast, multivariate regression analysis of the trend of NIHSS scores from admission to follow-up revealed a significant decline in scores for G. biloba when adjusted for age and gender (P<0.05).Oskouei 2013

CNS effects

The widespread use of G. biloba extracts in clinical trials makes data from animal studies largely redundant.

Clinical data

It remains unclear whether ginkgo has a role in reducing the incidence of dementia in elderly patients or protecting against decline in cognitive function.

Results of 2 large clinical trials have been published: the GEM study (N=3,069) and the GuidAge study (N=2,854). The GEM study found no effect of ginkgo in reducing the incidence of dementia or in preventing decline in cognitive impairment among enrolled older adult participants with normal to mild cognitive impairment.DeKosky 2008, Snitz 2009 Similarly, in the GuidAge study, long-term use of standardized ginkgo extract had no effect on the risk of progression to Alzheimer disease compared with placebo.Vellas 2012

In the Impact of Cholinergic Treatment Use (ICTUS) study (N=828), 96.5% of patients received cholinesterase inhibitor therapy alone and 3.5% received ginkgo in combination with cholinesterase inhibitors. Improvements in Mini Mental State Examination (MMSE) score were observed in the combination therapy group; however, changes in the Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog) subscale score and the Activities of Daily Living score were not significantly different. Patients receiving combination therapy were found to have a significantly higher education level (P=0.01) and lower baseline ADAS-Cog score (P<0.01) compared to those receiving cholinesterase inhibitor therapy alone.Canevelli 2014

In a retrospective study, outcomes were compared in 189 patients 80 years or older with Alzheimer disease who had used either donepezil or standardized G. biloba extract (EGb 761) for 12 months. No differences were noted in cognitive decline, as measured by MMSE. Rates of discontinuation because of lack of effect were similar between groups; however, more donepezil patients discontinued because of adverse effects.Rapp 2018

A Cochrane meta-analysis (published in 2009 and including 36 trials) found that results lacked consistent evidence of clinically important effects on dementia or cognitive impairment. Some trials included in the meta-analysis were of small sample size, and treatment duration was less than 3 months in each of the studies.Birks 2009

The effect of G. biloba on cognitive function in healthy individuals was examined in a systematic review and meta-analysis published in 2012, which concluded that no positive effect was evident for memory, executive function, or attention in 13 studies involving more than 2,500 participants.Laws 2012

Multiple other systematic reviews have been published, with many including subgroup analyses.Butler 2018, Cicero 2018 Clinical studies involving commercial industry generally report greater improvements in cognitive and neuropsychiatric measures.Gavrilova 2014, Ihl 2011, Napryeyenko 2007, Savaskan 2018, Von Gunten 2016, Yancheva 2009

A number of guidelines have been published on the use of ginkgo in Alzheimer disease and dementia. The European Federation of Neurological Sciences guidelines on the management of Alzheimer disease (2010) state that there is insufficient evidence to support the use of ginkgo for primary prevention of dementia, and that ginkgo should not be used in the treatment of patients with mild cognitive impairment. Additionally, the guidelines state that there is inconsistent evidence supporting the use of ginkgo in the treatment or prevention of Alzheimer disease.Hort 2010 According to a British Association for Psychopharmacology revised (third) consensus statement (2017), until further evidence is available, ginkgo cannot be recommended for either treatment or prevention of Alzheimer disease.O'Brien 2017

The American Academy of Neurology (AAN) practice parameter for the management of dementia (published in 2001, reaffirmed in 2003) states that some patients with unspecified dementia may benefit from G. biloba; however, evidence-based efficacy data are lacking (practice option recommendation).Doody 2001 The American Association for Geriatric Psychiatry position statement for patients with dementia resulting from Alzheimer disease (2006) does not recommend the general use of ginkgo for Alzheimer disease.Lyketsos 2006 The American Psychiatric Association practice guideline for the treatment of patients with Alzheimer disease and other dementias (2007) does not recommend ginkgo for routine use in treating cognitive and functional loss due to uncertainty regarding safety and efficacy.Rabins 2007

Ginkgo extracts have been studied in clinical trials for conditions including schizophrenia, attention-deficit/hyperactivity disorder (ADHD), dyslexia, autism, anxiety, and migraine, with varying results.D'Andrea 2009, Donfrancesco 2007, Lovera 2007, Niederhofer 2009, Savage 2018, Woelk 2007, Yancheva 2009

As an antioxidant, ginkgo is of interest in schizophrenia. Meta-analyses of quality clinical trials evaluating ginkgo as add-on therapy in chronic schizophrenia have been conducted; G. biloba extract performed better than placebo in the management of total and negative symptoms.Chen 2015, Magalhães 2016, Singh 2010 However, data from a systematic review of herbal and nutritional products for treatment of ADHD in 50 children suggested that ginkgo 80 to 120 mg/day for 6 weeks provided no benefit compared with methylphenidate.Sarris 2011

Guidelines have been published regarding ginkgo's use in major depressive disorder and tardive dyskinesia. AAN guidelines for the treatment of tardive syndromes, including tardive dyskinesia syndrome (2013), conclude that G. biloba extract is probably useful in treatment of tardive dyskinesia syndrome; however, data are limited to inpatients with schizophrenia.Bhidayasiri 2013 For major depressive disorder, the Canadian Network for Mood and Anxiety Treatments clinical guidelines for the management of major depressive disorder in adults (2009) state there is insufficient evidence to provide recommendations regarding use of gingko.Ravindran 2009

The AAN guideline on complementary and alternative medicine in multiple sclerosis (2014) advises that ginkgo is possibly effective for reducing short-term fatigue (low-quality evidence) and is ineffective for improving cognition (high-quality evidence).Yadav 2014


