Skip to main content


Generic name: luspaterceptlus-PAT-er-sept ]
Drug class: Miscellaneous erythropoiesis agents

Medically reviewed by on Dec 6, 2021. Written by Cerner Multum.

What is Reblozyl?

Reblozyl is for use in adults with a blood disorder called beta thalassemia, in which the body does not produce enough hemoglobin (HEEM o glo bin). Hemoglobin carries oxygen through your blood to tissues and organs.

Reblozyl is used to treat anemia (lack of red blood cells) in adults with beta thalassemia who need to have regular red blood cell transfusions.

Reblozyl may also be used for purposes not listed in this medication guide.


Before using Reblozyl tell your doctor about all your medical conditions or allergies, all medicines you use, and if you are pregnant or breastfeeding.

Before taking this medicine

Tell your doctor if you have ever had:

Tell your doctor if you are pregnant or could become pregnant. Reblozyl may harm an unborn baby. Use effective birth control to prevent pregnancy while you are using Reblozyl and for at least 3 months after your last dose.

Do not breastfeed while using this medicine, and for at least 3 months after your last dose.

How is Reblozyl given?

Reblozyl is injected under the skin, usually once every 3 weeks.

A healthcare provider will give you this injection.

Before each injection, your will need a blood test to check your hemoglobin levels. Be sure to tell your healthcare provider when you last had a blood transfusion.

Reblozyl doses are based on weight. Your dose needs may change if you gain or lose weight.

Your blood pressure will need to be checked often.

You may be given other medications to help control your blood pressure. Keep using this medicine for as long as your doctor has prescribed.

What happens if I miss a dose?

You should receive an injection as soon as you can, and then go back to your regular schedule. At least 3 weeks should pass between each injection.

What happens if I overdose?

Since Reblozyl is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while receiving Reblozyl?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Reblozyl side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers right away if you have:

  • severe headache, blurred vision, pounding in your neck or ears;

  • signs of a stroke--sudden numbness or weakness (especially on one side of the body), severe headache, slurred speech, balance problems;

  • signs of a blood clot in the lung--chest pain, sudden cough, wheezing, rapid breathing, coughing up blood; or

  • signs of a blood clot deep in the body--swelling, warmth, or redness in an arm or leg.

Your Reblozyl injections may be delayed or permanently discontinued if you have certain side effects.

Common side effects of Reblozyl may include:

  • stomach pain, diarrhea;

  • headache, dizziness;

  • feeling tired;

  • cough; or

  • bone pain, joint pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Reblozyl?

Other drugs may affect Reblozyl, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.