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Grape Seed

Medically reviewed by Last updated on Mar 17, 2023.

What are other common names?

  • Vitis vinifera
  • Activin
  • Black Grape Raisins
  • Calzin
  • Concord Grapes
  • European Wine Grapes
  • Flame Grapes
  • Flame Raisins
  • Flame Seedless Grapes
  • Flamer Grapes
  • Grampe Leaf Extract
  • Grape Fruie
  • Grape Fruit
  • Grape Fruit Skin
  • Grape Juice
  • Grape Leaf
  • Grape Leaf Extract
  • Grape Seed Extract
  • Grape Seed Oil
  • Grape Seeds
  • Grape Skin
  • Grape Skin Extract
  • Grapes
  • Grapeseed
  • Muscat
  • Muskat
  • Oligomeric Proanthocyanidins
  • Oligomeric Procyanidins
  • OPC
  • OPCs
  • PCO
  • PCOs
  • Petite Sirah
  • Proanthocyanidin
  • Procyanidolic Oligomers
  • Purple Grapes
  • Raisins
  • Red Globe Grapes
  • Red Grapes
  • Red Malaga
  • Red Vine Leaf
  • Table Grapes
  • Thompson Seedless Grapes
  • Uva
  • Vine Leaf Extract
  • White Grapes
  • Wine Grapes

What is this product used for?

Grape seed may help lower blood pressure and improve heart rate in some people. It has also been used to prevent cell damage.

What are the precautions when taking this product?

  • Always check with your doctor before you use a natural product. Some products may not mix well with drugs or other natural products.

  • This product may interfere with some lab tests. Be sure to talk with your doctor about this and all drugs you are taking.

  • Do not take if you are allergic to grapes or grape products.

  • Be sure to tell your doctor that you take this product if you are scheduled for surgery or tests.

  • Be sure to tell your doctor if you are pregnant, plan on getting pregnant, or are breastfeeding. You will need to talk about the benefits and risks of using this natural product.

  • Take extra care if you are taking drugs to thin your blood. These are drugs like warfarin, heparin, or enoxaparin.

  • Take extra care if you are taking drugs to dissolve blood clots. These are drugs like alteplase, reteplase, or streptokinase.

  • Take extra care if you are taking drugs to help with swelling or inflammation. These are drugs like nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin, ibuprofen, or naproxen.

  • Take extra care and check with your doctor if you have:

    • Bleeding problems

    • Stomach bleeding or ulceration

What should I watch for?

  • Upset stomach or cramps

When do I need to call the doctor?

  • Signs of a very bad reaction. These include wheezing; chest tightness; trouble breathing, swallowing, or talking; fever; rash; hives; itching, discolored, swollen, blistered, or peeling skin; or swelling of face, lips, tongue, or throat. Go to the ER right away.

  • Very bad throwing up

  • Blood in stool or toilet bowl

  • Throwing up blood

  • Bruising or bleeding that is not normal

  • Changes in menstrual periods like lots of bleeding, spotting, or bleeding between cycles.

Where can I learn more?

National Center for Complementary and Integrative Health

Last Reviewed Date


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