Clinical data

A limited number of small trials evaluating use of ginkgo in diabetes have been conducted. After 3-month ingestion of G. biloba extract in one study (N=20), significant (P<0.001) increases in fasting plasma levels of insulin and C-peptide, and in insulin and C-peptide area under the curve (AUC) were observed after a 2-hour 75 g oral glucose tolerance test. No changes in glucose tolerance were observed.Kudolo 2000 In a follow-up study of type 2 diabetes patients taking oral hypoglycemic agents, ginkgo increased pancreatic beta cell function in response to glucose loading.Kudolo 2001 Over a 3-month period, the pharmacokinetic properties of metformin 500 mg once daily were not affected by coadministration of 120 mg of ginkgo.Kudolo 2006 Ingestion of 120 mg/day of standardized ginkgo extract for 3 months did not produce insulin resistance in nondiabetic and prediabetic populations, nor did it exacerbate the disease in type 2 diabetic subjects.Aziz 2018, Kudolo 2006

Menopause/Sexual dysfunction

Clinical data

Evidence is lacking regarding the role of gingko in the management of menopausal symptoms or sexual function in women.Reid 2014, Wheatley 2004 Clinical trials with small sample sizes have produced varying and equivocal results regarding effects of ginkgo on sexual function.Ashton 2000, Boone 2005, Oh 2006, Ozgoli 2009, Wheatley 2004 In one study (N=99), G. biloba extract had a small but significant facilitatory effect on physiological, but not subjective, sexual arousal compared to placebo. The long-term effects of G. biloba extract on sexual function were then assessed in 68 sexually dysfunctional women randomly assigned to 8 weeks of treatment with G. biloba extract 300 mg/day, placebo, sex therapy alone, or sex therapy in combination with G. biloba extract. G. biloba extract was determined to be no more effective than placebo.Meston 2008 Canadian Society of Obstetricians and Gynaecologists revised clinical practice guidelines on managing menopause (2014) do not recommend ginkgo for reducing menopausal symptoms, based on a lack of evidence supporting clinical benefit.Reid 2014


Clinical data

Small studies suggest efficacy in treating migraine; however, methodological limitations (eg, open-label design, multi-ingredient preparations tested) do not allow for extrapolation of the findings.Allais 2013

Ophthalmologic effects

Animal data

Studies in rodents suggest that antioxidant and vascular effects of ginkgo may have a role in glaucomaHirooka 2004, Wimpissinger 2007 and cataractogenesis prevention.Khedr 2018

Clinical data

Limited clinical studies have reported positive findings with G. biloba use in patients with glaucoma.Harris 2018, Kang 2018, Ritch 2005


Animal data

In rats with induced osteoporosis given ginkgo for 30 days, bone mineral density was improved.Lucinda 2017

Dental effects

Animal data

Protective effects were observed in a study of rats with induced periodontitis administered G. biloba extract.Freires 2018


Publication of clinical trial data makes available animal studies of tinnitus less relevant, except to establish a mechanism of action.Dogan 2018, Esen 2018

Clinical data

A Cochrane meta-analysis of 4 clinical trials (N=1,543) conducted up to March 2012 in adults with tinnitus, either as the primary complaint or as a component of cerebral insufficiency, showed no evidence that supplemental ginkgo was effective. In patients with vascular dementia or Alzheimer disease and tinnitus, a small but statistically significant reduction in tinnitus was observed.Hilton 2013 A literature review reports equivocal results,Mahmoudian-Sani 2017 and a small (N=56) clinical study found no effect of ginkgo supplementation on idiopathic sudden sensorineural hearing loss for most outcomes measured, except for speech discrimination.Koo 2016

The American Association of Otolaryngology – Head and Neck Surgery clinical practice guidelines for tinnitus (2014) recommend against the use of ginkgo or other dietary supplements for treating patients with persistent tinnitus (moderate-quality aggregate evidence).Tunkel 2014

Other uses

Limited studies suggest potential applications in hyperuricemia,Zhang 2017 renoprotection,Chávez-Morales 2017, Zhang 2017 and aerobic performance.Sadowska-Krępa 2017

Ginkgo has been evaluated for the prevention of acute mountain sickness, with equivocal results.Leadbetter 2009, Moraga 2007


Standardized ginkgo leaf extracts such as EGb 761 have been used in clinical trials for cognitive and cardiovascular disorders at daily doses of 120 to 240 mg.DeKosky 2008, Kuller 2010, Snitz 2009 Extracts are usually standardized to 24% flavones and 6% terpene lactones.DeKosky 2008, Snitz 2009 Ginkgo is commercially available in several doseforms, including teas, liquids, colas, capsules, extracts, tablets, sprays, and bars.

Pharmacokinetic testing of ginkgo doseforms, including capsules, drops, and tablets, has been conducted. When ginkgo is administered orally during fasting, bioavailability is high; food did not change the AUC quantitatively but did increase the time to maximum plasma concentration.Ude 2013, Woelkart 2010

The availability of unregulated or nonstandardized products needs to be considered when using ginkgo.Yadav 2014

Pregnancy / Lactation

Although a systematic review reports that traditional and common use has not indicated substantive risks in pregnancy or lactation, very weak scientific evidence from animal and in vitro studies shows ginkgo leaf has antiplatelet activity, and low-level evidence based on expert opinion shows ginkgo leaf may be an emmenagogue. Ginkgo should be used with caution during pregnancy, particularly around labor due to risk of prolonged bleeding time, and should be avoided during lactation.Dugoua 2006 An animal study of pregnant rats treated with ginkgo 7 to 14 mg/kg/day reported reduced fetal body weights,Pinto 2007 while another study found no evidence of embryotoxicity.Fernandes 2010


At recommended doses, standardized preparations of ginkgo leaf extract are unlikely to exhibit any clinically important interactions.Bone 2008, Unger 2013 Caution may be required with use of raw extracts of the leaf with anticoagulants, although evidence from controlled studies consistently indicates that ginkgo does not impact hemostasis.Bone 2008

At higher than recommended dose levels, weak induction of cytochrome P450 (CYP-450) 2C19- and weak inhibition of CYP3A4-mediated metabolism has been observed, as well as a limited effect on drug transporters.Unger 2013 Case reports of treatment failure implicate ginkgo, including in a 41-year-old man receiving antiretroviral therapy with efavirenz and taking a G. biloba 300 mg/day supplementNaccarato 2012; other studies suggest no interaction with raltegravir.Blonk 2012

