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TPOXX Dosage

Generic name: TECOVIRIMAT MONOHYDRATE 200mg
Dosage form: capsule

Medically reviewed by Drugs.com. Last updated on July 14, 2020.

Dosage for Adults and Pediatric Patients Weighing at Least 40 kg

The recommended dosage of TPOXX in adults and pediatric patients weighing at least 40 kg is 600 mg (three 200 mg capsules) taken twice daily orally for 14 days. TPOXX should be taken within 30 minutes after a full meal of moderate or high fat [see Clinical Pharmacology (12.3)].

Dosage for Pediatric Patients

The recommended dosage for pediatric patients is based on weight starting at 13 kg as shown in Table 1. The dose should be given twice daily orally for 14 days and should be taken within 30 minutes after a full meal of moderate or high fat [see Clinical Pharmacology (12.3)].

Preparation for Administration to Pediatrics and Those Who Cannot Swallow Capsules

TPOXX capsules can be administered by carefully opening the capsule and mixing the entire contents in 30 mL of liquid (e.g., milk, chocolate milk) or soft food (e.g., apple sauce, yogurt). The entire mixture should be administered within 30 minutes of its preparation.

Table 1: Recommended Pediatric and Adult Dosage and Preparation Instructions
Body Weight Dosage Number of Capsules Drug-Food Preparation
13 kg to less
than 25 kg
200 mg twice
daily
Contents of 1 Capsule
twice daily
Mix 1 capsule of TPOXX with
30 mL of liquid or soft food.
Administer the whole mixture.
25 kg to less
than 40 kg
400 mg twice
daily
Contents of 2 Capsules
twice daily
Mix 2 capsules of TPOXX with
30 mL of liquid or soft food.
Administer the whole mixture.
40 kg and
above
600 mg twice
daily
Contents of 3 Capsules
twice daily
Mix 3 capsules of TPOXX with
30 mL of liquid or soft food.
Administer the whole mixture.

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