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Tpoxx (oral/injection)

Generic name: tecovirimat (oral/injection) [ TEK-oh-VIR-i-mat ]
Brand name: Tpoxx
Drug class: Miscellaneous antivirals

Medically reviewed by Drugs.com on Oct 3, 2023. Written by Cerner Multum.

What is tecovirimat?

Tecovirimat is used to treat smallpox disease caused by the Variola virus in people who weigh at least 7 pounds (3 kg).

Tecovirimat may also be used for purposes not listed in this medication guide.

Tecovirimat side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tpoxx may cause serious side effects. Call your doctor at once if you have:

Common side effects of Tpoxx may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings

Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.

Before taking this medicine

You should not use tecovirimat injection if you have severe kidney problems.

Tell your doctor if you have ever had:

It is not known if tecovirimat will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Do not breastfeed. Talk to your doctor about the best way to feed your baby if you are using tecovirimat.

How should I use tecovirimat?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Tecovirimat oral is taken by mouth.

Tecovirimat oral doses are based on weight. Your dose may change if you gain or lose weight. Take this medicine for the full 14 day course treatment.

Take tecovirimat oral within 30 minutes after a fatty meal. Talk with your doctor about what types of foods to eat.

Take tecovirimat oral with a full glass of water.

If you cannot swallow a capsule whole, open it and mix the medicine with milk, infant formula, pudding or applesauce. Swallow the mixture right away without chewing.

Tecovirimat injection is given in a vein by a healthcare provider slowly over 6 hours using an infusion pump.

Store tecovirimat oral in the original container at room temperature away from moisture and heat.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if your next dose is due in less than 8 hours. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using tecovirimat?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect tecovirimat?

Tell your doctor about all your other medicines, especially repaglinide.

This list is not complete. Other drugs may affect repaglinide, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

brincidofovir, tecovirimat

Frequently asked questions

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.