The availability of unregulated or nonstandardized products, as well as potential interactions of supplements with pharmaceutical medications, must be considered when using ginkgo.Yadav 2014

Adverse Reactions

In large clinical trials using maximum dosages of standardized ginkgo extract 240 mg/day for durations of up to 6 years, reported adverse reactions did not differ from those in placebo groups.Birks 2009, Dekosky 2008, Snitz 2009, Weinmann 2010 A trial evaluating the safety and effectiveness of ginkgo at dosages of 240 mg/day over 22 weeks found no difference in adverse events for ginkgo compared with placebo.Napryeyenko 2009

The effect of ginkgo on platelets is unclear, but evidence from controlled studies consistently indicates that ginkgo does not impact hemostasis.Bone 2008 Case reports of increased bleeding risk exist, but clinical trials have found no effect on platelet function.Bebbington 2005, Rosenblatt 1997, Wolf 2006 Ginkgo should be used with caution in populations with bleeding risks.Page 2016

Severe adverse reactions are rare. Case reports describe headache, dizziness, and heart palpitations, as well as GI and dermatologic reactions. Injectable forms of ginkgo may cause circulatory disturbances, skin allergy, or phlebitis; parenteral ginkgo was withdrawn from the market because of the potential for severe adverse reactions.De Smet 1997 Ginkgo products have been implicated in reports of hepatic injury collected between 2004 and 2013 by 8 US centers in the Drug-induced Liver Injury Network.Navarro 2014 Ginkgo pollen can be strongly allergenic. Contact with the fleshy drupe pulp can cause allergic dermatitis similar to that caused by poison ivy.De Smet 1997 Case reports of seizures associated with ginkgo supplementation existGranger 2001; however, ginkgo extracts have been shown to exhibit both anti- and proconvulsant activity in animal experiments.Jahanshahi 2012, Lee 2012


Data have been reported regarding the carcinogenic potential of G. biloba extract, with increased mitosis and cell proliferation observed in some,Wang 2017 but not all, rodent studies.Fernandes 2010, Grollino 2017

Limited clinical studies have also produced equivocal findings. One study (N=47) reported no increase in liver injury markers or genomic measures (micronucleus frequency, comet assay, c-myc, p53, and ctnnb1 expression profile in lymphocytes).Bonassi 2018 In an analysis of cancer as a secondary end point in the 3,069 participants of the GEM study, no protective effect of ginkgo was observed. For site-specific cancers, there were nonsignificant trends towards an increased risk of breast (HR, 2.15; 95% CI, 0.97 to 4.8; P=0.06) and colorectal (HR, 1.62; 95% CI, 0.92 to 2.87; P=0.1) cancers, and a reduced risk of prostate cancer (HR, 0.71; 95% CI, 0.43 to 1.17; P=0.18).Biggs 2010

Ginkgo seeds have been reported to induce a toxic syndrome ("Gin-nan" food poisoning). Consumption of approximately 50 ginkgo seeds has produced convulsions in a 21-month-old child, and consumption of 70 to 80 seeds induced tonic-clonic seizures and loss of consciousness in a 36-year-old woman.Benjamin 2001, Hasegawa 2006, Miwa 2001 Between 1930 and 1960, 70 reports of poisoning related to ginkgo ingestion revealed a 27% mortality rate, with infants being the most vulnerable. Ginkgotoxin (4-O-methylpyridoxine), found only in the seeds, was considered responsible for this toxicity.De Smet 1997, Newall 1996


