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TPOXX Dosage

Medically reviewed by Drugs.com. Last updated on Dec 2, 2021.

Generic name: TECOVIRIMAT MONOHYDRATE 200mg
Dosage form: capsule

Dosage for Adults and Pediatric Patients Weighing at Least 40 kg

The recommended dosage of TPOXX in adults and pediatric patients weighing at least 40 kg is as shown in Table 1. The dose should be taken orally for 14 days. TPOXX should be taken within 30 minutes after a full meal containing moderate or high fat [see Clinical Pharmacology (12.3)].

Table 1: Recommended Dosage for Pediatric and Adult Patients Weighing at Least 40 kg
Body Weight Dosage Number of Capsules
40 kg to less than 120 kg 600 mg twice daily 3 Capsules twice daily
120 kg or more 600 mg three times a day 3 Capsules three times a day

Dosage for Pediatric Patients

The recommended dosage for pediatric patients is based on weight starting at 13 kg as shown in Table 2. The dose should be given orally for 14 days and should be taken within 30 minutes after a full meal containing moderate or high fat [see Clinical Pharmacology (12.3)].

Preparation for Administration to Pediatrics and Those Who Cannot Swallow Capsules

TPOXX capsules can be administered by carefully opening the capsule and mixing the entire contents in 30 mL of liquid (e.g., milk, chocolate milk) or soft food (e.g., apple sauce, yogurt). The entire mixture should be administered within 30 minutes of its preparation.

Table 2: Recommended Pediatric and Adult Dosage and Preparation Instructions
Body Weight Dosage Number of Capsules Drug-Food Preparation
13 kg to less
than 25 kg
200 mg twice
daily
Contents of 1 Capsule
twice daily
Mix 1 capsule of TPOXX with
30 mL of liquid or soft food.
Administer the whole mixture.
25 kg to less
than 40 kg
400 mg twice
daily
Contents of 2 Capsules
twice daily
Mix 2 capsules of TPOXX with
30 mL of liquid or soft food.
Administer the whole mixture.
40 kg to less
than 120 kg
600 mg twice
daily
Contents of 3 Capsules
twice daily
Mix 3 capsules of TPOXX with
30 mL of liquid or soft food.
Administer the whole mixture.
120 kg and
above
600 mg three
times daily
Contents of 3 Capsules
three times daily
Mix 3 capsules of TPOXX with 30
mL of liquid or soft food.
Administer the whole mixture.

Frequently asked questions

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