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Grape Seed

Medically reviewed by Last updated on Dec 16, 2020.

What are other common names?

  • Vitis vinifera
  • Activin
  • Black Grape Raisins
  • Calzin
  • Concord Grapes
  • European Wine Grapes
  • Flame Grapes
  • Flame Raisins
  • Flame Seedless Grapes
  • Flamer Grapes
  • Grampe Leaf Extract
  • Grape Fruie
  • Grape Fruit
  • Grape Fruit Skin
  • Grape Juice
  • Grape Leaf
  • Grape Leaf Extract
  • Grape Seed Extract
  • Grape Seed Oil
  • Grape Seeds
  • Grape Skin
  • Grape Skin Extract
  • Grapes
  • Grapeseed
  • Muscat
  • Muskat
  • Oligomeric Proanthocyanidins
  • Oligomeric Procyanidins
  • OPC
  • OPCs
  • PCO
  • PCOs
  • Petite Sirah
  • Proanthocyanidin
  • Procyanidolic Oligomers
  • Purple Grapes
  • Raisins
  • Red Globe Grapes
  • Red Grapes
  • Red Malaga
  • Red Vine Leaf
  • Table Grapes
  • Thompson Seedless Grapes
  • Uva
  • Vine Leaf Extract
  • White Grapes
  • Wine Grapes

What is this product used for?

Grape seed is used by some people to help with circulation and decrease swelling. Some people may use it to lower blood pressure and improve heart rate. Others use it to prevent cell damage.

What are the precautions when taking this product?

  • Always check with your doctor before you use a natural product. Some products may not mix well with drugs or other natural products.

  • This product may interfere with some lab tests. Be sure to talk with your doctor about this and all drugs you are taking.

  • Be sure to tell your doctor that you take this product if you are scheduled for surgery or tests.

  • Take extra care if you are taking drugs to thin your blood. These are drugs like warfarin (Coumadin), heparin, or enoxaparin (Lovenox).

  • Take extra care if you are taking drugs to dissolve blood clots. These are drugs like alteplase (Activase), reteplase (Retevase), or streptokinase.

  • Take extra care if you are taking drugs to help with swelling or inflammation. These are drugs like nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin, ibuprofen (Advil), or naproxen (Naprosyn).

  • Take extra care and check with your doctor if you have:

    • Bleeding problems

    • Stomach bleeding or ulceration

What should I watch for?

  • Upset stomach or cramps

When do I need to call the doctor?

  • Signs of a very bad reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat. Go to the ER right away.

  • Very bad throwing up

  • Very bad belly pain

  • Very bad loose stools

  • Very bad headache

  • Blood in stool or toilet bowl

  • Throwing up blood

  • Bruising or bleeding that is not normal

  • Changes in menstrual periods like lots of bleeding, spotting, or bleeding between cycles.

Where can I learn more?

National Center for Complementary and Integrative Health

Last Reviewed Date


Consumer information use

This information is not specific medical advice and does not replace information you receive from your healthcare provider. Only your healthcare provider has the knowledge and training to provide advice that is right for you. You should not rely on this information in deciding whether or not to use, or accept your healthcare provider’s advice regarding use of, any natural products or similar treatments, therapies, or life-style choices. This information does not endorse any natural products or similar treatments, therapies, or life-style choices as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information. It does NOT include all information about natural products, possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to you. You must talk with your healthcare provider for complete information about your health and treatment options.


Copyright © 2018 Wolters Kluwer Clinical Drug Information, Inc. and its affiliates and/or licensors. All rights reserved.

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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.