Abdel-Zaher AO, Farghaly HSM, El-Refaiy AEM, Abd-Eldayem AM. Protective effect of the standardized extract of Ginkgo biloba (EGb761) against hypertension with hypercholesterolemia-induced renal injury in rats: Insights in the underlying mechanisms. Biomed Pharmacother. 2017;95:944-955.28915536
Ahmed HH, El-Abhar HS, Hassanin EAK, Abdelkader NF, Shalaby MB. Ginkgo biloba L. leaf extract offers multiple mechanisms in bridling N-methylnitrosourea - mediated experimental colorectal cancer. Biomed Pharmacother. 2017;95:387-393.28858737
Allais G, D'Andrea G, Maggio M, Benedetto C. The efficacy of ginkgolide B in the acute treatment of migraine aura: an open preliminary trial. Neurol Sci. 2013;34(suppl 1):S161-S163.23695070
Anderson JL, Halperin JL, Albert NM, et al. Management of patients with peripheral artery disease (compilation of 2005 and 2011 ACCF/AHA guideline recommendations): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2013;127(13):1425-1243.23457117
Ashton AK, Ahrens K, Gupta S, Masand PS. Antidepressant-induced sexual dysfunction and Ginkgo Biloba. Am J Psychiatry. 2000;157(5):836-837.10784488
Aziz TA, Hussain SA, Mahwi TO, Ahmed ZA, Rahman HS, Rasedee A. The efficacy and safety of Ginkgo biloba extract as an adjuvant in type 2 diabetes mellitus patients ineffectively managed with metformin: a double-blind, randomized, placebo-controlled trial. Drug Des Devel Ther. 2018;12:735-742.29670330
Bebbington A, Kulkarni R, Roberts P. Ginkgo biloba: persistent bleeding after total hip arthroplasty caused by herbal self-medication. J Arthroplasty. 2005;20(1):125-126.15660071
Benjamin J, Muir T, Briggs K, Pentland B. A case of cerebral haemorrhage-can Ginkgo biloba be implicated? Postgrad Med J. 2001;77(904):112-113.11161079
Bhidayasiri R, Fahn S, Weiner WJ, Gronseth GS, Sullivan KL, Zesiewicz TA; American Academy of Neurology. Evidence-based guideline: treatment of tardive syndromes: report of the Guideline Development Subcommittee of the American Academy of Neurology [published correction appears in Neurology. 2013;81(22):1968]. Neurology. 2013;81(5):463-469.23897874
Biggs ML, Sorkin BC, Nahin RL, Kuller LH, Fitzpatrick AL. Ginkgo biloba and risk of cancer: secondary analysis of the Ginkgo Evaluation of Memory (GEM) Study. Pharmacoepidemiol Drug Saf. 2010;19(7):694-698.20582906
Birks J, Grimley Evans J. Ginkgo biloba for cognitive impairment and dementia. Cochrane Database Syst Rev. 2009;(1):CD003120.19160216
Blonk M, Colbers A, Poirters A, Schouwenberg B, Burger D. Effect of Ginkgo biloba on the pharmacokinetics of raltegravir in healthy volunteers. Antimicrob Agents Chemother. 2012;56(10):5070-5075.22802250
Bonassi S, Prinzi G, Lamonaca P, et al. Clinical and genomic safety of treatment with Ginkgo biloba L. leaf extract (IDN 5933/Ginkgoselect Plus) in elderly: a randomised placebo-controlled clinical trial [GiBiEx]. BMC Complement Altern Med. 2018;18(1):22.29357859
Bone KM. Potential interaction of Ginkgo biloba leaf with antiplatelet or anticoagulant drugs: what is the evidence? Mol Nutr Food Res. 2008;52(7):764-771.18214851
Boone SA, Shields KM. Dietary supplements for female sexual dysfunction. Am J Health Syst Pharm. 2005;62(6):574-580.15757877
Brinkley TE, Lovato JF, Arnold AM, et al; Ginkgo Evaluation of Memory (GEM) Study Investigators. Effect of Ginkgo biloba on blood pressure and incidence of hypertension in elderly men and women. Am J Hypertens. 2010;23(5):528-533.20168306
Butler M, Nelson VA, Davila H, et al. Over-the-Counter Supplement Interventions to Prevent Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer-Type Dementia: A Systematic Review. Ann Intern Med. 2018;168(1):52-62.2925590910.7326/M17-1530
Canevelli M, Adali N, Kelaiditi E, Cantet C, Ousset PJ, Cesari M; ICTUS/DSA Group. Effects of Ginkgo biloba supplementation in Alzheimer's disease patients receiving cholinesterase inhibitors: data from the ICTUS study. Phytomedicine. 2014;21(6):888-892.24548724
Cao C, Han D, Su Y, Ge Y, Chen H, Xu A. Ginkgo biloba exocarp extracts induces autophagy in Lewis lung cancer cells involving AMPK / mTOR / p70S6k signalling pathway. Biomed Pharmacother. 2017;93:1128-1135.2873852110.1016/j.biopha.2017.07.036
Chávez-Morales RM, Jaramillo-Juárez F, Rodríguez-Vázquez ML, Martínez-Saldaña MC, Del Río FAP, Garfias-López JA. The Ginkgo biloba extract (GbE) protects the kidney from damage produced by a single and low dose of carbon tetrachloride in adult male rats. Exp Toxicol Pathol. 2017;69(7):430-434.2841614510.1016/j.etp.2017.04.003
Chen SH, Liang YC, Chao JC, et al. Protective effects of Ginkgo biloba extract on the ethanol-induced gastric ulcer in rats. World J Gastroenterol. 2005;11(24):3746-3750.15968732
Chen X, Hong Y, Zheng P. Efficacy and safety of extract of Ginkgo biloba as an adjunct therapy in chronic schizophrenia: a systematic review of randomized, double-blind, placebo-controlled studies with meta-analysis. Psychiatry Res. 2015;228(1):121-127.25980333
Cicero AFG, Fogacci F, Banach M. Botanicals and phytochemicals active on cognitive decline: The clinical evidence [published online ahead of print December 28, 2017]. Pharmacol Res. 2018;130:204-212.2928957610.1016/j.phrs.2017.12.029
D'Andrea G, Bussone G, Allais G, et al. Efficacy of Ginkgolide B in the prophylaxis of migraine with aura. Neurol Sci. 2009;30(suppl 1):S121-S124.19415441
