Sulfinpyrazone (Oral)

Generic name: sulfinpyrazone [ sul-fin-PIR-a-zone ]
Drug class: Antigout agents

Medically reviewed by Drugs.com. Last updated on Dec 12, 2024.

Uses for sulfinpyrazone

Sulfinpyrazone is used in the treatment of chronic gout (gouty arthritis), which is caused by too much uric acid in the blood. The medicine works by removing the extra uric acid from the body. Sulfinpyrazone does not cure gout, but after you have been taking it for a few months it may help prevent gout attacks. This medicine will help prevent gout attacks only as long as you continue to take it.

Sulfinpyrazone is sometimes used to prevent or treat other medical problems that may occur if too much uric acid is present in the body.

Sulfinpyrazone may also be used for other conditions as determined by your doctor.

Sulfinpyrazone is available only with your doctor's prescription.

Before using sulfinpyrazone

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of sulfinpyrazone in children with use in other age groups.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of sulfinpyrazone in the elderly with use in other age groups.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Abrocitinib
Defibrotide

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Aceclofenac
Acemetacin
Alipogene Tiparvovec
Alteplase, Recombinant
Amtolmetin Guacil
Anagrelide
Apixaban
Ardeparin
Argatroban
Bemiparin
Betrixaban
Bivalirudin
Bromfenac
Bufexamac
Caplacizumab-yhdp
Celecoxib
Certoparin
Choline Salicylate
Cilostazol
Citalopram
Clonixin
Clopidogrel
Curcumin
Cyclosporine
Dabigatran Etexilate
Dalteparin
Danaparoid
Desirudin
Desvenlafaxine
Dexibuprofen
Dexketoprofen
Diclofenac
Dicumarol
Diflunisal
Dipyridamole
Dipyrone
Droxicam
Duloxetine
Edoxaban
Enoxaparin
Eptifibatide
Escitalopram
Etodolac
Etofenamate
Etoricoxib
Felbinac
Fenoprofen
Fepradinol
Feprazone
Floctafenine
Flufenamic Acid
Fluoxetine
Flurbiprofen
Fluvoxamine
Fondaparinux
Heparin
Ibrutinib
Ibuprofen
Indomethacin
Inotersen
Ketoprofen
Ketorolac
Lepirudin
Levomilnacipran
Lornoxicam
Loxoprofen
Lumiracoxib
Meclofenamate
Mefenamic Acid
Meloxicam
Melphalan
Milnacipran
Morniflumate
Nabumetone
Nadroparin
Naproxen
Nepafenac
Niflumic Acid
Nimesulide
Nimesulide Beta Cyclodextrin
Oxaprozin
Oxyphenbutazone
Parecoxib
Parnaparin
Paroxetine
Pegloticase
Phenindione
Phenprocoumon
Phenylbutazone
Piketoprofen
Piracetam
Piroxicam
Proglumetacin
Propyphenazone
Proquazone
Protein C
Reviparin
Rivaroxaban
Rofecoxib
Salicylic Acid
Salsalate
Selumetinib
Sertraline
Sodium Salicylate
Sulindac
Tenecteplase
Tenoxicam
Tiaprofenic Acid
Ticagrelor
Tinzaparin
Tolfenamic Acid
Tolmetin
Trazodone
Turmeric
Valdecoxib
Venlafaxine
Vilazodone
Vortioxetine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Anisindione
Bismuth Subsalicylate
Warfarin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Proper use of sulfinpyrazone

If sulfinpyrazone upsets your stomach, it may be taken with food. If this does not work, an antacid may be taken. If stomach upset (nausea, vomiting, or stomach pain) continues, check with your doctor.

In order for sulfinpyrazone to help you, it must be taken regularly as ordered by your doctor.

When you first begin taking sulfinpyrazone, the amount of uric acid in the kidneys is greatly increased. This may cause kidney stones in some people. To help prevent this, your doctor may want you to drink at least 10 to 12 full glasses (8 ounces each) of fluids each day, or to take another medicine to make your urine less acid. It is important that you follow your doctor's instructions very carefully.

For patients taking sulfinpyrazone for gout:

After you begin to take sulfinpyrazone, gout attacks may continue to occur for a while. However, if you take this medicine regularly as directed by your doctor, the attacks will gradually become less frequent and less painful. After you have been taking sulfinpyrazone for several months, they may stop completely.
Sulfinpyrazone helps to prevent gout attacks. It will not relieve an attack that has already started. Even if you take another medicine for gout attacks, continue to take this medicine also.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For treating gout or removing uric acid from the body:
- Adults: The starting dose of sulfinpyrazone is usually 100 mg or 200 mg a day (one-half of a 100-mg tablet two times a day, one 100-mg tablet one or two times a day, or one 200-mg capsule or tablet once a day). Then, the dose is usually increased by 100 mg or 200 mg every few days, up to 800 mg a day. Starting with a low dose and increasing the dose gradually helps prevent kidney stones and other side effects. After a while, the dose may be changed again, depending on the amount of uric acid in your blood or urine.
- Children: It is not likely that sulfinpyrazone will be needed to treat gout or remove uric acid from the body in children. However, if a child needs this medicine, the dose would have to be determined by the doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions while using sulfinpyrazone

Your doctor should check your progress at regular visits to make sure that this medicine does not cause unwanted effects.

Before you have any medical tests, tell the person in charge that you are taking this medicine. The results of some tests may be affected by sulfinpyrazone.

For patients taking sulfinpyrazone for gout or to help remove uric acid from the body:

Taking aspirin or other salicylates may lessen the effects of sulfinpyrazone. This will depend on the dose of aspirin or other salicylate that you take, and on how often you take it. Also, drinking too much alcohol may increase the amount of uric acid in the blood and lessen the effects of sulfinpyrazone. Therefore, do not take aspirin or other salicylates or drink alcoholic beverages while taking this medicine, unless you have first checked with your doctor.

Side Effects of sulfinpyrazone

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

Shortness of breath, troubled breathing, tightness in chest, and/or wheezing
sores, ulcers, or white spots on lips or in mouth
sore throat and fever with or without chills
swollen and/or painful glands
unusual bleeding or bruising

Symptoms of overdose

Clumsiness or unsteadiness
convulsions (seizures)
diarrhea
nausea or vomiting (severe or continuing)
stomach pain (severe or continuing)
difficulty in breathing

Check with your doctor as soon as possible if any of the following side effects occur:

More common

Lower back and/or side pain
painful urination (possibly with blood)

Less common

Skin rash

Rare

Bloody or black, tarry stools
fever
increased blood pressure
pinpoint red spots on skin
sudden decrease in amount of urine
swelling of face, fingers, feet, and/or lower legs
unusual tiredness or weakness
vomiting of blood or material that looks like coffee grounds
weight gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common