Dardano A, Ballardin M, Ferdeghini M, et al. Anticlastogenic effect of Ginkgo biloba extract in Graves' disease patients receiving radioiodine therapy. J Clin Endocrinol Metab. 2007;92(11):4286-4289.17711926
De Smet PA, ed. Adverse Effects of Herbal Drugs. New York, NY: Springer-Verlag; 1997:51-66.
DeKosky ST, Williamson JD, Fitzpatrick AL, et al; Ginkgo Evaluation of Memory (GEM) Study Investigators. Ginkgo biloba for prevention of dementia: a randomized controlled trial [published correction appears in JAMA. 2008;300(23):2730]. JAMA. 2008;300(19):2253-2262.19017911
Dogan R, Sjostrand AP, Yenıgun A, Karatas E, Kocyigit A, Ozturan O. Influence of Ginkgo biloba extract (EGb 761) on expression of IL-1 Beta, IL-6, TNF-alfa, HSP-70, HSF-1 and COX-2 after noise exposure in the rat cochlea. Auris Nasus Larynx. 2018;45(4):680-685.2904207110.1016/j.anl.2017.09.015
Donfrancesco R, Ferrante L. Ginkgo biloba in dyslexia: a pilot study. Phytomedicine. 2007;14(6):367-370.17517502
Doody RS, Stevens JC, Beck C, et al. Practice parameter: management of dementia (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2001;56(9):1154-1166.11342679
Dugoua JJ, Mills E, Perri D, Koren G. Safety and efficacy of ginkgo (Ginkgo biloba) during pregnancy and lactation. Can J Clin Pharmacol. 2006;13(3):e277-e284.17085776
Eli R, Fasciano JA. An adjunctive preventive treatment for cancer: ultraviolet light and Ginkgo biloba, together with other antioxidants, are a safe and powerful, but largely ignored, treatment option for the prevention of cancer. Med Hypotheses. 2006;66(6):1152-1156.16483725
Emerit I, Oganesian N, Sarkisian T, et al. Clastogenic factors in the plasma of Chernobyl accident recovery workers: anticlastogenic effect of Ginkgo biloba extract. Radiat Res. 1995;144(2):198-205.7480646
Esen E, Özdoğan F, Gürgen SG, et al. Ginkgo biloba and lycopene are effective on cisplatin induced ototoxicity? J Int Adv Otol. 2018;14(1):22-26.2863955510.5152/iao.2017.3137
Fernandes ES, Pinto RM, de Paula Reis JE, de Oliveira Guerra M, Peters VM. Effects of Ginkgo biloba extract on the embryo-fetal development in Wistar rats. Birth Defects Res B Dev Reprod Toxicol. 2010;89(2):133-138.20437472
Folium Ginkgo. In: WHO Monographs on Selected Medicinal Plants. Vol 1. Geneva, Switzerland: World Health Organization; 1999. Accessed June 26, 2018.
Freires IA, Santaella GM, de Cássia Orlandi Sardi J, Rosalen PL. The alveolar bone protective effects of natural products: A systematic review. Arch Oral Biol. 2018;87:196-203.2930677710.1016/j.archoralbio.2017.12.019
Gavrilova SI, Preuss UW, Wong JW, Hoerr R, Kaschel R, Bachinskaya N; GIMCIPlus Study Group. Efficacy and safety of Ginkgo biloba extract EGb 761 in mild cognitive impairment with neuropsychiatric symptoms: a randomized, placebo-controlled, double-blind, multi-center trial. Int J Geriatr Psychiatry. 2014;29(10):1087-1095.24633934
Gevrek F. Histopathological, immunohistochemical, and stereological analysis of the effect of Ginkgo biloba (Egb761) on the hippocampus of rats exposed to long-term cellphone radiation. Histol Histopathol. 2018;33(5):463-473.2912003110.14670/HH-11-943
Ginkgo biloba L. USDA, NRCS. 2018. The PLANTS Database (, February 2018). National Plant Data Team, Greensboro, NC 27401-4901 USA. Accessed February 2018.
Granger AS. Ginkgo biloba precipitating epileptic seizures. Age Ageing. 2001;30(6):523-525.11742783
Grollino MG, Raschellà G, Cordelli E, et al. Cytotoxicity, genotoxicity and gene expression changes elicited by exposure of human hepatic cells to Ginkgo biloba leaf extract. Food Chem Toxicol. 2017;109(pt 1):486-496.2894338710.1016/j.fct.2017.09.042
Harris A, Gross J, Moore N, et al. The effects of antioxidants on ocular blood flow in patients with glaucoma. Acta Ophthalmol. 2018;96(2):e237-e241.2877200510.1111/aos.13530
Hasegawa S, Oda Y, Ichiyama T, Hori Y, Furukawa S. Ginkgo nut intoxication in a 2-year-old male. Pediatr Neurol. 2006;35(4):275-276.16996402
Hauns B, Häring B, Köhler S, Mross K, Unger C. Phase II study of combined 5-fluorouracil/Ginkgo biloba extract (GBE 761 ONC) therapy in 5-fluorouracil pretreated patients with advanced colorectal cancer. Phytother Res. 2001;15(1):34-38.11180520
Hilton MP, Zimmermann EF, Hunt WT. Ginkgo biloba for tinnitus. Cochrane Database Syst Rev. 2013;(3):CD003852.23543524
Hirooka K, Tokuda M, Miyamoto O, Itano T, Baba T, Shiraga F. The Ginkgo biloba extract (EGb 761) provides a neuroprotective effect on retinal ganglion cells in a rat model of chronic glaucoma. Curr Eye Res. 2004;28(3):153-157.14977516
Hort J, O'Brien JT, Gainotti G, et al; EFNS Scientist Panel on Dementia. EFNS guidelines for the diagnosis and management of Alzheimer's disease. Eur J Neurol. 2010;17(10):1236-1248.20831773
Ihl R, Bachinskaya N, Korczyn AD, et al; GOTADAY Study Group. Efficacy and safety of a once-daily formulation of Ginkgo biloba extract EGb 761 in dementia with neuropsychiatric features: a randomized controlled trial. Int J Geriatr Psychiatry. 2011;26(11):1186-1194.21140383
Iraz M, Erdogan H, Kotuk M, et al. Ginkgo biloba inhibits bleomycin-induced lung fibrosis in rats. Pharmacol Res. 2006;53(3):310-316.16459098
Jahanshahi M, Nikmahzar E, Yadollahi N, Ramazani K. Protective effects of Ginkgo biloba extract (EGB 761) on astrocytes of rat hippocampus after exposure with scopolamine. Anat Cell Biol. 2012;45(2):92-96.22822463
Jiang H, Qu P. Effects of Ginkgo biloba leaf extract on local renin-angiotensin system through TLR4/NF-κB pathway in cardiac myocyte. Exp Ther Med. 2017;14(6):5857-5862.2928513310.3892/etm.2017.5313
Kang JM, Lin S. Ginkgo biloba and its potential role in glaucoma. Curr Opin Ophthalmol. 2018;29(2):116-120.2920665310.1097/ICU.0000000000000459
Khedr MH, Shafaa MW, Abdel-Ghaffar A, Saleh A. Radioprotective efficacy of Ginkgo biloba and Angelica archangelica extract against technetium-99m-sestamibi induced oxidative stress and lens injury in rats. Int J Radiat Biol. 2018;94(1):37-44.29157082
Kim KS, Rhee KH, Yoon JH, Lee JG, Lee JH, Yoo JB. Ginkgo biloba extract (EGb 761) induces apoptosis by the activation of caspase-3 in oral cavity cancer cells. Oral Oncol. 2005;41(4):383-389.15792610
Koo JW, Chang, MY, Yun SC, et al. The efficacy and safety of systemic injection of Ginkgo biloba extract, EGb761, in idiopathic sudden sensorineural hearing loss: a randomized placebo-controlled clinical trial. Eur Arch Otorhinolaryngol. 2016;273(9):2433-2441.26559533
Kudolo GB. The effect of 3-month ingestion of Ginkgo biloba extract on pancreatic beta-cell function in response to glucose loading in normal glucose tolerant individuals. J Clin Pharmacol. 2000;40(6):647-654.10868316
Kudolo GB. The effect of 3-month ingestion of Ginkgo biloba extract (EGb 761) on pancreatic beta-cell function in response to glucose loading in individuals with non-insulin-dependent diabetes mellitus. J Clin Pharmacol. 2001;41(6):600-611.11402628
Kudolo GB, Wang W, Elrod R, Barrientos J, Haase A, Blodgett J. Short-term ingestion of Ginkgo biloba extract does not alter whole body insulin sensitivity in non-diabetic, pre-diabetic or type 2 diabetic subjects—a randomized double-blind placebo-controlled crossover study. Clin Nutr. 2006;25(1):123-134.16293352
Kudolo GB, Wang W, Javors M, Blodgett J. The effect of the ingestion of Ginkgo biloba extract (EGb 761) on the pharmacokinetics of metformin in non-diabetic and type 2 diabetic subjects—a double blind placebo-controlled, crossover study. Clin Nutr. 2006;25(4):606-616.16698134
Kuller LH, Ives DG, Fitzpatrick AL, et al; Ginkgo Evaluation of Memory Study Investigators. Does Ginkgo biloba reduce the risk of cardiovascular events? Circ Cardiovasc Qual Outcomes. 2010;3(1):41-47.20123670
Laws KR, Sweetnam H, Kondel TK. Is Ginkgo biloba a cognitive enhancer in healthy individuals? A meta-analysis. Hum Psychopharmacol. 2012;27(6):527-533.23001963
Leadbetter G, Keyes LE, Maakestad KM, Olson S, Tissot van Patot MC, Hackett PH. Ginkgo biloba does—and does not—prevent acute mountain sickness. Wilderness Environ Med. 2009;20(1):66-71.19364166
Lee GH, Sung SY, Chang WN, et al. Zebrafish larvae exposed to ginkgotoxin exhibit seizure-like behavior that is relieved by pyridoxal-5′-phosphate, GABA and anti-epileptic drugs. Dis Model Mech. 2012;5(6):785-795.22736461
Li W, Pretner E, Shen L, Drieu K, Papadopoulos V. Common gene targets of Ginkgo biloba extract (EGb 761) in human tumor cells: relation to cell growth. Cell Mol Biol (Noisy-le-grand). 2002;48(6):655-662.12396076
Li XS, Zheng WY, Lou SX, Lu XW, Ye SH. Effect of Ginkgo leaf extract on vascular endothelial function in patients with early stage diabetic nephropathy. Chin J Integr Med. 2009;15(1):26-29.19271166
Liu XG, Wu SQ, Li P, Yang H. Advancement in the chemical analysis and quality control of flavonoid in Ginkgo biloba. J Pharm Biomed Anal. 2015;113:212-225.25812435
Liu T, Zhang J, Chai Z, Wang G, Cui N, Zhou B. Ginkgo biloba extract EGb 761-induced upregulation of LincRNA-p21 inhibits colorectal cancer metastasis by associating with EZH2. Oncotarget. 2017;8(53):91614-91627.29207671
Lou JS, Bi WC, Chan GKL, et al. Ginkgetin induces autophagic cell death through p62/SQSTM1-mediated autolysosome formation and redox setting in non-small cell lung cancer. Oncotarget. 2017;8(54):93131-93148.29190983
Lovera J, Bagert B, Smoot K, et al. Ginkgo biloba for the improvement of cognitive performance in multiple sclerosis: a randomized, placebo-controlled trial. Mult Scler. 2007;13(3):376-385.17439907
Lucinda LMF, Aarestrup BJV, Reboredo MM, et al. Evaluation of the anti-osteoporotic effect of Ginkgo biloba L. in Wistar rats with glucocorticoid-induced-osteoporosis by bone densitometry using dual-energy x-ray absorptiometry (DEXA) and mechanical testing. An Acad Bras Cienc. 2017;89(4):2833-2841.29044313
Lyketsos CG, Colenda CC, Beck C, et al; Task Force of American Association for Geriatric Psychiatry. Position statement of the American Association for Geriatric Psychiatry regarding principles of care for patients with dementia resulting from Alzheimer disease [published correction appears in Am J Geriatr Psychiatry. 2006;14(9):808]. Am J Geriatr Psychiatry. 2006;14(7):561-572.16816009
Magalhães PV, Dean O, Andreazza AC, Berk M, Kapczinski F. Antioxidant treatments for schizophrenia. Cochrane Database Syst Rev. 2016;2:CD008919.2684892610.1002/14651858.CD008919.pub2
Mahmoudian-Sani MR, Hashemzadeh-Chaleshtori M, Asadi-Samani M, Yang Q. Ginkgo biloba in the treatment of tinnitus: An updated literature review. Int Tinnitus J. 2017;21(1):58-62.28723603
Meston CM, Rellini AH, Telch MJ. Short- and long-term effects of Ginkgo biloba extract on sexual dysfunction in women. Arch Sex Behav. 2008;37(4):530-547.18274887
Miwa H, Iijima M, Tanaka S, Mizuno Y. Generalized convulsions after consuming a large amount of gingko nuts. Epilepsia. 2001;42(2):280-281.11240603
Mohanta TK, Tamboli Y, Zubaidha PK. Phytochemical and medicinal importance of Ginkgo biloba L. Nat Prod Res. 2014;28(10):746-752.24499319
Moraga FA, Flores A, Serra J, Esnaola C, Barriento C. Ginkgo biloba decreases acute mountain sickness in people ascending to high altitude at Ollagüe (3696 m) in northern Chile [published correction appears in Wilderness Environ Med. 2008;19(1):51]. Wilderness Environ Med. 2007;18(4):251-257.18076292
Naccarato M, Yoong D, Gough K. A potential drug-herbal interaction between Ginkgo biloba and efavirenz. J Int Assoc Physicians AIDS Care (Chic). 2012;11(2):98-100.22323244
Napryeyenko O, Borzenko I; GINDEM-NP Study Group. Ginkgo biloba special extract in dementia with neuropsychiatric features. A randomised, placebo-controlled, double-blind clinical trial. Arzneimittelforschung. 2007;57(1):4-11.17341003
Napryeyenko O, Sonnik G, Tartakovsky I. Efficacy and tolerability of Ginkgo biloba extract EGb 761 by type of dementia: analyses of a randomised controlled trial. J Neurol Sci. 2009;283(1-2):224-229.19286192
Navarro VJ, Barnhart H, Bonkovsky HL, et al. Liver injury from herbals and dietary supplements in the U.S. Drug-Induced Liver Injury Network. Hepatology. 2014;60(4):1399-1408.25043597
Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-Care Professionals. London, England: Pharmaceutical Press; 1996:138-140.
Nicolaï SP, Kruidenier LM, Bendermacher BL, Prins MH, Teijink JA. Ginkgo biloba for intermittent claudication. Cochrane Database Syst Rev. 2009;(2):CD006888.19370657
Nicolai SP, Kruidenier LM, Bendermacher BL, et al. Ginkgo biloba for intermittent claudication. Cochrane Database Syst Rev. 2013;(6):CD006888.23744597
Niederhofer H. First preliminary results of an observation of Ginkgo Biloba treating patients with autistic disorder. Phytother Res. 2009;23(11):1645-1646.19274699
O'Brien JT, Holmes C, Jones M, et al. Clinical practice with anti-dementia drugs: A revised (third) consensus statement from the British Association for Psychopharmacology. J Psychopharmacol. 2017;31(2):147-168.28103749
Oh SM, Chung KH. Antiestrogenic activities of Ginkgo biloba extracts. J Steroid Biochem Mol Biol. 2006;100(4-5):167-176.16842996
Oskouei DS, Rikhtegar R, Hashemilar M, et al. The effect of Ginkgo biloba on functional outcome of paitents with acute ischemic stroke: a double-blind, placebo-controlled, randomized clinical trial. J Stroke Cerebrovasc Dis. 2013;22(8):e557-e563.23871729
Ozgoli G, Selselei EA, Mojab F, Majd HA. A randomized, placebo-controlled trial of Ginkgo biloba L. in treatment of premenstrual syndrome. J Altern Complement Med. 2009;15(8):845-851.19678774
Page RL 2nd, O'Bryant CL, Cheng D, et al; American Heart Association Clinical Pharmacology and Heart Failure and Transplantation Committees of the Council on Clinical Cardiology; Council on Cardiovascular Surgery and Anesthesia; Council on Cardiovascular and Stroke Nursing; and Council on Quality of Care and Outcomes Research. Drugs that may cause or exacerbate heart failure: a scientific statement from the American Heart Association [published correction appears in Circulation. 2016;134(12):e261]. Circulation. 2016;134(6):e32-e69.27400984
Park Y, Woo SH, Seo SK, et al. Ginkgetin induces cell death in breast cancer cells via downregulation of the estrogen receptor. Oncol Lett. 2017;14(4):5027-5033.29085516
Pinto RM, Fernandes ES, Reis JE, Peters VM, Guerra Mde O. Intra-uterine growth retardation after prenatal administration of Ginkgo biloba to rats. Reprod Toxicol. 2007;23(4):480-485.17287108
Pretner E, Amri H, Li W, et al. Cancer-related overexpression of the peripheral-type benzodiazepine receptor and cytostatic anticancer effects of Ginkgo biloba extract (EGb 761). Anticancer Res. 2006;26(1A):9-22.16475673
Rabins PV, Blacker D, Rovner BW, et al; APA Work Group on Alzheimer's Disease and other Dementias; Steering Committee on Practice Guidelines. American Psychiatric Association practice guideline for the treatment of patients with Alzheimer's disease and other dementias. Second edition. Am J Psychiatry. 2007;164(12)(suppl):5-56.18340692
Rapp M, Burkart M, Kohlmann T, Bohlken J. Similar treatment outcomes with Ginkgo biloba extract EGb 761 and donepezil in Alzheimer's dementia in very old age: A retrospective observational study. Int J Clin Pharmacol Ther. 2018;56(3):130-133.29319499
Ravindran AV, Lam RW, Filteau MJ, et al; Canadian Network for Mood and Anxiety Treatments (CANMAT). Canadian Network for Mood and Anxiety Treatments (CANMAT) Clinical guidelines for the management of major depressive disorder in adults. V. Complementary and alternative medicine treatments. J Affect Disord. 2009;117(suppl 1):S54-S64.19666194
Reid R, Abramson BL, Blake J, et al; Menopause and Osteoporosis Working Group. Managing Menopause. J Obstet Gynaecol Can. 2014;36(9):830-833.25222364
Ritch R. Complementary therapy for the treatment of glaucoma: a perspective. Ophthalmol Clin North Am. 2005;18(4):597-609.16314222
Rosenblatt M, Mindel J. Spontaneous hyphema associated with ingestion of Ginkgo biloba extract. N Engl J Med. 1997;336(15):1108.9091822
Sadowska-Krępa E, Kłapcińska B, Pokora I, Domaszewski P, Kempa K, Podgórski T. Effects of Six-Week Ginkgo biloba supplementation on aerobic performance, blood pro/antioxidant balance, and serum brain-derived neurotrophic factor in physically active men. Nutrients. 2017;9(8).28933745
Sarris J, Kean J, Schweitzer I, Lake J. Complementary medicines (herbal and nutritional products) in the treatment of attention deficit hyperactivity disorder (ADHD): a systematic review of the evidence. Complement Ther Med. 2011;19(4):216-227.21827936
Savage K, Firth J, Stough C, Sarris J. GABA-modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence. Phytother Res. 2018;32(1):3-18.29168225
Savaskan E, Mueller H, Hoerr R, von Gunten A, Gauthier S. Treatment effects of Ginkgo biloba extract EGb 761 on the spectrum of behavioral and psychological symptoms of dementia: meta-analysis of randomized controlled trials. Int Psychogeriatr. 2018;30(3):285-293.2893144410.1017/S1041610217001892
Singh V, Singh SP, Chan K. Review and meta-analysis of usage of ginkgo as an adjunct therapy in chronic schizophrenia. Int J Neuropsychopharmacol. 2010;13(2):257-271.19775502
Snitz BE, O'Meara ES, Carlson MC, et al; Ginkgo Evaluation of Memory (GEM) Study Investigators. Ginkgo biloba for preventing cognitive decline in older adults: a randomized trial. JAMA. 2009;302(24):2663-2670.20040554
Tang Y, Zhou G, Yao L, et al. Protective effect of Ginkgo biloba leaves extract, EGb761, on myocardium injury in ischemia reperfusion rats via regulation of TLR-4/NF-κB signaling pathway. Oncotarget. 2017;8(49):86671-86680.29156826
Tunkel DE, Bauer CA, Sun GH, et al. Clinical practice guideline: tinnitus. Otolaryngol Head Neck Surg. 2014;151(2)(suppl):S1-S40.25273878
Ude C, Schubert-Zsilavecz M, Wurglics M. Ginkgo biloba extracts: a review of the pharmacokinetics of the active ingredients. Clin Pharmacokinet. 2013;52(9):727-749.23703577
Unger M. Pharmacokinetic drug interactions involving Ginkgo biloba. Drug Metab Rev. 2013;45(3):353-385.23865865
van Beek TA, Montoro P. Chemical analysis and quality control of Ginkgo biloba leaves, extracts, and phytopharmaceuticals. J Chromatogr A. 2009;1216(11):2002-2032.19195661
Vellas B, Coley N, Ousset PJ, et al; GuidAge Study Group. Long-term use of standardised Ginkgo biloba extract for the prevention of Alzheimer's disease (GuidAge): a randomised placebo-controlled trial. Lancet Neurol. 2012;11(10):851-859.22959217
Von Gunten A, Schlaefke S, Überla K. Efficacy of Ginkgo biloba extract EGb 761 in dementia with behavioural and psychological symptoms: a systematic review. World J Biol Psychiatry. 2016;17(8):622-633.26223956
Wang Q, Zhao WZ, Ma CG. Protective effects of Ginkgo biloba extract on gastric mucosa. Acta Pharmacol Sin. 2000;21(12):1153-1156.11603292
Wang H, Wu X, Lezmi S, et al. Extract of Ginkgo biloba exacerbates liver metastasis in a mouse colon cancer Xenograft model. BMC Complement Altern Med. 2017;17(1):516.29197355
Weinmann S, Roll S, Schwarzbach C, Vauth C, Willich SN. Effects of Ginkgo biloba in dementia: systematic review and meta-analysis. BMC Geriatr. 2010;10:14.20236541
Wheatley D. Triple-blind, placebo-controlled trial of Ginkgo biloba in sexual dysfunction due to antidepressant drugs. Hum Psychopharmacol. 2004;19(8):545-548.15378664
Wimpissinger B, Berisha F, Garhoefer G, Polak K, Schmetterer L. Influence of Ginkgo biloba on ocular blood flow. Acta Ophthalmol Scand. 2007;85(4):445-449.17324220
Woelk H, Arnoldt KH, Kieser M, Hoerr R. Ginkgo biloba special extract EGb 761 in generalized anxiety disorder and adjustment disorder with anxious mood: a randomized, double-blind, placebo-controlled trial. J Psychiatr Res. 2007;41(6):472-480.16808927
Woelkart K, Feizlmayr E, Dittrich P, et al. Pharmacokinetics of bilobalide, ginkgolide A and B after administration of three different Ginkgo biloba L. preparations in humans. Phytother Res. 2010;24(3):445-450.20041430
Wolf HR. Does Ginkgo biloba special extract EGb 761 provide additional effects on coagulation and bleeding when added to acetylsalicylic acid 500 mg daily? Drugs R D. 2006;7(3):163-172.16752942
Wu Y, Li S, Cui W, Zu X, Du J, Wang F. Ginkgo biloba extract improves coronary blood flow in healthy elderly adults: role of endothelium-dependent vasodilation. Phytomedicine. 2008;15(3):164-169.18258419
Xu AH, Chen HS, Sun BC, et al. Therapeutic mechanism of Ginkgo biloba exocarp polysaccharides on gastric cancer. World J Gastroenterol. 2003;9(11):2424-2427.14606069
Yadav V, Bever C Jr, Bowen J, et al. Summary of evidence-based guideline: complementary and alternative medicine in multiple sclerosis: report of the guideline development subcommittee of the American Academy of Neurology. Neurology. 2014;82(12):1083-1092.24663230
Yancheva S, Ihl R, Nikolova G, Panayotov P, Schlaefke S, Hoerr R; GINDON Study Group. Ginkgo biloba extract EGb 761(R), donepezil or both combined in the treatment of Alzheimer's disease with neuropsychiatric features: a randomised, double-blind, exploratory trial. Aging Ment Health. 2009;13(2):183-190.19347685
Ye B, Aponte M, Dai Y, et al. Ginkgo biloba and ovarian cancer prevention: epidemiological and biological evidence. Cancer Lett. 2007;251(1):43-52.17194528
Zeng X, Liu M, Yang Y, Li Y, Asplund K. Ginkgo biloba for acute ischaemic stroke. Cochrane Database Syst Rev. 2005;(4):CD003691.16235335
Zhang J, Yang S, Chen F, Li H, Chen B. Ginkgetin aglycone ameliorates LPS-induced acute kidney injury by activating SIRT1 via inhibiting the NF-κB signaling pathway. Cell Biosci. 2017;7:44.28852469
Zhang S, Zhuang J, Yue G, et al. Lipidomics to investigate the pharmacologic mechanisms of ginkgo folium in the hyperuricemic rat model. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1060:407-415.28672255


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